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All Journal Media Farmasi Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal farmasi UIN Alauddin Makassar
Muthmainnah B
STIKES Nani Hasanuddin
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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SUMBER ALTERNATIF BAHAN BAKU OBAT DIABETES MELLITUS DARI FUNGI ENDOFIT TANAMAN MAHONI (Swietenia mahagoni Jacq) DAN UJI AKTIVITAS INHIBITOR α-GLUKOSIDASE Muthmainnah B
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 4 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i4.2252

Abstract

Eksploitasi terhadap tanaman telah dilakukan sejak ribuan tahun dalam rangka pencarian bahan baku obat. Pencegahan eksploitasi berlebihan dapat dilakukan dengan cara pengembangan sistem fungi endofit. Mikroorganisme dalam hal ini endofit perlu digali dan dikembangkan, mengingat kebutuhan bahan baku obat yang semakin meningkat baik jumlah maupun macamnya. Fungi endofit yang hidup dalam tanaman dapat menghasilkan senyawa metabolit sekunder sama dengan yang dihasilkan inangnya akibat adanya pertukaran genetis dan hubungan evolusi yang panjang. Hasil penelusuran dari beberapa tanaman yang berkhasiat sebagai obat antidiabetes salah satunya adalah mahoni. Salah satu cara kerja obat antidiabetes adalah menghambat pencernaan karbohidrat kompleks (amilum) menjadi glukosa  sehingga asupan glukosa dari usus ke dalam darah dapat dikurangi. Senyawa aktif yang memiliki aktivitas seperti ini misalnya inhibitor alpha glukosidase. Tujuan penelitian ini untuk memperoleh isolat fungi endofit dari tanaman mahoni (Swietenia mahagoni Jacq) yang mampu menghasilkan senyawa metabolit yang memiliki aktivitas inhibitor α-glukosidase. Isolat fungi endofit diperoleh melalui tahapan isolasi fungi endofit, pemurnian, produksi metabolit sekunder, ekstraksi metabolit sekunder sedangkan pada pengujian inhibisi α-glukosidase dengan membandingkan dengan obat paten dengan metode spektrofotometri. 
SKRINING FITOKIMIA SENYAWA METABOLIT SEKUNDER DARI EKSTRAK ETANOL BUAH DELIMA (Punica granatum L.) DENGAN METODE UJI WARNA Muthmainnah B
Media Farmasi XXX Vol 13, No 2 (2017): Media Farmasi
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.338 KB) | DOI: 10.32382/mf.v13i2.880

Abstract

Telah dilakukan penelitian skrining fitokimia ekstrak etanol buah delima (Punica granatum L.) yang diperoleh dari Desa Ongkoe Kabupaten Wajo. Penelitian ini bertujuan untuk mengetahui senyawa metabolit sekunder meliputi flavanoid, alkaloid, terpenoid, steroid, saponin dan tanin pada ekstrak etanol buah delima (Punica granatum L.). Penelitian diawali dengan pengolahan buah delima (Punica granatum L.) menjadi simplisia serbuk dengan melalui tahap sortasi basah, pencucian, pengeringan dan sortasi kering. Selanjutnya penelitian dilakukan dengan menggunakan pelarut etanol 70% dengan perbandingan 1:3 selama 5 hari dengan metode ekstraksi. Penelitian ini dilakukan dengan mengekstraksi simplisia serbuk buah delima (Punica granatum L.) dengan menggunakan metode maserasi (perendaman) dengan pelarut etanol 70% sedangkan identifikasi senyawa metabolit sekunder dilakukan skrining fitokimia dengan uji warna menggunakan berbagai pereaksi. Hasil penelitian menunjukkan bahwa senyawa metabolit sekunder pada ekstrak etanol buah delima (Punica granatum L.) positif mengandung flavonoid, alkaloid, terpenoid, saponin dan tanin sedangkan pada uji steroid diperoleh hasil yang negatif. Kesimpulannya yaitu ekstrak etanol buah delima (Punica granatum L.) mengandung flavanoid,alkaloid, terpenoid, saponin dan tanin.
Uji pH dan Nilai SPF ( Sun Protecting Factor) Terhadap Krim Sunblock Ekstrak Daun Kelor (Moringa oleifera L.) Muthmainna B; Ardilla Amra
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.13512

Abstract

pH is an important parameter in cosmetic products because it is very high or low pH can caused skin irritation. SPF (Sun Protecting Factor) is a universal indicator that describes the effectiveness of a product or substance that is UV protector. The Moringa plant which has a Latin name called Moringa oleifera or in English it is called a drumstick plant is a plant that is a vegetable that is full of nutrients and has various types of uses. This study aims to determine the pH levels and SPF (Sun Protecting Factor) values contained in the sunblock cream of Moringa leaf extract (Moringa oleifera L.). In this study, pH levels were tested by weighing sunblock cream with a concentration of 1%, 3%, 5% then dissolved into aquadest and then tested for pH levels using a pH meter which resulted in pH levels of 6.89 for a concentration of 1%, 6.73 for a concentration of 3% and 6.60 for 5% concentration. While the determination of the SPF (Sun Protecting Factor) value was carried out by weighing the sunblock cream with a concentration of 1%, 3%, 5% then dissolved in ethanol then precipitated using a centrifuge and the absorption was measured using a spectrophotometer which resulted in a SPF (Sun Protecting Factor) value of 7.012 with the category of extra protection, for 1% concentration that 7.275 with extra protection category for 3% concentration and 9.397 with maximum protection for 5% concentration.
Formulasi Sediaan Sabun Padat Herbal Dari Serbuk Kulit Buah Pisang Ambon (Musa paradisiaca var. sapientum L.) Muthmainna B
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15214

Abstract

Most of the soaps in the market are chemical soaps. Chemical soap is a soap that uses Sodium Laurat Sulposphat (SLS) as its main raw material. Ambon banana is a type of banana that is widely consumed by the people of Indonesia. Ambon banana (Musa paradisiaca var. sapientum (L.) Kunt.) are also known to contain saponin, glycoside, tannin, alkaloid, and flavonoid. Ambon banana peel has a higher antioxidant activity than the pulp. The purpose of this study was to evaluate the formula of herbal solid soap from Ambon banan peel powder. This type of research is experimental using a simple formula design. The activity stage includes sample processing, product manufacture, and product quality analysis testing. The test includes an organoleptic test where the results of the data obtained are brown yellow solid soap, greentea lily scent, smooth texture, and rectangular shape, the pH test has an alkaline pH of 9, foam height test has a foam height of 125 mm, 15% water content test, and irritation test that does not cause irritation to the skin of the panliests. From the results of the research that has been done, it can be concluded that the soap formula used meets the requirements of the SNI standard which is safe and good for use on human skin.
Co-Authors Ardilla Amra