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All Journal JURNAL PHOTON Jurnal Inovasi Pendidikan dan Sains Unri Conference Series: Community Engagement
Riryn Novianty
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Nursing Physics

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Journal : JURNAL PHOTON

 1 
Analisis Interaksi Senyawa Guvakolin dan Homoarekolin terhadap MAO-A secara in Silico Riryn Novianty
Sistem Informasi Vol 13 No 1 (2022): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i1.5042

Abstract

This study was aimed to conduct the inhibitory activity of the MAO-A enzyme (PDB ID: 2Z5Y) by the active compounds of Areca catechu L. The method used is in silico approach using AutoDock Vina, PyMol, and Discovery Studio (DSV). The prediction of pharmacokinetic properties and drug-likeness used the Swiss-ADME online website. The docking results exhibited guvacoline has a binding free energy value of -5.9 kcal / mol compared to homoarecoline (-5.4 kcal / mol), and positive control (-5.7 kcal / mol). Guvacoline compounds have a hydrogen bond in the active site of the enzyme. Areca nut compounds obtained good results on pharmacokinetic properties, but not so good on the BBB parameter. The compounds obtained good results for the parameters of the Lipinski, Veber rule, bioavailability score, but the guvacoline compounds could not meet Ghose's rule. The results of the bioavailability radar showed that the compounds have properties as oral drug.
Biodegradasi Hidrokarbon Crude Oil di Kawasan PT. Bumi Siak Pusako-Pertamina Hulu menggunakan Konsorsium Bakteri Indigen Riryn Novianty; Yuharmen Yuharmen
Sistem Informasi Vol 13 No 2 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i2.5053

Abstract

Riau Province is one of the largest producing areas of crude oil. Drilling and refining petroleum often produce waste crude oil in large quantities. One method that can be used to degrade waste is biodegradation using a consortium of microorganisms. This study examined the effectiveness of a consortium of indigenous bacteria in degrading hydrocarbon compounds. Growth tests and the ability of isolates to degrade hydrocarbons were carried out by inoculating isolates in liquid Bushnell Haas media containing crude oil of about 5% and incubating for 16 days. The potency of the indigen bacterial consortium during the degradation process is influenced by several parameters, including pH, OD (Optical Density), dan CO2 observed on days 0, 4, 8, 12 and 16 days of incubation. KB4 is the superior consortium in degrading hydrocarbon crude oil. Based on the analysis using GC-MS instruments, the bacteria consortium can degrade two hydrocarbon compounds in crude oil.
Co-Authors Aisyah Fitrida Amir Awaluddin Evelin Natasyah Naila Rahmi Nova Wahyu Pratiwi Prima Fitra Rizki Dwi Ningsih Saryono Sony Ananta Yuharmen Yuharmen