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All Journal Jurnal Kedokteran Brawijaya JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Cardiology ACI (Acta Cardiologia Indonesiana) Journal of Issues in Midwifery Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Journal of Nursing Science Update Journal of Community Health and Preventive Medicine (JOCHAPM)
Cholid Tri Tjahjono
Brawijaya Cardiovascular Research Center Department Of Cardiology And Vascular Medicine Faculty Of Medicine, Universitas Brawijaya Malang
Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Indonesian Journal of Cardiology

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Sensitivitas Barorefleks pada Penderita Penyakit Jantung Koroner yang Menjalani Intervensi Koroner Perkutan Cholid Tri Tjahjono; Muhammad Munawar; RWM Kaligis; Idris Idham
Jurnal Kardiologi Indonesia Vol. 28, No. 6 November 2007
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v28i6.207

Abstract

Background.Autonomic dysfunction contributes to incidence of ventricular arrhythmias and sudden cardiac death in patients with coronary artery disease (CAD). Revascularization, for example percutaneous coronary intervention (PCI), is intended to improve myocardial perfusion. Besides that, PCI is considered to improve autonomic dysfunction. This study is aimed at assessing baroreflex sensitivity (BRS) in patients with CAD before and after PCI.Methods. Patients with angiographically having coronary stenoses = 50% who underwent coronary angioplasty at the catheterization laboratorium of National Cardiovascular Center Harapan Kita, Jakarta, were included in this study. Baroreflex sensitivity was calculated by administering nitroglycerin 300 µg intra aortic before and after PCI.Results.Subjects comprise of 8 (42%) male and 11 (58%) female, aged 57.5 ± 9.3 year old. Most of subjects had dyslipidemia (57%), were smoker (42%), had hypertension (42%) and only 3 (16%) had diabetes mellitus. Nine (47%) of subjects had previous history of myocardial infarction. Medications suspected affecting baroreflex sensitivity, which were used by the time of study included nitrate (63%), beta-blockade (58%), and calcium antagonist (32%). Mean value of baroreflex sensitivity pre-PCI and post-PCI were 2,51+3,23 ms/mmHg and 1,96+1,61 ms/mmHg (p=0,412), subsequently. Multivariate analysis with logistic regression showed that nitrate has significant effect on decreased BRS soon after PCI (p=0,023; CI 95% 1,496-216,62;OR 18,00).Conclusion. In patients with Coronary Artery Disease, immediately after percutaneous coronary intervention, barorefelex sensitivity was decreased. Nitrate has significant effect on alteration of barorefelex sensitivity.
Co-Authors Adhika Prastya Wikananda Aditya Reza Pratama Adriyawan Widya Nugraha Anjarwani, Setyasih Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Ardani Galih Ardani Galih Prakosa Ardhani Galih Ardhani Galih Ardian Rizal Ardian Rizal Arif Wicaksono Arif Wicaksono Aris Munandar ZI Ayu Asri Devi Adityawati Ayu Asri Devi Adityawati Bambang Rahardjo Budi Satrijo Budi Satrijo Budi Satrijo Dadang Hendrawan David Rubiyaktho Dedy Irawan Diah Ivana Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dwi Adi Nugroho Dyah Ayu Ikeningrum Ema Pristi Yunita Ema Pristi Yunita, Ema Pristi Evit Ruspiono Evit Ruspiono Fahmy Rusnanta Fandy Hazzi Alfata Fandy Hazzy Alfata Hendrawati Hendrawati Heny Martini Heny Martini Heny Martini Hidayanti, Puji Astuti Nur Idris Idham Imelda Krisnasari Indra Prasetya Indra Prasetya Indriani, Anin Iskandar Iskandar Liemena Harold Adrian Maimun Zulhaidah Arthamin Mifetika Lukitasari Mohammad Ryan Ramadhan Mohammad Saifur Rohman Mohammad Saifur Rohman Monika Sitio Muchammad Dzikrul Haq Karimullah Muhammad Abusari Muhammad Munawar Muhammad Rizki Fadlan Muhammad Rizki Fadlan Muhammad Rizki Rizki Fadlan Ni Putu Frida Baskarani Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Novi Kurnianingsih Novi Kurniningsih Oktafin Srywati Pamuna Olivia Handayani Pawik Supriadi Puji Astuti Nur Hidayanti Ratna Pancasari RWM Kaligis Sasmojo Widito Sasmojo Widito Sasmojo Widito sawitri satwikajati Sawitri Satwikajati Seprian Widasmara Setyasih Anjarwani Setyasih Anjarwani Teguh Aryanugraha Titin Andri Wihastuti Titin Andri Wihastuti Tonny Adriyanto Tri Astiawati Valerina Yogibuana Swastika Putri Valerina Yogibuana Swastikaputri Valerinna Yogibuana Swastika Putri Wira Kimahesa Anggoro Yoga Waranugraha Yordan Wicaksono Ashari Yusuf Arifin Zainal Fathurohim Zulhaidah A, Maimun