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Sutarmo Setiadji
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Medicine & Pharmacology

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The impact of β-hCG on placental angiogenesis in pre-eclampsia Subakir, Sri B.; Jauhari, Tri; Iriana, Pramita; Siagian, Minarma; Setiadji, Sutarmo
Medical Journal of Indonesia Vol 14, No 2 (2005): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.131 KB) | DOI: 10.13181/mji.v14i2.175

Abstract

Numerous factors, such as VEGF and intra-placental oxygenation, can influence placental angiogenic activity. Early in the normal gestation period, β-hCG enhance VEGF activity to induce angiogenesis. The aims of this study were to identify the correlation between β-hCG concentration in placental culture and placental angiogenic activity in pre-eclampsia. Ten placenta samples from women with pre-eclampsia and l0 from controls (normal pregnancy) were collected. All subjects agreed to participate in this study and signed an informed consent form. β-hCG concentration in supernatant of placental culture was measured by Microparticle Enzyme Immunoassay (MEIA) and placental angiogenic activity was measured by endothelial cell migration toward placental explant (score 0-4). The results showed that the median score of placental angiogenic activity in pre-eclampsia was significantly higher than in normal pregnancy (p<0.05). Concentration of β-ahCG in pre-eclampsia was significantly higher than in normal pregnancy (p<0.001). hCG concentration in placental culture was positively correlated to placental angiogenic activity both in pre-eclampsia (r=+0.50) and in normal pregnancy (r=+0.57). Althouglt the correlations were weak, β-hCG is considered one of the factors that influence placental angiogenic activity. (Med J Indones 2005; 14: 67-70)Keyvords: angiogenesis, β-hCG, plocenta, pre-eclampsia
Co-Authors Minarma Siagian Pramita Iriana Sri B. Subakir Tri Jauhari