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All Journal Indonesian Journal of Chemistry
Budi Untari
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, University of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir 30622, South Sumatera, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry

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α-Glucosidase Inhibitory and A Leptospermone Derivative from Rhodomyrtus tomentosa Ferlinahayati Ferlinahayati; Daniel Alfarado; Eliza Eliza; Budi Untari
Indonesian Journal of Chemistry Vol 20, No 2 (2020)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (19.288 KB) | DOI: 10.22146/ijc.40990

Abstract

One of the treatments for diabetes mellitus disease is to control blood sugar level using an inhibitor of α-glucosidase enzyme. The methanol extracts of the fruit, stem, and leaves of Rhodomyrtus tomentosa were found significant in inhibiting α-glucosidase with an IC50 value of 20.57, 20.36 and 43.99 μg/mL respectively. The ethyl acetate and n-butanol fractions from the methanol extract of R. tomentosa fruit exhibited the potent inhibition (IC50 13.49 and 19.29 μg/mL) compare to acarbose and n-hexane fraction (IC50 383.68 and 1175.16 μg/mL). A leptospermone derivative, rhodomyrtosone D, was isolated from the ethyl acetate fraction of R. tomentosa fruit. The structure of rhodomyrtosone D was identified based on spectroscopic analysis, as well as comparing with literature data. The α-glucosidase inhibition of rhodomyrtosone D (IC50 110.45 μg/mL) was 3.5 fold more potent than acarbose. Thus, R. tomentosa plant could be potential as a natural resource of α-glucosidase inhibitor.
Co-Authors Daniel Alfarado Eliza Eliza Ferlinahayati Ferlinahayati