The heart is the main organ that must work properly and regularly. If there is interference, it will be fatal, namely the onset of a heart attack. Heart attack is included in the 10 diseases with a high risk of death. This is caused by stress factors, blood pressure, excessive work, blood sugar, and others. The purpose of this study is to predict heart disease using Machine Learning (ML) algorithms as an early preventive measure on desktop-based information systems. With Machine Learning models, the hybrid model can increase the accuracy value of an ML method that is added to other ML methods. The accuracy value obtained from the Hybrid Model Machine Learning using the Random Forest and Logistic Regression methods is 84.48%, which is an increase of 1.32%.