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All Journal As-syifaa Jurnal Farmasi
Triani Putri Ayu
Fakultas Farmasi Universitas Muslim Indonesia, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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EFEK HEPATOPROTEKTOR EKSTRAK ETANOL RIMPANG DRINGO (Acorus calamus L.) TERHADAP PENINGKATAN KADAR SGPT TIKUS PUTIH (Rattus norvegicus) Hendra Herman; Sitti Amirah; Triani Putri Ayu
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (534.585 KB) | DOI: 10.33096/jifa.v10i1.335

Abstract

Hepatoprotector is a liver protected-agent of hepatotoxic. This research was aimed to determine the hepatoprotector effect of ethanol extract of dringo rhizome (Acorus calamus L.) and most effective dose as a hepatoprotector. The study using 20 male rats divided into 5 groups. Group I was given the Na-CMC 1%, group II was given a herbal supplement, and group III, IV, and V were given ethanol extract of the rhizome dringo (Acorus calamus L.) with a dose of 50 mg/100 mg, kgBB/kgBB, and 200 mg/kgBB orally for 7 days. At 5th day interval 2 hours after administering the test preparations were given a single dose of 2 g of paracetamol/kgBB in all groups except the Group I. Measurement of levels of SGPT is done before and after the treatment the animal test. From the results of a statistical analysis of Kruskal-Wallis’ test followed by Man-Whitney’s test that dringo Rhizome (Acorus calamus L.) ethanol extracts  has the effect of a hepatoprotector in rats. Extract 50 mg/kgBB dose has the same effect as statistically with herbal supplements’ group (˃ p 0.05).
Co-Authors Hendra Herman Sitti Amirah