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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Karina Sugih Arto
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Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Gangguan fungsi hormon tiroid pada anak penderita infeksi susunan saraf pusat Rahmad Sumiko; Melda Deliana; Hakimi dr; Siska Mayasari Lubis; Karina Sugih Arto
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Dysfunction of thyroid hormone can occur in children with central nervous system (CNS) infections characterized by decreasing levels of triiodothyronine (T3). Severe CNS infections have symptoms such as seizures, respiratory failure, impaired consciousness, fever, and typical abnormalities on Elektroencephalografi (EEG). Central nervous system infected children with low T3 have tendency of lower survival rate compare to CNS infected children with low thyroxine (T4). Examination of thyroid hormone performed by using vena puncture and lumbar puncture. It was performed before treatment is given. Until now, there are onlyfew case reports of thyroid hormone dysfunction in children with central nervous system infections.Keywords : CNS infection, children, thyroid dysfunction
Correlation between Leptin and Free Testosterone Levels in Transfusion-Dependent Thalassemia Male Patients Lubis, Dian Anindita; Karina Sugih Arto; Heny Syahrini
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 1 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i1.12159

Abstract

Background: Male hypogonadism is a clinical disorder of low testosterone and spermatozoa due to impaired production that can occur at one or more levels in the hypothalamic-pituitary-gonadal (HPG) axis. Apart from iron accumulation, hypogonadism can also occur due to other mechanisms in thalassemia patients, such as the influence of adipose tissue and leptin. The study aimed to assess the relationship between leptin with free testosterone levels and BMI in transfusion-dependent thalassemia. Method: The research design chosen was analytic cross-sectional. The study was conducted at the adult thalassemia polyclinic of Cipto Mangunkusumo General Hospital and Fatmawati General Hospital, during the period July - December 2022. The samples used were male transfusion-dependent thalassemia patients aged over 18 years who were under control at the Thalassemia Polyclinic during the study period. The diagnosis of Thalassemia had been previously established by high-performance liquid chromatography (HPLC) or microcapillary examination. Result: Most patients were major ß thalassemia (87.8%), while HbE ß thalassemia was only 12.1%. Age distribution was with a median of 23 years (minimum-maximum 18-42 years). The clinical symptoms of hypogonadism were erectile dysfunction and decreased libido (12.1% and 9%, respectively). From body mass index examination were underweight 18 (54,5%), normal weight 13 (39,5%), overweight 1 (3%), and obese 1 (3%). Of the 33 transfusion-dependent thalassemia patients, 95% did not reach puberty according to their age (Tanner stage V). Conclusion: There is an association significantly between leptin levels with free testosterone and body mass index in transfusion-dependent thalassemia men.
Co-Authors Hakimi dr Heny Syahrini Lubis, Dian Anindita Melda Deliana Rahmad Sumiko Siska Mayasari Lubis