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Journal : Budapest International Research in Exact Sciences (BirEx Journal)

Exploration of the Analgesic and Antipyretic Effects of Mangosteen Peel Methanol Extract (Garcinia mangostana L) in Male Wistar Rats Jiang Fan; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2634

Abstract

Analgetic-antipyretic is a compound that is often used to reduce pain and fever. A natural plant that has the potential as an antipyretic analgesic compound is mangosteen fruit (Garcinia mangostana L). This study aims to find out the analgesic and antipyretic effects of mangosteen peel methanol extract on male Wistar rats. This type of research is experimental, design Post-Test Only Control Group Design. The research was conducted at the Pharmaceutical Laboratory of the University of North Sumatra Medan, January - March 2021. The test was conducted using 25 mice divided into 5 groups. Data analysis uses SPSS test one-way ANOVA if the data does not distribute normal Kruskal-Wallis. The results of the study 5 hours after treatment, the body temperature of the mice experienced a significant change, the value of P < 0.05 (Value P = 0.004). Where the methanol extract group of mangosteen skin III showed the lowest body temperature 5 hours after treatment which was 36.14 ± 0.12oC and the methanol extract group Mangosteen-III skin also showed a significant difference to the control group that showed the highest body temperature of 37.36 ± 0.46oC. The least amount of geliat found in the mangosteen-III skin methanol extract group was 5.22 ± 1.91 and this number showed a significant difference with the mangosteen- I skin methanol extract group (12.81 ± 3.12) and the control group (11.10 ± 1.91). In conclusion, the results of mangosteen skin testing have antipyretic and antipyretic effects, found at 5 hours after treatment and the highest dose is 750 mg/ kgBB. Meanwhile, the results of the hematologic examination showed a significant decrease in line with the increase in the dose of mangosteen skin methanol extract given.
Analysis of Factors Related to the Risk of Hypertension Events at Royal Prima Medan Hospital in 2021 Li Wei; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2660

Abstract

Hypertension is estimated to be the cause of death of 7.1 million people worldwide or about 13% of the total death. The purpose of the study is to find out the analysis of factors related to the risk of hypertension events. This type of quantitative research is a non-experimental descriptive approach. The study was conducted at Royal Prima Hospital, April-June 2021. The study population of all inpatients/street, Structural Equation Modelling (SEM) sampling technique sample numbered 200 people. Instrument research tension meter, stethoscope, digital scales, meter, and questionnaire. Bivariate (Chi-square) and multivariate (multiple logistic regression) analysis, 0.05 degree of confidence. The results of statistical tests using Chi-Square, the majority of respondents aged 56-65 years 124 people (62%), p-value 0,000, the majority of female respondents are 141 people (72%), p-value 0,000, the majority of respondents have a history of hypertension in the family of 161 people (81%), p-value 0,006, the majority of respondents do not smoke 146 people (73%), p-value 0,044, the majority of respondents dietary patterns rarely consume fat by 156 people (78%), p-value 0.026, the majority of respondents did not consume alcohol 171 people (86%), p- value 0.016, these variables had a meaningful relationship with p-value < 0.05. While the majority of obese respondents amounted to 138 people with a percentage (69%), had no association with p-value 0.117 (>0.05). In the results of multivariate analysis, the most dominant factor determining the incidence of hypertension is the sex variable, p-value (0.000) < 0.05, or value 21,200, meaning that the sex has a 21,200 chance of developing hypertension. Conclusions of research variables age, gender, family history, smoking, diet, alcohol consumption have an association with the incidence of hypertension, the most dominant factor is gender. It is expected that all communities can still maintain a healthy lifestyle, to avoid various diseases, especially non-communicable diseases.
Test the Cardioprotective Effectiveness of Turmeric Ethanol Extract (Curcuma Longa) in Doxorubicin-In-Rat Wistar (Rattus Norvegicus) Doxorubicin-Induced Males Wang Xiqin; Florenly Florenly; Liena Liena; Johannes Bastira
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2661

Abstract

Cardiotoxicity is mostly due to the use of chemotherapy drugs, with the class of anthracyclines drugs being 86.8. One of the most commonly used anthracyclines is doxorubicin. Turmeric with the scientific name Curcuma longa linn is one of the medicinal plants, the main compound is curcumin is considered able to reduce the risk of heart attack. The goal of this study tested the cardioprotective effectiveness of turmeric ethanol extract (curcuma longa linn.) in doxorubicin-induced male wistar (rattus norvegicus) mice. This type of research is experimental, in the Pharmacology Laboratory of the Faculty of Pharmacy, University of North Sumatra, and November 2020. Animals experimented on male wistar rats (Rattus norvegicus) weighing 150 - 200 grams. Data analysis, if (P > 0.05), continued with One Way ANOVA, but if (P <.05) followed by the Tukey HSD Post Hoc test to see real differences between treatments. If the distributed data is abnormal then the Kruskal-Wallis test results are used. Statistical test results, serum levels of CK–MB in the normal group have significant differences (p<0.05) with the negative control treatment group and the treatment group I, but do not have a significant difference (p>0.05) with the positive control group, treatment group II and the treatment group III. Concluding that turmeric ethanol extract has the ability to lower levels of biomarkers of heart damage namely CK-MB and LDH induced with doxorubicin, gradually increasing doses of turmeric ethanol extract can reduce the incidence of heart cell damage, which is most effective at doses of EEK 500 mg / kg BB. Turmeric ethanol extract has cardioprotective effects induced with doxorubicin. Administration of turmeric ethanol extract can repair heart organ tissue induced with doxorubicin based on histological picture of the heart. It is hoped that researchers will be able to conduct research on the toxic effects of giving turmeric ethanol extract to the hearts of mice conducted subchronically.