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CHARACTERISTIC OF ORAL MEDICINE PATIENT USING TELEDENTISTRY DURING COVID-19 PANDEMIC Rahmi Amtha; Indrayadi Gunardi; Tri Erri Astoeti; M. Orliando Roeslan
ODONTO : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.8.1.18-27

Background: The COVID-19 pandemic has affected health care systems around the world. Dentistry is one of the most closely related to the production of aerosols or droplets. Minimal visits to a dental clinic or hospital are highly recommended except in emergency cases. The government's recommendation is the use of teledentistry to conduct diagnosis, treatment, and monitoring of diseases. The oral medicine field is fully in charge of this activity and until now it has never been studied how the characteristics of oral medicine patients who use teledentistry services including their level of satisfaction. Method: To describe the characteristic including the level of satisfaction of Oral Medicine patients using teledentistry in Dental Hospital Usakti during pandemic COVID-19. An observational cross-sectional study was conducted in the Oral Medicine Clinic in 31 patients who used teledentistry services at the beginning of the COVID-19 pandemic under informed consent. Validated modified questionnaire and sociodemographic data were collected and satisfaction scores were categorized. Results: The validity of the questionnaire showed Cronbach-alpha 0.83 with a reliability of 0.95 and a separation of 4.49. Most of the subject used teledentistry was female (54.83%), 31-60 years old (51.61%), no history of contact with COVID-19 patient, and prior history of teledentistry (100%, 77.41%, respectively). 93.6% of subjects showed a high satisfaction level in using teledentistry services. Conclusion: The characteristic of oral medicine patients using teledentistry described a high satisfaction level, thus the teledentistry method could be a solution in/after the pandemic era.

Ethanol extract of Imperata Cylindrica leaves inhibits proliferation and migration of HSC-3 cell lines Moehamad Orliando Roeslan; Gabriella Tasha
Dental Journal (Majalah Kedokteran Gigi) Vol. 54 No. 3 (2021): September 2021
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v54.i3.p150-154

Background: Squamous cell carcinoma (SCC) is classified as the most common type of oral cancer up to 90% of all malignant neoplasm in the oral cavity. Currently, the only treatments for SCC are surgery and/or radiation or chemotherapy, which can cause various side effects. Cogon grass leaves (Imperata cylindrica) have been considered an alternative cancer treatment that may reduce side effects. Imperata cylindrica (I. cylindrica) leaf extract can inhibit cancer cell proliferation and migration by withholding the cell cycle in the gap 1/synthesis (G1/S) and gap 2/mitosis (G2/M) phases. Therefore, the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) is decreased and cancer is not progressing. Purpose: The study aims to determine the effect of I. cylindrica leaf extract on the proliferation and migration of human oral squamous carcinoma-3 (HSC-3) cell lines. Methods: This in vitro experimental study was conducted with nine study groups. The treatment group was divided into seven concentrations—640 ppm, 320 ppm, 160 ppm, 80 ppm, 40 ppm, 20 ppm and 10 ppm. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium-bromide (MTT) assay and scratch assay were carried out to assess the effect of I. cylindrica leaf extract on HSC-3 cell proliferation and migration. Results: Ethanol extract of I. cylindrica has a significant effect compared to the negative control towards the proliferation and migration of HSC-3 cells. Conclusion: This study shows that I. cylindrica ethanol leaf extract can inhibit proliferation and migration of HSC-3 cells.

Pelatihan Deteksi Dini Kanker Mulut dengan SAMURI pada Komunitas Penyintas Kanker Love and Healthy Tangerang Rahmi Amtha; Komariah Komariah; Dewi Priandini; Muhammad Orliando Roeslan; Firstine Kelsi; Rahma Landy; Dewi Agustini; IG Sanditya Ardiana; Ilona Krista J; Stephanie Ayu Budi K
ABDI MOESTOPO: Jurnal Pengabdian Pada Masyarakat Vol 5, No 1 (2022): Januari 2022
Publisher : Universitas Prof. Dr. Moestopo (Beragama)

Kanker mulut merupakan salah satu keganasan dengan morbiditas yang tinggi dan tingkat kelangsungan hidup yang buruk. Jumlahnya masih meningkat di semua negara termasuk Indonesia. Kanker mulut merupakan keganasan yang dapat dicegah dengan melihat gejala klinis yang dikenal sebagai pra-kanker. Deteksi dini adalah salah satu solusinya. Pengabdian masyarakat ini dilakukan secara daring dilakukan pada komunitas penyintas kanker Love and Healthy Tangerang untuk meningkatkan pengetahuan tentang kanker mulut. Informasi tentang pengenalan gejala klinis dini kanker mulut, faktor risiko, pemeriksa mulut sendiri (SAMURI), dan cara menjaga kesehatan rongga mulut diberikan kepada 50 peserta selama 3 jam. Semua peserta adalah perempuan dengan rentang usia 32-64 tahun. Pelatihan dievaluasi dengan melakukan pre-test dan post-test. Terdapat peningkatan nilai rata-rata pre-test 66,38 + 1,73 dan post-test 80,43 + 1,77, dan terdapat perbedaan yang signifikan pada tingkat pengetahuan pada responden sebelum dan sesudah pelatihan (p=0,000). Antusiasme peserta sangat baik, terlihat dari 70 pertanyaan yang diajukan selama pelatihan. Dengan diadakannya pelatihan deteksi dini kanker mulut dengan SAMURI, diharapkan informasi tersebut dapat bermanfaat sehingga angka kejadian kanker mulut dapat ditekan.

Efficacy of World Health Organization-Recommended Homemade Hand Sanitizer Against Bacteria and Fungus Moehamad Orliando Roeslan; Mario Richi; Aradhea Monica Drestia; Armelia Sari Widyarman
Journal of Indonesian Dental Association Vol 4 No 2 (2021): Oktober
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v4i2.712

Introduction: Handwashing is among the best practices to prevent the transmission of various diseases especially during the pandemic. Handwashing with soap can reduce respiratory tract infections. The World Health Organization (WHO) released guidelines for making homemade hand sanitizer. Objective: This study aimed to analyze the effectiveness of antibacterial hand- rub, as recommended by WHO, containing ethanol, hydrogen peroxide, and glycerol in varying concentrations against bacteria and fungus. Methods: This experimental laboratory study was designed to assay the efficacy of hand sanitizer ingredients—96% ethanol, 3% hydrogen peroxide, and 98% glycerol, as recommended by WHO—against Escherichia coli, Staphylococcus aureus, and Candida albicans. Commercial hand rubs were used in this study for comparison. Result: Minimum inhibitory concentration (MIC) testing showed that the WHO hand rub at 25% concentration inhibited E. coli and S. aureus growth, while 12,5% concentration inhibited C. albicans. Conclusion: The WHO-recommended homemade hand sanitizer containing ethanol, hydrogen peroxide, and glycerol at a concentration of 50% is effective in eliminating Escherichia coli, Staphylococcus aureus, and concentration of 25% is effective on Candida albicans. Further study is needed to analyse these materials against other bacteria and viruses.

Effect of Ethanol Extracts from Persea americana Leaves on HSC-3 Proliferation Svetlana Tessalonica; Moehamad Orliando Roeslan
Journal of Indonesian Dental Association Vol 3 No 2 (2020): October
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v3i2.464

Introduction: Oral cancer has one of the highest death rates of all cancer types due to lack of treatment. Persea americana leaves consist of phenolic compounds that are known to have anticancer effects to inhibit the proliferation of human squamous carcinoma (HSC-3) cell lines. Ethanol extracts from P. americana leaves can inhibit the cell cycle in the G1/S and G2/M phases to give the cells time to repair damaged DNA. Objective: The aim of this study was to investigate the effect of ethanol extracts from P. americana leaves on HSC-3 proliferation. Methods: This study was conducted using experimental research and in vitro laboratory testing. Groups of extract consisted of four concentrations (100%, 50%, 25%, and 10%). Cytotoxic activity of the extracts was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium (MTT) assay. Result: P. americana leave ethanol extracts with concentrations of 100% had a significant difference (p <0.05) compared to negative control. Conclusion: Ethanol extracts from P. americana leaves could inhibit HSC-3 proliferation.

Effects of Clinacanthus nutans and Aloe vera Extracts on bFGF Synthesis in Fibroblasts Rezky Anggraeni; Moehamad Orliando Roeslan
Journal of Indonesian Dental Association Vol 5 No 1 (2022): May
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v5i1.726

Introduction: Wound healing is an important but complicated process, containing a multifaceted process. The growth factor involved in the wound healing process is basic fibroblast growth factor (bFGF). Clinacanthus nutans (C. nutans) and A. vera are traditional plants that have the ability to induce fibroblast migration. However, no study has yet compared the effects of C. nutans and A. vera on bFGF protein synthesis associated with wound healing. Objective: The aim of this study was to evaluate the effect of extracts of C. nutans and A. vera on the fibroblast synthesis of bFGF in fibroblasts. Method: Clinacanthus nutans leaf powder was extracted using a solution of hexane and chloroform sequentially. While the A. vera gel is taken. Fibroblasts were treated with several concentrations (10, 50, and 100 µg/mL) within 24 hours. Synthesis of bFGF protein was tested using enzyme linked immunoabsorbent assay (ELISA). Result: The chloroform extract of C. nutans and A. vera up regulated the synthesis of bFGF. Concentration of 10 µg/mL C. nutans showed the highest bFGF protein synthesis compared to other treatment groups. Conclusion: Chloroform extract of C. nutans and A. vera can up regulated the synthesis of bFGF in fibroblasts. ABSTRAK Pendahuluan: Penyembuhan luka adalah proses penting namun rumit, yang terdiri dari beberapa fase penyembuhan. Faktor pertumbuhan yang berhubungan dengan proses penyembuhan luka adalah, basic fibroblast growth factor (bFGF). Clinacanthus nutans (C. nutans) dan Aloe vera (A. vera) adalah tumbuhan tradisional yang memiliki kemampuan untuk menginduksi migrasi fibroblas. Namun, belum ada penelitian yang telah membandingkan efek C. nutans dan A. vera terhadap sintesis protein bFGF yang berhubungan dengan luka penyembuhan. Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui efek ekstrak C. nutans dan A. vera terhadap sintesis bFGF pada fibroblas. Metode: Bubuk daun C. nutans di ektraksi menggunakan larutan heksana dan kloroform secara berurutan. Sedangkan A. vera diambil gel nya. Fibroblas diberi perlakuan dengan beberapa konsentrasi (10, 50, dan 100 µg/mL) dalam waktu 24 jam. Sintesis protein bFGF diuji menggunakan enzym linked immunoabsorbent assay (ELISA). Hasil: Ekstrak kloroform C. nutans dan A. vera dapat meningkatkan sintesis protein bFGF lebih tinggi dibandingkan dengan kontrol negatif pada uji ELISA. C. nutans konsentrasi 10 µg/mL menunjukkan sintesis protein bFGF tertinggi dibandingkan dengan kelompok perlakuan lain. Kesimpulan: Ekstrak kloroform C. nutans dan A. vera dapat meningkatkan sintesis protein bFGF pada fibroblas.

CHARACTERISTIC OF ORAL MEDICINE PATIENT USING TELEDENTISTRY DURING COVID-19 PANDEMIC Rahmi Amtha; Indrayadi Gunardi; Tri Erri Astoeti; M. Orliando Roeslan
Odonto : Dental Journal Vol 8, No 1 (2021): July 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: The COVID-19 pandemic has affected health care systems around the world. Dentistry is one of the most closely related to the production of aerosols or droplets. Minimal visits to a dental clinic or hospital are highly recommended except in emergency cases. The government's recommendation is the use of teledentistry to conduct diagnosis, treatment, and monitoring of diseases. The oral medicine field is fully in charge of this activity and until now it has never been studied how the characteristics of oral medicine patients who use teledentistry services including their level of satisfaction. Method: To describe the characteristic including the level of satisfaction of Oral Medicine patients using teledentistry in Dental Hospital Usakti during pandemic COVID-19. An observational cross-sectional study was conducted in the Oral Medicine Clinic in 31 patients who used teledentistry services at the beginning of the COVID-19 pandemic under informed consent. Validated modified questionnaire and sociodemographic data were collected and satisfaction scores were categorized. Results: The validity of the questionnaire showed Cronbach-alpha 0.83 with a reliability of 0.95 and a separation of 4.49. Most of the subject used teledentistry was female (54.83%), 31-60 years old (51.61%), no history of contact with COVID-19 patient, and prior history of teledentistry (100%, 77.41%, respectively). 93.6% of subjects showed a high satisfaction level in using teledentistry services. Conclusion: The characteristic of oral medicine patients using teledentistry described a high satisfaction level, thus the teledentistry method could be a solution in/after the pandemic era.

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