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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL ILMU KEFARMASIAN INDONESIA
HANIFA MARISA
UNIVERSITAS SRIWIJAYA
Medicine & Pharmacology

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Activity Tests of Bioactive Material of Salung Leaf (Psychotria viridiflora Reinw. Ex. Blume) against Salmonella thypi Bacteria In Vitro And In Vivo SALNI SALNI; HANIFA MARISA; HARMIDA HARMIDA
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417.075 KB)

Abstract

Activity test of bioactive material of Salung leaf (Psychotria viridiflora Reinw. ex. Blume) against Salmonella thypi in vitro and in vivo has been carried out. Bioactive material was obtained from the maceration and followed by fractionation of liquid-liquid fractionation. Antibacterial activity test performed in vitro to determine the value of the minimum inhibitory concentration (MIC) and in vivo to determine the ability of bioactive cure diarrhea in in rats (Rattus norvegicus) infected by Salmonella typhi. Treatment of bioactive material given is 0, 10, 50 and 100 mg kg-1 of weight. The results showed that the MIC of salung leaf’s bioactive material to Salmonella typhi was 250 μg mL-1. Bioactive ingredient at dose of 10 and 50 mg kg-1 were able to decrease the number of bacterial colonies to 4.14x106 cfu g-1 and 5.4x105 cfu g-1, less than 5.04x106 cfu g-1 as control. Bioactive material in weight of 100 mg kg-1 of weight could reduce the population of Salmonella typhi to zero after 12 days of treatment. The ability to reduce the amount of bacterial colonies of the bioactive material 100 mg kg-1 of weight is equal to the ability of positive control chloramphenicol 10 mg kg-1 of weight.
Antioxidant compounds and activity from the leaf of the mistletoe (Dendrophthoe pentandra (L.) Miq.) on Duku plant (Lansium domesticum Corr.) Salni Salni; Hanifa Marisa; Putri Mayasari
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.429 KB) | DOI: 10.12928/pharmaciana.v13i1.24584

Abstract

Mistletoes or benalu in Indonesia is a parasitic plant that can live on a variety of hosts. In this study determined the antioxidant activity of mistletoes living on Duku (Lansium domesticum Corr.) was Dendrophthoe pentandra (L.) Miq.  The aim of the study determine antioxidant activity used n-hexane, ethyl acetate, and methanol water fractions, and determine the compound groups and the IC50 values. The research methods used were extraction by maceration, fractionation by liquid fractionation method, isolation by vacuum liquid chromatography (VLC) and column chromatography, and antioxidant activity test with DPPH. The results showed that the n-hexane and ethyl acetate fractions which had antioxidant activity and the methanol fraction were inactive. From the n-hexane fraction, the isolates NH.1 and NH.3 were obtained, the former of which belongs to terpenoids, while the latter belongs to flavonoids. From the ethyl acetate fraction, the isolate EA.3, which also belongs to flavonoids, was obtained. The isolate NH.1 has an IC50 value of 151.35 g/mL with weak antioxidant activity, while the isolate NH.3 has 96.64 g/mL, and EA.3 has 78.37 g/mL with moderate antioxidant activity.
Co-Authors HARMIDA HARMIDA Putri Mayasari Salni Salni