AbstractScabies is a skin disease commonly found in overcrowded and poor hygiene environment. The purpose of this study was to determine the level of knowledge of students in pesantren X, East Jakarta, before and after conducting health education on scabies. The study design was a pre-post study and the data were taken on March 8, 2014. All students who came during the data collectionare the research subjects. Data was collected through a questionnaire consisting of 25 questions about the etiology, clinical symptoms, treatment, transmission, and prevention of scabies. The data were processed with SPSS version 20 and was tested with marginal homogeneity. The results showed that of 104 respondents, prior to health education, most students have a poor level of knowledge on the topic of etiology (68.3%), clinical symptoms (64.2%), treatment (51.9%), prevention (39,4%), and transmission (27.9%). After a health eduvation lecture, more than 50% of students showed a good level of knowledge on every topic on scabies (ranging from 65.4% and the highest 82.7%) while the students with poor level of knowledge on every topic ranged from 4.8%9.6%. Marginal homogeneity test showed significant differences in knowledge before and after health education (p<0.01). In conclusion, health education is effective in increasing knowledge about scabies.Keywords: scabies, knowledge, pesantren students, health education AbstrakSkabies adalah penyakit kulit yang banyak terdapat di lingkungan padat penduduk dan kebersihan yang buruk.Tujuan penelitian ini untuk mengetahui tingkat pengetahuan siswa pesantren X, Jakarta Timur, sebelum dan sesudah penyuluhan skabies. Desain penelitian adalah pre-post study dan data diambil pada 8 Maret 2014. Semua siswa yang datang saat pengumpulan data dijadikan subyek penelitian. Data dikumpulkan dengan kuesioner berisi 25 pertanyaantentang etiologi, gejala klinis, pengobatan, penularan, dan pencegahan skabies. Data diolah dengan SPSS versi 20 dan diuji dengan marginal homogeneity. Dari 104 responden, sebelum penyuluhan, sebagian besar siswa memiliki tingkat pengetahuan yang buruk tentang topik etiologi (68,3%), manifestasi klinis (64,2%), pengobatan (51,9%), pencegahan (39,4%), dan penularan(27,9%). Setelah penyuluhan, lebih dari 50% siswa memiliki pengetahuan yang baik pada setiap topik skabies (paling rendah 65,4% dan paling tinggi 82,7%) dan tingkat pengetahuan buruk pada setiap topik scabies 4,8%-9,6%. Uji marginal homogeneity menunjukkan perbedaan bermakna pada pengetahuan sebelum dan sesudah penyuluhan (p<0,01). Disimpulkan penyuluhan efektifmeningkatkan pengetahuan tentang skabies. Kata kunci: scabies, pengetahuan, siswapesantren, penyuluhan