Garuda - Garba Rujukan Digital

KARAKTERISTIK PASIEN OSTEOARTRITIS DI POLIKLINIK ORTOPEDI RS ROYAL PRIMA MEDAN Liena Liena
Jurnal Keperawatan Priority Vol. 4 No. 2 (2021)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v4i2.1902

Osteoarthritis is a degenerative joint disease caused by the breakdown of joint cartilage, usually occurs in the spine, hips, knees, and ankles. This study aims to determine Overview Osteoarthritis Patient Characteristics Polyclinic Prima Royal Orthopaedic Hospital Medan. This study is a descriptive retrospective case study design with a sample of 100 samples were taken by purposive sampling is the most complete data. This study, obtained the highest age group 56-65 years of age by the amount of 41% by 41 people. Meanwhile, the lowest number in the 26-35 year age. This study, obtained the highest age group 56-65 years of age by the amount of 41% by 41 people. Meanwhile, the lowest number in the 26-35 year age that is 1% (1 people). Most gender is female 70% (70 people). Most jobs are housewives is 44% (44 people). Patients with a genetic history are 78% (78 people). Based on the largest weight factor is obese or overweight with 74% (74 people). The main complaint is joint pain as much as 100% (100 people). The most additional complaint is morning stiffness is 75% (75 people). Distribution of osteoarthritis patients based on the results of investigations that most anatomical changes occur joints by 77% (77 people). In Osteoarthritis patients are encouraged to maintain a healthy weight ideal and there should be an outreach to the community about Osteoarthritis society as much as possible in order to avoid factors originators.

Potency of Black Soybean (Glycine max (L.) Merr) Extract and Daidzein as Antioxidant and Antihyaluronidase Tandiah Asan; I Nyoman Ehrich Lister; Edy Fachrial; Annisa Amalia; Wahyu Widowati; Buter Samin; Liena Liena
Majalah Obat Tradisional Vol 24, No 1 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Black soybean (Glycine max (L.) Merr.) is a plant that is widely planted and consumed in Indonesia. In addition, black soybean has unique content of isoflavones, such as daidzein, which is one of the active compounds that have the effect of fighting free radicals and can inhibit the aging process. The purpose of this study is to analyze the antioxidant potency possessed by black soybean extract (BSE) and daidzeinin inhibiting aging of the skin. The method used is a colorimetric test. The type of antioxidant test used is H2O2 scavenging and inhibiting the activity of the hyaluronidase enzyme for antiaging. BSE has better effectiveness of H2O2 scavenging (IC50: 286.24±11.16 (µg/mL)) than daidzein compound (IC50: 366.16±2.54 (µg/mL)). In the inhibition of hyaluronidase enzyme, the daidzein has more effective activities (IC50: 95.80±3.98 (µg/mL)) compared to BSE (IC50: 152.56±13.98 (µg/mL)). The antioxidant and anti-aging activities possessed by BSE make it possible to be used as a cosmetic ingredient for skin aging therapy.

Test of the Effectiveness of Anti-Dyslipedemia Extract Ethanol Mangosteen Peel (Garcinia Mangostana L.) in Male Mice Fed a High-Fat Diet Zhang Yu; Florenly; Liena; Fioni
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 1 (2022): Britain International of Exact Sciences Journal, January
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i1.539

Dyslipidemia is a major risk factor for atheroscler heart disease, stroke, and is often defined as abnormalities or disruption of lipid metabolism. Garcinia mangostana L. is famous for its anti-inflammatory properties and is used in the treatment of skin infections and wounds. The main phytochemicals present in this species are anisoprenylated xanthone, many reports of biological effects, such as antioxidant, pro-apoptosis, anti-proliferative, anti-nosiseptif, anti-inflammatory, neuroprotective, hypoglycemic, and anti-obesity. This study aims to find out the effectiveness of mangosteen peel ethanol extract as an anti-dyslipidemia in male wistar rats given a high-fat diet. This type of research is experimental with a Pre-test approach and Post-test group only control design. The samples used were mangosteen peel ethanol extract and male wistar rats, with the size of the sample calculated with Federer's formula. Analyze data with the One-Way Anova Test if the data is normally distributed with advanced tests in the form of Post Hoc Tukey HSD tests to see real differences between treatments. The results of the total cholesterol study in the entire treatment group of mice showed a significant difference in P values < 0.05. Triglyceride levels in the entire treatment group also showed significant differences, this can be seen from the value of P < 0.05 (Value P = 0.029). LDL levels also showed significant differences across the treatment group, which can be seen from the P value of < 0.05. HDL levels make a significant difference in the value of P < 0.05 (Value P = 0.029). SGOT and SGPT levels in the entire group of rat treatment showed significant differences, this was seen from the value of P < 0.05. The conclusion that mangosteen peel ethanol extract significantly lowered total cholesterol, triglyceride levels, LDL levels, SGOT levels compared to the control group. Mangosteen peel ethanol extract can significantly increase HDL levels compared to the control group.

Effects of Curcuma Longa Ethanol Extract on Isolated Guinea Pigthile Smooth Muscle in Acetylcholine Induction Zheng Yuebin; Florenly; Liena; Fioni
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 1 (2022): Britain International of Exact Sciences Journal, January
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i1.540

Epidemiological studies show that nearly 20% of the world's population suffers from diseases related to allergies and asthma. The main compound of turmeric is curcumin has several pharmacological properties, antioxidant properties, anti-inflammatory, asthma treatment. The study aimed to determine the effects of ethanol extract Curcuma longa on the smooth muscle of the isolated guinea pigtic trachea in acetylcholine induction. This research method was experimental to observe the relationship of Curcuma longa ethanol extract (EECL) to the relaxing effects of isolated smooth muscle trachea marmot (tracheal ring chain) inserted into a bath organ filled with Kreb's physiological fluid by maintaining a temperature of 35-370C and associated with a Matlab recorder. Samples used by male guinea pigs and ethanol extract Curcuma longa (EECL). The results of the study that ethanol extract Curcuma longa has a relaxing effect on the smooth muscles of the trachea isolated from the experimental rats contracted with acetylcholine. Ethanol extract Curcuma longa has the ability not dising from theophylline 2 x 10-4 M in reducing smooth muscle contraction of insulated Cavia porcelain trachea induced by acetylcholine, acetylcholine strength without incubation contraction compared to acetylcholine with EECL incubation showed statistically different results (p <0.05). The mechanism of Curcuma longa relaxation effect on isolated guinea pig smooth muscle is mediated through inhibition of the enzyme PDE.

Anti-Dislipidemia Effectiveness Test of Turmeric Ethanol Extract (Curcuma Longa) in Male Wistar Mice Given a High-Fat Diet Wang Lei; Florenly; Liena; Fioni
Britain International of Exact Sciences (BIoEx) Journal Vol 4 No 1 (2022): Britain International of Exact Sciences Journal, January
Publisher : Britain International for Academic Research (BIAR) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/bioex.v4i1.543

Dyslipidemia is a condition of increasing levels of Low Density Lipoprotein (LDL), cholesterol in the blood, or triglycerides in the blood that can be accompanied by a decrease in levels of High Density Lipoprotein (HDL). Herbal products have been used since long ago in the medical world, one of which is curcuma longa root. The main compound of turmeric is curcumin which can lower cholesterol levels due to inhibiting cholesterol reabsorbtion from the outside and increase the enzyme HmgCoA reductase inhibitor so that fat synthesis can run properly. The purpose of this study was to find out the effectiveness of turmeric ethanol extract (Curcuma Longa) as an anti-dyslipidemia in male wistar rats given a high-fat diet. This experimental study with the pre-test and post-test group only control design approach was conducted in January 2021, at the Herbarium Medanese FMIPA USU. The size of the sample was calculated by Federer's formula, with at least 4 mice in each treatment group. The results and conclusions of turmeric ethanol (Curcuma Longa) III (150.20 ± 0.90 mg/dl) significantly decreased total cholesterol compared to the control group (177.50 ± 6.02mg/dl) (P value < 0.05). Turmeric ethanol extract (Curcuma Longa) III (110.00 (109-112) mg/dl) may significantly lower triglyceride levels compared to the control group (166.50 (160-175) mg/dl), (value P = 0.024). Turmeric ethanol extract (Curcuma Longa) III (66.50 ± 1.25 mg/dl) significantly lowered LDL levels compared to the control group (106.20 ± 3.50 mg/dl), (P value < 0.05). Turmeric ethanol extract (Curcuma Longa) III, (60.00 (59-61) mg/dl) can significantly increase HDL levels compared to the control group (27.00 (33-39) mg/dl), (Value P = 0.024). Turmeric ethanol extract (Curcuma Longa) III significantly lowered SGOT (Value = 0.024) and SGPT (Value P < 0.05) compared to the control group.

Exploration of the Analgesic and Antipyretic Effects of Mangosteen Peel Methanol Extract (Garcinia mangostana L) in Male Wistar Rats Jiang Fan; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2634

Analgetic-antipyretic is a compound that is often used to reduce pain and fever. A natural plant that has the potential as an antipyretic analgesic compound is mangosteen fruit (Garcinia mangostana L). This study aims to find out the analgesic and antipyretic effects of mangosteen peel methanol extract on male Wistar rats. This type of research is experimental, design Post-Test Only Control Group Design. The research was conducted at the Pharmaceutical Laboratory of the University of North Sumatra Medan, January - March 2021. The test was conducted using 25 mice divided into 5 groups. Data analysis uses SPSS test one-way ANOVA if the data does not distribute normal Kruskal-Wallis. The results of the study 5 hours after treatment, the body temperature of the mice experienced a significant change, the value of P < 0.05 (Value P = 0.004). Where the methanol extract group of mangosteen skin III showed the lowest body temperature 5 hours after treatment which was 36.14 ± 0.12oC and the methanol extract group Mangosteen-III skin also showed a significant difference to the control group that showed the highest body temperature of 37.36 ± 0.46oC. The least amount of geliat found in the mangosteen-III skin methanol extract group was 5.22 ± 1.91 and this number showed a significant difference with the mangosteen- I skin methanol extract group (12.81 ± 3.12) and the control group (11.10 ± 1.91). In conclusion, the results of mangosteen skin testing have antipyretic and antipyretic effects, found at 5 hours after treatment and the highest dose is 750 mg/ kgBB. Meanwhile, the results of the hematologic examination showed a significant decrease in line with the increase in the dose of mangosteen skin methanol extract given.

Effectiveness of Ethanol Extract Mangosteen Peel (Garcinia Mangostana L.) in Accelerating Post-Tooth Extraction Healing in Wistar Rats Dong Qian; Florenly Florenly; Liena Liena; Dewi Riastawaty Purba
Budapest International Research in Exact Sciences (BirEx) Journal Vol 4, No 1 (2022): Budapest International Research in Exact Sciences, January
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v4i1.3473

Tooth extraction will cause a wound in the form of alveolar bone that opens in the oral cavity. Mangosteen peel has various pharmacological effects such as anti-inflammatory, antioxidant, antidiabetic, and antibacterial. The goal of this study was to find out the effectiveness of Mangosteen Peel Ethanol Extract (Garcinia mangostana L.) 45% with 90% in speeding up the healing time of post-tooth extraction wounds in Wistar rats. This type of research is an experimental laboratory with a post-test pattern only control group design. Conducted at the Laboratory of Pharmacology & Laboratory of Traditional Medicine Faculty of Pharmacy, University of North Sumatra January-March 2021. The animal is a male Wistar rat of 32 who is physically healthy. The size of the sample is determined by Federer's formula, the minimum sample size for each treatment is 16 rats. The results of the study that there is a significant relationship between the amount of fibroblast tissue per field of view in Wistar Rats after tooth extraction with the administration of mangosteen peel (Garcinia mangostana L.) with a concentration of 45% and mangosteen peel (Garcinia mangostana L.) concentration 90%, p = 0.036 (p<0.05). Mangosteen skin extract (Garcinia mangostana L.) is 45% and 90% effective in speeding up wound healing time after extraction of rat teeth Wistar. Mangosteen skin extract (Garcinia mangostana L.) is 90% more effective than turmeric extract (Curcuma longa) 45% in speeding up wound healing time post-extraction of rat teeth Wistar due to the flavonoid content in mangosteen skin extract (Garcinia mangostana L.) 90% which helps accelerate wound healing higher than skin extract Mangosteen (Garcinia mangostana L.) 45%.

Analysis of Factors Related to the Risk of Hypertension Events at Royal Prima Medan Hospital in 2021 Li Wei; Florenly Florenly; Liena Liena; Fioni Fioni
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2660

Hypertension is estimated to be the cause of death of 7.1 million people worldwide or about 13% of the total death. The purpose of the study is to find out the analysis of factors related to the risk of hypertension events. This type of quantitative research is a non-experimental descriptive approach. The study was conducted at Royal Prima Hospital, April-June 2021. The study population of all inpatients/street, Structural Equation Modelling (SEM) sampling technique sample numbered 200 people. Instrument research tension meter, stethoscope, digital scales, meter, and questionnaire. Bivariate (Chi-square) and multivariate (multiple logistic regression) analysis, 0.05 degree of confidence. The results of statistical tests using Chi-Square, the majority of respondents aged 56-65 years 124 people (62%), p-value 0,000, the majority of female respondents are 141 people (72%), p-value 0,000, the majority of respondents have a history of hypertension in the family of 161 people (81%), p-value 0,006, the majority of respondents do not smoke 146 people (73%), p-value 0,044, the majority of respondents dietary patterns rarely consume fat by 156 people (78%), p-value 0.026, the majority of respondents did not consume alcohol 171 people (86%), p- value 0.016, these variables had a meaningful relationship with p-value < 0.05. While the majority of obese respondents amounted to 138 people with a percentage (69%), had no association with p-value 0.117 (>0.05). In the results of multivariate analysis, the most dominant factor determining the incidence of hypertension is the sex variable, p-value (0.000) < 0.05, or value 21,200, meaning that the sex has a 21,200 chance of developing hypertension. Conclusions of research variables age, gender, family history, smoking, diet, alcohol consumption have an association with the incidence of hypertension, the most dominant factor is gender. It is expected that all communities can still maintain a healthy lifestyle, to avoid various diseases, especially non-communicable diseases.

Test the Cardioprotective Effectiveness of Turmeric Ethanol Extract (Curcuma Longa) in Doxorubicin-In-Rat Wistar (Rattus Norvegicus) Doxorubicin-Induced Males Wang Xiqin; Florenly Florenly; Liena Liena; Johannes Bastira
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 4 (2021): Budapest International Research in Exact Sciences, October
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i4.2661

Cardiotoxicity is mostly due to the use of chemotherapy drugs, with the class of anthracyclines drugs being 86.8. One of the most commonly used anthracyclines is doxorubicin. Turmeric with the scientific name Curcuma longa linn is one of the medicinal plants, the main compound is curcumin is considered able to reduce the risk of heart attack. The goal of this study tested the cardioprotective effectiveness of turmeric ethanol extract (curcuma longa linn.) in doxorubicin-induced male wistar (rattus norvegicus) mice. This type of research is experimental, in the Pharmacology Laboratory of the Faculty of Pharmacy, University of North Sumatra, and November 2020. Animals experimented on male wistar rats (Rattus norvegicus) weighing 150 - 200 grams. Data analysis, if (P > 0.05), continued with One Way ANOVA, but if (P <.05) followed by the Tukey HSD Post Hoc test to see real differences between treatments. If the distributed data is abnormal then the Kruskal-Wallis test results are used. Statistical test results, serum levels of CK–MB in the normal group have significant differences (p<0.05) with the negative control treatment group and the treatment group I, but do not have a significant difference (p>0.05) with the positive control group, treatment group II and the treatment group III. Concluding that turmeric ethanol extract has the ability to lower levels of biomarkers of heart damage namely CK-MB and LDH induced with doxorubicin, gradually increasing doses of turmeric ethanol extract can reduce the incidence of heart cell damage, which is most effective at doses of EEK 500 mg / kg BB. Turmeric ethanol extract has cardioprotective effects induced with doxorubicin. Administration of turmeric ethanol extract can repair heart organ tissue induced with doxorubicin based on histological picture of the heart. It is hoped that researchers will be able to conduct research on the toxic effects of giving turmeric ethanol extract to the hearts of mice conducted subchronically.

Effect of Respiratory Relaxation Techniques on Pain Adaptation in Maternity Mothers at RSU Royal Prima in 2020 Wang Chunxiang; Florenly Florenly; Liena Liena; Dewi Riastawaty Purba
Budapest International Research in Exact Sciences (BirEx) Journal Vol 4, No 1 (2022): Budapest International Research in Exact Sciences, January
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v4i1.3476

Every year an estimated 529,000 women die as a result of complications arising from pregnancy and childbirth. Labor pain is a physiological condition, an unpleasant feeling that occurs during labor. Nonpharmacological pain management can increase satisfaction during labor because the patient can control his feelings and strength, one of which is the texture of respiratory relaxation. The purpose of this study was to find out the effect of respiratory relaxation techniques on pain adaptation in maternity mothers. This type of research is descriptively correlational, using the One Group Pretest-Postest approach. Location in RSU Royal Prima Jalan Ayahanda Number 68A, Sei Putih Tengah, Medan Petisah, North Sumatra, september - November 2020. The population of 43 people, determining the number of samples with the formula slovin, so that the sample was obtained as many as 30 people. The data analysis used is a normality test using the Shapiro Wilk test, because the number of samples is <50. Bivariate analysis of the data is distributed normally using an at-dependent test (paired t-test), while if the data is not distributed normally using the Wilcoxon Signed Rank Test, with a meaningful limit of <0.05. The results of the study score change in the level of pain Wilcoxon test results at the time of the pre-test test the result of a mean value of 3,466, at the time of the post-test test the mean value of 3,166. So the result of the value Z = -2,714 then p-value as much as 0.007<0.05 so that it is concluded ho rejected and Ha received, which means there is an effect of giving respiratory relaxation techniques to changes in pain in maternity mothers when-I at RSU Royal Prima in 2020.

Title

Found 11 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 11 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 11 Documents
Search