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All Journal Heart Science Journal Narra J Cermin Dunia Kedokteran Jurnal Klinik dan Riset Kesehatan
Fajar, Jonny Karunia
Department Of Internal Medicine, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Korelasi Derajat Graves’ Ophthalmopathy dengan Durasi Menderita Hipertiroid Fajar, Jonny Karunia; Hidayah, Cut Intan; Zaini, Lia Meuthia; Zufry, Hendra; -, Jamhur
Cermin Dunia Kedokteran Vol 42, No 5 (2015): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.188 KB) | DOI: 10.55175/cdk.v42i5.1006

Abstract

Graves’ ophthalmopathy merupakan penyakit autoimun. Studi ini bertujuan untuk mengetahui distribusi manifestasi klinis Graves’ ophthalmopathy dan mengetahui kaitan lama menderita hipertiroid dengan derajat keparahan Graves’ ophthalmopathy. Penelitian ini merupakan penelitian observasional analitik dengan 34 sampel penderita Graves’ ophthalmopathy. Data dianalisis menggunakan uji Spearman. Hasil penelitian ini menunjukkan bahwa distribusi manifestasi klinis penderita Graves’ ophthalmopathy di poliklinik endokrin RSUZA adalah 23,5% derajat 0; 8,8% derajat 1; 14,7% dengan derajat 2; 14,7% derajat 3; 11,7% derajat 4; 20,5% derajat 5; dan 5,8% derajat 6. Terdapat asosiasi signifikan antara lama menderita hipertiroid dengan derajat Graves’ ophthalmopathy (p=0,000). Kebanyakan penderita Graves’ ophthalmopathy memiliki manifestasi klinis derajat 0 dan lama menderita hipertiroid berbanding lurus dengan tingkat keparahan Graves’ ophthalmopathy.Graves’ ophthalmopathy is an autoimmune disease. The aim of this study is to determine the characteristic of the clinical manifestations of Graves’ ophthalmopathy and the association between duration of hyperthyroidism and the degree of Grave’s ophthalmopathy. It is an analytical observational study in 34 patients with Graves’ ophthalmopathy. Data were analyzed using the Spearman test. It showed that 23.5% of the patients were in stage 0; 8.8% were in stage 1; 14.7% were in stage 2; 14.7% were in stage 3; 11.7% were in stage 4; 20.5% were in stage 5; and 5.8% were in stage 6. There was a significant association between the degree of Graves’ ophthalmopathy and duration of hyperthyroidism. Majority of the patients with Graves’ ophthalmopathy had clinical manifestation of stage 0 and the duration of hyperthyroidism was significantly associated with the severity of Graves’ ophthalmopathy.
The Effect of Garcinia Mangostana Linn Extract to The Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with High Framingham Score Aditha Satria Maulana; Djanggan Sargowo; Ardian Rizal; Heny Martini; Mohammad Saifur Rohman; Anna Fuji Rahimah; Jonny Karunia Fajar
Heart Science Journal Vol 1, No 2 (2020): The Assessment of Diagnostic and Treatment Modality in Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (32.966 KB) | DOI: 10.21776/ub.hsj.2020.001.02.6

Abstract

Background : Recently, studies have concerned on the use of xanthones for treating patients with cardiovascular diseases. In our country, xanthones were found in Garcinia Mangostana Linn.Objectives : To assess the effect of Garcinia Mangostana Linn Extract (GMLE) to the levels of Circulating Endothelial Cells (CEC) and Endothelial Progenitor Cells (EPC) in patients with high framingham score.Methods : A prospective cohort study was conducted from November 2018 to January 2019. The patients were divided into two groups. The first group was given 2520 mg/day of GMLE for 90 days and the second group was given placebo. In sub group analyses, patients were divided based on previous medication, including statin, statin and angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB), statin and oral antidiabetic drugs (OAD), and statin and ACEI or ARB and OAD. The outcome measures were CEC and EPC levels, measured at baseline and after 90 days of treatment. We used multiple linear regression to analyze the correlation and effect estimates.Results: A total of 72 patients was included in our study. All of the patients baseline characteristics were distributed homogeneously (p>0.05). Our findings confirmed that GMLE administration was associated with decreased CEC level compared to placebo. On other hands, increased EPC level compared to placebo was observed after GMLE administration. In sub-group analyses, our study found that the combination of GMLE with statin and ACEI or ARB and the combination of GMLE with statin and ACEI or ARB and OAD were associated with decreased level of CEC compared to placebo, with the odd ratios were 0.12 and 0.18, respectively. Conversely, increased level of EPC was observed in subjects receiving the combination of GMLE with statin and ACEI or ARB and the combination of GMLE with statin.Conclusion: Administration of GMLE as adjuvant therapy is associated with the improvement of CEC and EPC levels in patients with high framingham scores.
Decline of notified dengue infections in Indonesia in 2017: Discussion of the possible determinants Pandji Wibawa Dhewantara; Kurnia F. Jamil; Jonny Karunia Fajar; Panji Probo Saktianggi; Roy Nusa; Triwibowo Ambar Garjito; Samsul Anwar; Firzan Firzan; Dewi Megawati; R. Tedjo Sasmono; Mudatsir Mudatsir
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.23

Abstract

This study was conducted to quantify the trend in dengue notifications in the country in 2017 and to explore the possible determinants. Annual nation-wide dengue notification data were obtained from the National Disease Surveillance of Ministry of Health of Indonesia. Annual incidence rate (IR) and case fatality rate (CFR) in 2017 and the previous years were quantified and compared. Correlations between annual larva free index (LFI), implementation coverage of integrated vector management (IVM), El Niño Southern Oscillation (Niño3.4), Dipole Mode Index (DMI), Zika virus seropositivity and the percent change in IR and CFR of dengue were examined. The change of dengue IR and CFRs were mapped. In 2017, dengue IR was declined by 71% (22.55 per 100,000 population) compared to 2016 (77.96 per 100,000 population) while the CFR was slightly reduced from 0.79% to 0.75%. Reduction in IR and CFR occurred in 94.1% and 70.1% out of 34 provinces, respectively. The trend of dengue IR seems to be influenced by Niño3.4 but there is no clear evidence that Niño3.4 is the main reason for dengue reduction in 2017. It is difficult to elucidate that the reduction of dengue in 2017 was associated with previous Zika outbreaks. In conclusion, there was a significant reduction on dengue notifications in Indonesia in 2017. Further investigation is needed to look at the role of climate on the decline of dengue IR at finer temporal scale. In addition, study on the role of cross-protective immunity generated by Zika infection on dengue incidence is also warranted.
Korelasi Derajat Graves’ Ophthalmopathy dengan Durasi Menderita Hipertiroid Jonny Karunia Fajar; Cut Intan Hidayah; Lia Meuthia Zaini; Hendra Zufry; Jamhur -
Cermin Dunia Kedokteran Vol 42, No 5 (2015): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i5.1006

Abstract

Graves’ ophthalmopathy merupakan penyakit autoimun. Studi ini bertujuan untuk mengetahui distribusi manifestasi klinis Graves’ ophthalmopathy dan mengetahui kaitan lama menderita hipertiroid dengan derajat keparahan Graves’ ophthalmopathy. Penelitian ini merupakan penelitian observasional analitik dengan 34 sampel penderita Graves’ ophthalmopathy. Data dianalisis menggunakan uji Spearman. Hasil penelitian ini menunjukkan bahwa distribusi manifestasi klinis penderita Graves’ ophthalmopathy di poliklinik endokrin RSUZA adalah 23,5% derajat 0; 8,8% derajat 1; 14,7% dengan derajat 2; 14,7% derajat 3; 11,7% derajat 4; 20,5% derajat 5; dan 5,8% derajat 6. Terdapat asosiasi signifikan antara lama menderita hipertiroid dengan derajat Graves’ ophthalmopathy (p=0,000). Kebanyakan penderita Graves’ ophthalmopathy memiliki manifestasi klinis derajat 0 dan lama menderita hipertiroid berbanding lurus dengan tingkat keparahan Graves’ ophthalmopathy.Graves’ ophthalmopathy is an autoimmune disease. The aim of this study is to determine the characteristic of the clinical manifestations of Graves’ ophthalmopathy and the association between duration of hyperthyroidism and the degree of Grave’s ophthalmopathy. It is an analytical observational study in 34 patients with Graves’ ophthalmopathy. Data were analyzed using the Spearman test. It showed that 23.5% of the patients were in stage 0; 8.8% were in stage 1; 14.7% were in stage 2; 14.7% were in stage 3; 11.7% were in stage 4; 20.5% were in stage 5; and 5.8% were in stage 6. There was a significant association between the degree of Graves’ ophthalmopathy and duration of hyperthyroidism. Majority of the patients with Graves’ ophthalmopathy had clinical manifestation of stage 0 and the duration of hyperthyroidism was significantly associated with the severity of Graves’ ophthalmopathy.
Prevalensi Burnout Pada Tenaga Kesehatan di RSUD Dr. Saiful Anwar Selama Pandemi Covid-19: Sebuah Studi Potong-Lintang Besut Daryanto; Frilya Rachma Putri; Jemmy Kurniawan; Muhammad Ilmawan; Jonny Karunia Fajar
Jurnal Klinik dan Riset Kesehatan Vol 2 No 1 (2022): Oktober
Publisher : RSUD Dr. Saiful Anwar Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.1.2

Abstract

Pendahuluan: Sebagai garda terdepan dalam penanganan COVID-19, tenaga kesehatan merupakan salah satu pihak yang paling terdampak oleh pandemi COVID-19. Menghadapi berbagai macam tantangan, seperti risiko tertular dan menularkan virus, tenaga kesehatan memiliki risiko lebih besar untuk mengalami burnout. Tujuan: Penelitian ini bertujuan untuk melihat prevalensi burnout beserta faktor yang berasosiasi terhadap burnout pada tenaga kesehatan di Rumah Sakit Umum Daerah Dr. Saiful Anwar (RSSA) selama pandemi COVID-19. Metode: Penelitian ini menggunakan desain studi potong-lintang dengan menggunakan kuesioner yang disebarkan secara daring kepada seluruh tenaga kesehatan di RSSA. Penilaian burnout menggunakan Maslach Burnout Inventory-Human Services Survey (MBI-HSS). Asosiasi dianalisis menggunakan regresi logistik dan disajikan dalam odds ratio (OR) dengan confidence interval 95% (CI 95%). Hasil: Sebanyak 444 tenaga kesehatan di RSSA ikut serta dalam penelitian ini. Sebanyak 21,6% dari seluruh partisipan mengalami burnout. Partisipan dengan usia >40 tahun memiliki risiko 3,7 kali lebih rendah mengalami burnout dibandingkan dengan yang berusia <30 tahun. Sedangkan partisipan yang bekerja 70-100 dan >100 jam per minggu, masing-masing memiliki risiko 2,4 dan 4,5 kali lipat lebih tinggi dibandingkan dengan yang bekerja <70 jam per minggu. Kesimpulan: Hampir seperlima tenaga kesehatan di RSSA mengalami burnout selama pandemi COVID-19, terutama mereka yang berusia <30 tahun dan bekerja >70 jam per minggu.
Co-Authors -, Jamhur Aditha Satria Maulana Anna Fuji Rahimah Ardian Rizal Cut Intan Hidayah Dewi Megawati Djanggan Sargowo Firzan Firzan Frilya Rachma Putri Hendra Zufry Hendra Zufry, Hendra Heny Martini Hidayah, Cut Intan Jamhur - Jemmy Kurniawan Kurnia F. Jamil Lia Meuthia Zaini, Lia Meuthia Mohammad Saifur Rohman Mudatsir Mudatsir Muhammad Ilmawan Pandji Wibawa Dhewantara Panji Probo Saktianggi R. Tedjo Sasmono Roy Nusa Samsul Anwar Triwibowo Ambar Garjito