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All Journal Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ophthalmologica Indonesiana
Resti Mulya Sari
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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Factors Which Influenced on Two Years Recurrence of Epithelial Ovarian Cancer Patients After Surgery and Platinum Based Chemotherapy SARI, RESTI MULYA
Indonesian Journal of Cancer Vol 8, No 4 (2014): Oct - Dec 2014
Publisher : "Dharmais" Cancer Center Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (657.214 KB)

Abstract

Ovarian cancer was the leading cause of death in gynecologic cancer which had the two years recurrence rate of 50%. We used retrospective cohort design with survival analysis technique to examine the role of post-surgery residual tumor size, cancer cell histological subtype and cancer cell grading on epithelial ovarian cancer recurrence. We also want to know the prevalence of HER-2 (Human Epidermal Receptor-2) overexpression in epithelial ovarian cancer patients. Sixty-five epithelial ovarian cancer patient (1998-2012) who had achieved remission were observed for 24 months. We reported median age of 50 years with recurrence rate of 36.9% and mean time of first recurrence was 19.15 months. Size of post-surgery residual tumor more than 1 cm increase Hazard Ratio (HR) of two years recurrence of epithelial ovarian cancer with p value 0.02 and HR of 3.31 (95% CI 1.46-7.49) but papillary serous histology subtype and poor differentiated cancer cell grading did not influence the recurrence. One of 38 patients showed cytoplasmic staining in HER-2 overexpression examination by immunohistochemistry methods. Conclusion: Size of post-surgery residual tumor more than 1 cm increase Hazard Ratio of two years recurrence of epithelial ovarian cancer while papillary serous histology subtype and poor differentiated cancer cell grading did not influence the recurrence. One sample showed cytoplasmic staining on HER-2 overexpression examination.
Nosocomial Clostridium difficile Diarrhea in Patient with Malignancy Andree Kurniawan; Ari Fahrial Syam; Nata Pratama; Resti Mulya Sari; Khie Chen
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (948.419 KB) | DOI: 10.24871/1222011127-132

Abstract

Clostridium difficile (C. difficile) is the main pathogen causing antibiotics associated diarrhea and colitis. This bacterium increases with hospitalization with incidence of 20-60 cases per 100,000 patients/day. C. difficile is gram positive bacilli which produce toxins in 2,700 cases in every 100,000 exposures to particular antibiotics, such as clindamycin, cephalosporin, and ampicillin. These antibiotics disrupt the intestinal normal flora and predispose to colonization of C. difficile. This case described a 53-year old male patient with squamous cell carcinoma in his left ear who came to Department of Internal Medicine, Cipto Mangunkusumo Hospital, with the complain of diarrhea since two weeks after one month hospitalization in Department of Ear, Nose, and Throat. The characteristics of the diarrhea were 10 times per day ± 100 mL, watery consistency, green yellowish in color, and no blood in the feces. Additionally, the patient also complained of pain in all parts of his stomach, especially in the epigastric area. Earlier, patient was given ceftazidime for 30 days of hospitalization. The serology examination of C. difficile in the feces showed positive result (titer = 0.790 and control = 0.190). During the colonoscopy examination, pancolitis was found and the pathologic anatomy result was found appropriate for infective colitis. Thereafter, antibiotic administration was ceased and metronidazole was administered intravenously three times a day. The diarrhea stopped after seven days and the patient was discharged. Keywords: Clostridium difficile, nosocomial diarrhea, malignancy
Uncommon bilateral orbital lesion in leukemic patient: is it cutis leukemia, celullitis or both? Poster Presentation - Case Report - Ophthalmologist ANINDITA WICITRA; Widiarti S. Soemarno; Lady P. Sukmawidowati; Agassi Suseno Sutardjo; Resti Mulya Sari; Primasari Deaningtyas; Grace Shalmont
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/s4xh6w74

Abstract

Introduction : Acute Myeloblastic Leukemia can infiltrate any parts of the body including the orbit and periocular area. This article was aimed to report uncommon sign of cutis leukemia representing as orbital cellulitis. Case Illustration : Male, 35 yo with chief complained progressive lesion in his bilateral upper and lower eyelid since 4 days before admission. He felt pain and stingy sensation around lesion. There was history of toothache. He was diagnosed with acute myeloblastic leukemia since 2 month before. Ophthalmology examination showed his visual acuity was 6/6 in both eyes with good ocular motility.His bilateral upper and lower eyelid were edematous and spasm with multiple vesicles, papule and pustule. Conjunctival injection was found in both eyes. The reminder of ophthalmology examination was unremarkable. There were other hyperemic nodules in left mandibulae and right mastoid bone. Laboratory examination showed increased leukocyte, procalcitonin and C-Reactive Protein level. Orbital CT scan revealed edema in cutis and subcutis area in both superior and inferior bilateral palpebra. Board spectrum and anaerobe antibiotic along with steroid were administered intravenously. Biopsy was performed. After two weeks medication, lesion around both palpebra was decreased. Unfortunately, because of his poor systemic condition, he was readministered to our hospital and hospitalized in ICU. He was passed away after 8 days of hospitalization. Discussion : Male patient is more likely to develop orbital infiltration of leukemia, and it necessitates significant morbidity and mortality condition. Conclusion : Leukemia with orbital invasion should bring more awareness from both ophthalmologist and hematooncologist as it indicates more mortality and morbidity.
Co-Authors Agassi Suseno Sutardjo Andree Kurniawan ANINDITA WICITRA Ari Fahrial Syam GRACE SHALMONT Khie Chen Lady P. Sukmawidowati Nata Pratama Primasari Deaningtyas Widiarti S. Soemarno