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Le Mai Huong
Institute of Natural Products Chemistry, VAST
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Mathematics

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THE SYNTHESIS OF A NOVEL BIBENZOPYRAN RELIED ON ELECTROOXYDATION OF MALLOAPELTA B BY CYCLIC VOLTAMMETRY Phan Thi Binh; Bui Hai Ninh; Chau Van Minh; Nguyen Hoai Nam; Le Mai Huong; Phan Van Kiem
ASEAN Journal on Science and Technology for Development Vol. 24 No. 4 (2007): ASEAN Journal on Science and Technology for Development (AJSTD)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (190.997 KB) | DOI: 10.29037/ajstd.210

Abstract

A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50: 0.46 µg/m) and rhabdosarcoma (RD; IC50: 0.33 µg/m). These results were the same that of  malloapelta B  (Hep-2, IC50: 0.49 µg/ml and  KB, IC50: 0.54 µg/ml). 
Co-Authors Bui Hai Ninh Chau Van Minh Nguyen Hoai Nam Phan Thi Binh Phan Van Kiem