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All Journal Alchemy : Journal of Chemistry Orbital: Jurnal Pendidikan Kimia Stannum : Jurnal Sains dan Terapan Kimia
Ana Mardliyah
UIN Walisongo Semarang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Materials Science & Nanotechnology

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PENDEKATAN “MIKiR” UNTUK MENINGKATKAN KEAKTIFAN BELAJAR DALAM PEMBELAJARAN ONLINE PADA PERKULIAHAN KIMIA ORGANIK POKOK BAHASAN SENYAWA ALDEHIDA DAN KETON Sri Mulyanti; Resi Pratiwi; Ana Mardliyah
Orbital: Jurnal Pendidikan Kimia Vol 5 No 1 (2021): Orbital: Jurnal Pendidikan Kimia
Publisher : Chemistry Education Department of Education and Teaching Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/ojpk.v5i1.7460

Abstract

Organic chemistry course is a compulsory subject for chemistry education students. One of the main points of discussion is aldehyde and ketone compounds including the concept of structure, numbering, and nomenclature. With a pandemic condition that demands online lectures, the research team is trying to implement the MIKiR approach online as a solution to making organic chemistry courses interesting, student-centered, and able to achieve learning goals very well. A series of activities with the MIKiR approach have been carried out including introduction, connection, application, and reflection. The results of the evaluation showed that students mastered the concepts of aldehyde and ketone compounds very well with an average value of 80-100%, through a multiple choice test with google form media. After the implementation of the implementation of the MIKiR approach, students were given a questionnaire related to the implementation of lectures, the results of the questionnaire included 59.28% agreeing responses, 32.13% strongly agree, and 8.59% disagree with the implementation of the MIKiR approach in organic chemistry lectures. It can be concluded that the MIKiR approach can be recommended for lecturers in carrying out organic chemistry courses online.
The Toxicity Test on Larvae of Shrimp (Artemia salina L.) of Lindur Fruit Peel Extract (Bruguiera gymnorrhiza) and Identification of Its Bioactive Compounds Ana Mardliyah; Undri Rastuti; Santi Nur Handayani
Stannum : Jurnal Sains dan Terapan Kimia Vol 3 No 2 (2021): Oktober 2021
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v3i2.2548

Abstract

Indonesia is the most mangrove-rich country, both in terms of area quantity and number of species. Mangrove plants have potential as a source of medicinal compounds. Bruguiera gymnorrhiza is a type of mangrove plant which is a source of medicinal plants from the Rhizoporaceae family. Ethanol extract of the stem bark of B. gymnorhiza has been known to have cytotoxic activity with an IC50 of 508.19 µg/mL against myeloma cancer cells (Rahmah, 2021). The aim of this study was to determine the toxicity of lindur fruit peel extract (B. gymnorrhiza) on Artemia salina Leach shrimp larvae. Lindur fruit peel extraction was carried out by maceration method using methanol solvent which was then fractionated with n-hexane and ethyl acetate as solvent. All extract fractions obtained were then tested for toxicity against shrimp larvae Artemia salina Leach by BSLT (Brine Shrimp Lethality Test) method. Extract fractions with the highest toxicity were identified for their bioactive compounds using UV-Visible and FT-IR spectrophotometers. The results of the toxicity test showed that the lindur fruit peel extract was toxic to A. salina L. and the most toxic fraction was the n-hexane fraction with an LC50 value of 34.109 ppm. The results of the analysis using UV-Visible and FT-IR spectrophotometers the active compound in the hexane fraction of lindur fruit extract (B. gymnorrhiza) contains terpenoid which has double bond conjugated that showed by the existence of an electronic transition of π →π* that was conjugated and there are clusters of -OH, C=O, C=C, aromatic, C-H and C-O groups.
Sintesis Senyawa Vanilil Metil Keton dan Uji Aktivitas Antiinflamasi terhadap Enzim COX-1 dan COX-2 melalui Analisis In Silico Khoirotul Ummah; Robby Gus Mahardika; Ana Mardliyah
ALCHEMY:Journal of Chemistry Vol 8, No 2 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v8i2.10863

Abstract

This study reports the synthesis of vanillyl methyl ketone from eugenol through Wacker oxidation and anti-inflammatory activity test toward COX-1 and COX-2 through in silico analysis. Wacker oxidation process was catalyzed by PdCl2 and CuCl2 using DMF solvent under the aerobic condition at room temperature for 48 hours. The product of the synthesis was purified by column chromatography and was characterized by NMR, IR, and MS spectroscopy. Characterization by spectroscopic methods showed that vanillyl methyl ketone was formed with a yield of 45% and vanillin (3%) was produced as a by-product. The anti-inflammatory activity of vanillyl methyl ketone was carried out by molecular docking toward   COX-1 and COX-2 obtained from PDB. The analysis showed that the anti-inflammatory activity and selectivity toward COX-2 of vanillyl methyl ketone was higher than eugenol. This was shown by the low binding energy affinity and the number of hydrogen bonds formed between the vanillyl methyl ketone and the active site of the enzyme. Keywords: eugenol, Wacker, vanillyl methyl ketone, antiinflammatory, in silico Pada penelitian ini dilakukan sintesis senyawa vanilil metil keton dari eugenol melalui oksidasi Wacker serta dilakukan uji aktivitas antiinflamasi terhadap enzim COX-1 dan COX-2 melalui analisis in silico. Proses oksidasi Wacker dikatalisis oleh PdCl2 dan CuCl2 menggunakan pelarut DMF dalam kondisi aerob pada suhu ruang selama 48 jam. Senyawa hasil sintesis dipisahkan menggunakan kolom kromatografi dan dikarakterisasi menggunakan spektroskopi NMR, IR dan MS. Hasil karakterisasi menunjukkan bahwa senyawa vanilil metil keton telah terbentuk dengan randemen sebanyak 45% dan juga dihasilkan senyawa vanillin (3%) sebagai produk samping. Aktivitas antiinflamasi senyawa vanilil metil keton dilakukan dengan docking molekuler terhadap enzim COX-1 dan COX-2 yang diperoleh dari PDB. Hasil analisis menunjukkan bahwa aktivitas antiinflamasi dan selektivitas terhadap COX-2 pada senyawa vanilil metil keton lebih tinggi dibandingkan eugenol. Hal ini ditunjukkan melalui rendahnya afinitas energi pengikatan dan banyaknya ikatan hidrogen yang terbentuk antara vanilil metil keton dengan sisi aktif enzim. Kata kunci : eugenol, Wacker, vanilil metil keton, antiinflamasi, in silico
Co-Authors Khoirotul Ummah Resi Pratiwi Robby Gus Mahardika Santi Nur Handayani Sri Mulyanti Undri Rastuti