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All Journal Jurnal Kedokteran Indonesia Nexus Kedokteran Klinik Cermin Dunia Kedokteran
Mulyo Hadi Sudjito
RS Dr. Moewardi
Health Professions Medicine & Pharmacology Public Health

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Pengaruh Pemberian Propofol Intravena 10mg/KgBB, 25 mg/KgBB dan 50 mg/KgBB Terhadap Ekspresi Kaspase 3 Hipokampus pada Mencit Balb/ C Dengan Cedera Kepala Yusriyani, ; Sudjito, Mulyo Hadi; Murti, Bhisma
Jurnal Kedokteran Indonesia Vol 3, No 1 (2012)
Publisher : Jurnal Kedokteran Indonesia

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Background:Head injury is one of the leading causes of death and disability. In head injury there is biomolecularand biochemical pathologic process that can cause necrosis and apoptosis via caspase 3 activation. Propofol is an intravenous anesthetic drug that has neuroprotective mechanism by regulating caspase 3. This study aimed to determine the inhibitory effect of intravenous propofol 10 mg/kgBW, 25 mg/kgBW and 50 mg/kgBW oncaspase 3expression in mice balb/c with head injury. Methods: This was a laboratory experiment using randomized controlled trial design. Asample of 32 Balb/c mices were divided into 4 groups. All groups underwent head injury procedure using weight drop technique. Group 1 did not received propofol. Group 2, 3, and 4 received intravenous 10 mg, 25 mg, and 50 mg/kgBB propofol, respectively. Caspase 3 activation was stained and identified by immunohistochemical technique 6 hours afteradministration of propofol. Difference in mean between groups was tested by One Way Anova and mean pair-wise groups by Post Hoc Test on SPSS 12. Results: Mean caspase 3 expresion in each group was as follow: Group 1=4.08, Group 2= 2.95, Group 3= 2.52, Group 4=1.77. One way Anova showed statistically significant difference in mean caspase 3 expression between groups (p<0.001). The higher dose of propofol, the lower caspase 3. The pair-wise mean difference were as followsGroup1-Group2 (p<0.001), Group1-Group3 (p<0.001), Group1-Group4 (p<0.001), Group2-Group4 (p<0.001), Group3-Group4 (p<0.001), and Group2-Group3 (p=0.232). Conclusion:Administration of intravenous propofol with 10,25,50 mg/kgBW doses were effective to inhibit caspase 3 activity expression in mices with head injury. Higher doses give stronger inhibitory effect, with 50mg/kgBW being the recommended optimal dose. Keywords: caspase 3 expression, propofol, mice, head injury
Efek Anestesi Inhalasi Sevofluran dan Isofluran Terhadap Frekuensi Nadi Fatimah, Aulia Nurul; Sudjito, Mulyo Hadi; Probandari, Ari
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Anesthesia is an important part of the surgery. Sevoflurane and isoflurane are two inhalation anesthesia drugs have been commonly used. During anesthesia, one of indicators should be monitored is frequency of pulse. This research aimed to know the effects of these two drugs to the frequency of pulse. Methods: This research was an analytical observational research with the approach of cross sectional. The sample was taken by consecutive sampling after being selected based on the inclusion and exclusion criteria. Totally, 50 patients were divided into two groups of inhalation anesthetic sevoflurane and inhalation anesthetic sevoflurane and isoflurane. Data was analyzed with independent t test. Results: The p values on t-independent test in the early phase of the pulse frequency, phase induction and phase intubation were 0.04; 0.00; 0.02, and of the phase 5’ of incision, 10’of incision and 15’of incision were 0.02; 0,0; 0.03. This results showed statistical significant of mean of pulse-frequency difference between sevoflurane and isoflurane in each of phase of inhalation anesthesia. Conclusions: Both sevoflurane and isoflurane influence the frequency of pulse. The mean of pulse frequency by isoflurane is higher than sevoflurane. However, inhalation anesthesia sevoflurane provides better stability than isoflurane. Keywords: Anesthetic Inhalation, Frequency of Pulse, Isoflurane, Sevoflurane
Kejadian Mual Muntah Pasca-Laparatomi (PONV) setelah Pemberian Granisetron Dibandingkan setelah Pemberian Kombinasi Ondansetron - Deksametason Sudjito, Mulyo Hadi; -, Mulyata; Setyawati, Titik
Cermin Dunia Kedokteran Vol 45, No 3 (2018): Muskuloskeletal
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.076 KB) | DOI: 10.55175/cdk.v45i3.185

Abstract

Pendahuluan:  Mual  muntah  pasca-operasi  (PONV)  adalah  pengalaman  tidak  menyenangkan  yang  sering  dialami  pasien  setelah  menjalani operasi  dengan  anestesi  umum  seperti  laparatomi. Metode:  Penelitian  desain  eksperimental  tersamar  tunggal;  58  subjek  yang  menjalani laparatomi dengan anestesi umum dibagi menjadi 2 kelompok secara acak. Kelompok I diberi granisetron 1 mg, 30 sampai 60 menit sebelum operasi selesai, kelompok II diberi deksametason 8 mg sebelum induksi dan ondansetron 4 mg, 30 sampai 60 menit sebelum operasi selesai. Kejadian PONV semua pasien diamati selama 24 jam. Hasil: Pada kelompok I mampu dicegah 72,4% kejadian PONV, pada kelompok II mampu dicegah 79,3% kejadian PONV. Simpulan: Tidak ada perbedaan bermakna manfaat ondansetron 4 mg dan deksametason 8 mg dibanding granisetron 1 mg dalam mencegah mual muntah pasca-laparatomi.
Co-Authors -, Mulyata Ari Probandari Aulia Nurul Fatimah Bhisma Murti Setyawati, Titik Yusriyani