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All Journal Indonesian Journal of Cardiology
Amiliana M Soesanto
Faculty of Medicine, University of Indonesia/ Harapan Kita National Cardiovascular Center
Health Professions Medicine & Pharmacology

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Insiden gejala menetap dan gambaran ekokardiografi pasca infensi COVID-19 ringan Almazini, Prima; Soesanto, Amiliana M; Kuncoro, Ario S; Ariani, Rina; Rudiktyo, Estu; Sukmawan, Renan
Jurnal Kardiologi Indonesia Vol 43 No 1 (2022): Indonesian Journal of Cardiology: January - March 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1160

Abstract

Background: Survived from COVID-19 infection, some patients yet have residual symptoms. Multi-organ and mechanisms of disease can be involved. The data regarding echocardiographic dimension and function of the cardiac in the COVID-19 survivors remains scarce. Method: This was a descriptive cross-sectional study that involves a total of 63 subjects. Subjects were employees and medical residents at National Cardiovascular Center Harapan Kita, who previously get infected by COVID-19. Each subject was examined transthoracic echocardiography once at the time of recruitment. Echocardiographic parameters obtained in this study included dimension and systolic function of the left ventricle and right ventricle, global longitudinal strain by 2D speckle tracking echocardiography, and myocardial work index. Result: More than a half of the subjects experienced persistent symptoms after recovery from COVID-19 infection and mainly was fatigue (33.3%). The timing of data acquisition on the median was 32 days after the negative of the COVID-19 test result. 2D echocardiography measurement of left ventricle indicated mean of end-diastolic diameter and end-systolic diameter was 45 mm and 27 mm, respectively. The mean ejection fraction (EF) of the left ventricle by Simpson’s biplane method was 61%. The median of tricuspid annular plane systolic excursion (TAPSE) parameter was 23 mm and the fractional area change (FAC) parameter was 39%. The mean of global longitudinal strain (GLS) was -19.6%. Conclusion: After recovery from COVID-19 infection, some survivors may have post-acute infectious consequences of COVID-19 such as fatigue, dyspnea, and malaise. However, echocardiographic findings in those patients with mild symptoms, including 2D echocardiography, myocardial strain analysis, and myocardial work index, indicate normal dimension and systolic function in both left ventricle and right ventricle.
A Simple Scoring System for Predicting In-Hospital Mortality after Heart Valve Surgery in A Developing Country Soesanto, Amiliana M; Husink, Aron; Ariyanti, Novi; Asmuni, Melyana; Lilyasari, - Oktavia; Hardjosworo, Arinto Bono Adji
Jurnal Kardiologi Indonesia Vol 42 No 4 (2021): Indonesian Journal of Cardiology: October - December 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1174

Abstract

Background: Various scoring systems predict mortality after cardiac surgery, but not many were designed for specific valvular surgery. Developing countries have different characteristics of patients and conditions in cardiac centers compare to developed countries. We aimed to develop a simple scoring system for predicting in-hospital mortality after valve surgery and further validate the scoring system. Methods: For developing the scoring system, the data was taken from the medical record of patient underwent valve surgery in 2012 - 2014, and for the validation study, it was from 2015 to 2016. The scoring system was developed using logistic regression models, then validated using calibration and discrimination analysis. Result: For developing a scoring system, we recruited 1040 patients in the study. The in-hospital mortality rate was 68 (6.5%). Eight variables were incorporated, including; functional class, hypertension, previous open-heart surgery, impaired renal function, right ventricular dysfunction, emergent operation, coronary artery bypass surgery, and tricuspid valve surgery. The mortality risk score has Hosmer Lemeshow (H-L) test p-value = 0.212; AUC = 0.813 (CI 95% = 0.758–0.867); and cut-off point of 5, predicting 14% risk of death (sensitivity 72.1%, specificity 75.3%). In the validation study, 789 subjects were recruited. The observed and predicted mortality were 8.6% and 11.9% respectively, with H-L test p-value = 0.169 and AUC 0.761 (95% CI; 0.702-0.821) Conclusion: We have developed a simple scoring system for predicting in-hospital mortality after valve surgery. The mortality risk score was well-calibrated with a moderate discrimination value in the validation study.
Pengaruh Tricuspid Annular Plane Systolic Excursion (TAPSE) Pasca Pembedahan Katup Mitral Terhadap Mortalitas Jangka Panjang Erriyanti, Sabrina; Soesanto, Amiliana M; Sakidjan, Indriwanto; Atmosudigdo, A.; Lilyasari, Oktavia; Ariani, Rina; Siagian, Sisca Natalia
Jurnal Kardiologi Indonesia Vol 43 No 1 (2022): Indonesian Journal of Cardiology: January - March 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1196

Abstract

Abstract Background: Heart valve disease is still a significant health burden in the world, including Indonesia. The postoperative outcome of mitral valve surgery is influenced by many things, including decreased right ventricular (RV) function, which is the most common complication. Several studies have shown that decreased RV function after mitral valve surgery is associated with long-term outcomes. TAPSE is a routine and easy measurement of RV systolic function. A decrease in TAPSE after cardiac surgery is common because of the effects of pericardiotomy, and does not necessarily reflect a decrease in RV ejection fraction (RVEF). Regardless of whether postoperative TAPSE values ​​indicate right ventricular systolic function or only due to the effects of pericardiotomy, it is still not clear whether postoperative TAPSE values ​​have a prognostic value to long-term mortality after mitral valve surgery. Therefore, the objective of this study is to obtain information regarding the relationship of TAPSE echocardiographic parameters after mitral valve surgery with long-term mortality. Methods: This is a retrospective cohort study, looking at the effect of TAPSE on outcome after mitral valve surgery. The analysis starts from the starting point of the study when the patient was discharged alive from the hospital after mitral valve surgery (operation period January 2016 – February 2017) to the end point of the study, which was June 30th, 2021 and the observed outcome was mortality from any cause. Results: Of the 266 study subjects, 11 subjects died within 4-5 years after mitral valve surgery, the mortality is 4%. Bivariate analysis was performed on several factors and no relationship was found between the analyzed variables and mortality. Conclusion: There is no relationship between mortality and TAPSE after mitral valve surgery. Keywords: TAPSE, Mitral Valve Surgery, Mortality
Does Chronic Inflammation Play a Role in Rheumatic Mitral Valve Restenosis after Percutaneous Transvenous Mitral Commissurotomy? Soesanto, Amiliana M
Jurnal Kardiologi Indonesia Vol 43 No 3 (2022): Indonesian Journal of Cardiology: July - September 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1398

Abstract

ABSTRACT Background: Mitral valve restenosis is defined as decreased mitral valve area (MVA) <1.5 cm2 or decreased MVA >50% after PTMC. It is time-dependent and associated with major adverse cardiovascular events (MACE), such as congestive heart failure, cardiac death, mitral valve replacement, and redo PTMC. The mechanism is not yet known; however, chronic inflammation may have a role. Objective: To know the association between chronic inflammation and mitral valve restenosis after PTMC. Methods: A total of 40 patients with mitral valve stenosis who underwent successful PTMC were matched and classified into restenosis/case group (n=20) and no restenosis/control group (n=20). Secondary data was taken from electronic medical records such as patient characteristics (gender, age & 2nd prophylaxis), echocardiography data before PTMC (Wilkins’ score and MVA before PTMC), and echocardiography data after PTMC (MVA after PTMC). Follow-up echocardiography examination (follow-up MVA) and laboratory assessment of chronic inflammation marker (IL-6) were done on all patients. Statistical analyses were done to look for an association between the level of chronic inflammation marker & other independent variables with mitral valve restenosis. Results: Median IL-6 concentration was 2.39 (0.03 – 11.4) pg/mL. There was no statistically significant difference in IL-6 levels between both groups (p-value >0.05). MVA decrement was 0.13 (0 – 0.62) cm2/year with rate of MVA decrement ≥0.155 cm2/year was predictor of mitral valve restenosis (p-value <0.001, OR = 46.72, 95% CI 6.69 – 326.19). Conclusion: Chronic inflammation assessed by IL-6 was not associated with mitral valve restenosis.
Co-Authors Ariani, Rina Ariyanti, Novi Asmuni, Melyana Atmosudigdo, A. Erriyanti, Sabrina Hardjosworo, Arinto Bono Adji Husink, Aron Indriwanto Sakidjan Kuncoro, Ario S Lilyasari, - Oktavia Oktavia Lilyasari Prima Almazini Renan Sukmawan Rudiktyo, Estu Siagian, Sisca Natalia