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All Journal Indonesian Journal of Rheumatology MEDICINUS
Sukamto Koesnoe
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Serum Nerve Growth Factor in the Occurrence of Peripheral Neuropathy in Rheumatoid Arthritis Patients Rudy Hidayat; Ridho Adriansyah; Ahmad Yanuar Safri; Sukamto Koesnoe
Indonesian Journal of Rheumatology Vol. 12 No. 1 (2020): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v12i1.149

Abstract

Abstract Background Peripheral neuropathy (PN) is an extraarticular manifestation in rheumatoid arthritis (RA). In type-2 diabetes mellitus (DM) patients, Nerve Growth Factor (NGF) is associated with PN. The correlation between NGF level and PN among RA has not been concluded yet. This study aimed to determine the mean levels of NGF blood serum and its relationship to PN among RA patients. Method A cross sectional study using consecutive sampling method including patient of rheumatology clinic Cipto Mangunkusumo Hospital was performed between July 2015 to March 2016. The NGF level measurement and Electromyography-Nerve Conduction Velocities (EMG-NCV) were examined to the subjects. Patients were classified into 2 groups; PN positive and PN negative. Bivariate analysis was done to investigate the relationship between NGF and PN among groups. Secondary data such as age, sex, Erythrocyte Sedimentation Rate (ESR), CRP, Disease Activity Score (DAS)28-ESR and CRP are obtained from medical record. Result Among 132 subjects, PN was found in 60 subjects. The median of NGF level in RA patients was 4.11 pg/mL (0.0-24.5). The median of NGF level of RA patients with PN was 4.11 pg/mL (1.1-20.83) and without PN was 3.89 pg/mL (0.0-24.5). Types of neuropathy among patients were polyneuropathy (21.97%), mononeuropathy multiplex (15.15%) and Carpal Tunnel Syndrome (11.36%). In this study we found no association between NGF serum level and PN among RA patients (p = 0.716). Conclusion The median of serum NGF level among PN group was higher than without PN. There was no relationship between serum NGF level and PN among patients with RA. Keywords :rheumatoid arthritis, peripheral neuropathy, nerve growth factor
Peran Vitamin D dalam Aktivitas Penyakit Lupus Eritematosus Sistemik (LES) Sukamto Koesnoe
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.131 KB) | DOI: 10.56951/medicinus.v35i2.87

Abstract

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that leads to various immune system dysregulation. SLE has complex pathophysiology involving interaction between factors that will produce abnormal immune response. This abnormal immune response results in inflammatory reactions throughout various organs, and this chronic process will lead to tissue and organ damage. Vitamin D has been studied for its’ role as an immunomodulator, therefore it is potential to be part of SLE management.The potential benefits of vitamin D supplementation to improve clinical conditions of SLE patients has been investigated. Some studies showed that there were positive effects after supplementation with vitamin D in SLE patients. This can be explained considering vitamin D deficiency is associated with disease activity and frequency of exacerbations in SLE. Vitamin D’s active form, calcitriol, was found to have an important role in the pathogenesis of SLE. Study found that vitamin D supplementation could help to reduce disease activity and improve clinical condition in SLE patients.
Co-Authors Ridho Adriansyah Rudy Hidayat Safri, Ahmad Yanuar