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Uji Efek Pelindung Hati Ekstrak Air Tanaman Kulit Lawang, Cinnamomum Cullilaban (Lauraceae), melalui Pemeriksaan MDA dan SOD Plasma Sel Darah Tikus Soeksmanto, Arif
Jurnal Natur Indonesia Vol 13, No 2 (2011)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (47.103 KB) | DOI: 10.31258/jnat.13.2.130-133

Abstract

Industrial growth, pollution, and the change of life style cause environmental degradation. This condition enhancesthe occurrence of degenerative diseases that more difficult to conquer than infective diseases. This promotes theuse of herbs in America up to 385% in period 1990-1997, wasting 4–12 billion dollar each year. World HealthOrganization (WHO) estimates approximately 4 billion or 80% of world citizens use herbs for their health care. Kulitlawang plants are medicinal plants grown endemically in Papua and Maluku regions. The existence of the plants inMaluku islands is considered as endangered species. Information on the plants in scientific publication is relativelylimited. meanwhile Cinnamomum sp. is known having high antioxidant compound. This research aimed to find outhepatoprotector effect of kulit lawang water extract through observation of MDA and SOD of venous blood of ratintoxicated with CCl4. Dosage used was based on result of effective dosage test which showed that water extractof kulit lawang plant of 20 mg/kg bw as highest dosage that did not harm animal health. Result of hepatoprotectoreffect test showed that MDA and SOD of control were 230.12 U/ml and 1243.00 ρmol/ml, whereas water extract ofkulit lawang was 414.45 U/ml and 793.00 ρ mol/ml, á-tocopherol 416.42 U/ml and 782.33 ρmol/ml, and curcumin426.07 U/ml and 734.00 ρmol/ml. This showed that water extract of kulit lawang plant has antioxidant propertiesand potential as hepatoprotector of oxidative damage.
Uji Toksisitas Akut Ekstrak Air Tanaman Sarang Semut (Myrmecodia pendans) Terhadap Histologi Organ Hati Mencit Soeksmanto, Arif; Simanjuntak, Partomuan; Subroto, Muhammad Ahkam
Jurnal Natur Indonesia Vol 12, No 2 (2010)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (69.325 KB) | DOI: 10.31258/jnat.12.2.152-155

Abstract

erbal products in powder or capsule forms made of sarang semut plant have been widely distributed in market.This plant is believed to treat several diseases, such as cancer, gout, liver, stroke, heart, hemorrhoid, back pain,allergy, and as tonicum to increase sexual desire. Information on the plants was still limited on plant distribution,ecology, ethnobotany, and taxonomy, without research on toxicity and clinical aspect. Considering that sarangsemut products has been distributed at market and limited scientific publication of the plant, hence acute toxicitytest of sarang semut extract should be conducted. The results showed that dose of 375 mg/kg bw caused liverdegeneration on day-5 and normal on day-19. Whereas dose of 3750 mg/kg bw caused cell necrosis up to day-12,degeneration still apparent on day-26.
Pemulihan Kerusakan Jaringan Hati Mencit yang Diberi Ekstrak Butanol Buah Tua Mahkota Dewa Soeksmanto, Arif
Jurnal Natur Indonesia Vol 10, No 1 (2007)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.312 KB) | DOI: 10.31258/jnat.10.1.53-57

Abstract

Mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.) is an Indonesians traditional medicinal plant used to treat various diseases, such as diabetes mellitus, hemorrhoid, impotency and cancer. Almost all parts of the plants canbe used as traditional medicine, but if directly consumed, it can cause swollen, sprue, numb at tongue, fever, even unconsciousness. This research was carried out to find out recovery of liver tissue damage of mice administered intraperitoneally with subchronic dosage of butanol extract 170 mg/kg body weight. Observation on first week showed that there is light degeneration (vacuolization) which is getting better on second week and apparentlynormal on forth week.