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All Journal ARSHI Veterinary Letters
Pitra Ariesta Shinta Dewi
Doctoral Programme of Biomedical Sciences, Faculty of Medicine, University of Indonesia, Jakarta
Agriculture, Biological Sciences & Forestry Veterinary

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Animal model of diabetic keratopathy Pitra Ariesta Shinta Dewi; Ratna Sitompul; Jeanne Pawitan; Aroem Naroeni
ARSHI Veterinary Letters Vol. 3 No. 3 (2019): ARSHI Veterinary Letters - Agustus 2019
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (564.534 KB) | DOI: 10.29244/avl.3.3.57-58

Abstract

Diabetic keratopathy is one of the most common ocular complications in diabetes mellitus. Protocol for diabetes induction in rat model also has been established in many centers. Nonetheless, method in developing diabetic keratopathy rat model has not been well covered. Streptozotocin (STZ) -induced diabetes is widely being used as animal diabetic model. The purpose of this study is to obtain an animal model of diabetic keratopathy that can be used to study the morphology, metabolism, and function of cornea in cases where human samples can be difficult to obtain. A single dose STZ (50 mg/kg) was injected intraperitoneally to control and intervention group. Plasma glucose level concentrations were tested in day 3 postinjections. Obtained animal model of diabetic keratopathy, with significant difference of blood glucose level between intervention and control group (P<0.00). Sensibility of cornea was decreased by week 14th in intervention group. Epithelial defect were more prominent in diabetic group. Despite the differences between human and animal characteristic of diabetic keratopathy, the use of animal models has contributed to better understanding of this disease and to examine more effective treatment.
Co-Authors Aroem Naroeni Jeanne Pawitan Ratna Sitompul