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All Journal Jurnal Ilmiah Farmasi Akademi Farmasi Jember
Rosida hari
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Medicine & Pharmacology

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PROFIL KADAR TRIGLISERIDA PASIEN HIPERTRIGLISERIDEMIA SETELAH PENGGUNAAN GEMFIBROZIL 300 mg DI POLIKLINIK PRATAMA POLITEKNIK NEGERI JEMBER Rosida hari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 4, No 1 (2021): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.801 KB) | DOI: 10.53864/jifakfar.v4i1.44

Abstract

Penyakit kardiovaskular merupakan penyebab kematian utama didunia dan jumlah kasus penyakit ini telah mengalami peningkatan selama satu decade terakhir. Salah satu penyebabnya adalah hipertrigliserida. Hipertrigliseridemia atau tingginya kadar trigliserida darah merupakan salah satu kelainan fraksi lipid yang berhubungan dengan peningkatan resiko penyakit kardiovaskular Penurunan kadar trigliserida dalam darah dapat dilakukan dengan terapi Gemfibrozil. Gemfibrozil adalah regulator lipid plasma yang dapat menurunkan kadar kolesterol total, kolesterol LDL, kolesterol VLDL dan trigliserida serta meningkatkan kolesterol HDL. Penelitian ini bertujuan untuk mengetahui efektivitas gemfibrozil 300 mg terhadap kadar trigliserida pada pasien hipertrigliseridemia di Poliklinik Pratama Negeri Jember (periode Mei-Juli 2020). Jenis penelitian yang digunakan adalah deskriptif observasional dengan metode pendekatan cross sectional. Teknik pengambilan sampel menggunakan total sampling. Pengukuran kadar trigliserida dilakukan pada 60 pasien sebelum dan sesudah menggunakan gemfibrozil 300 mg. Hasil penelitian menunjukkan, persentase penurunan setelah menggunakan gemfibrozil 300 mg terendah sebesar 10,27 ± 8,64% dan tertinggi sebesar  40,40 ± 12,38%. Rata-rata kadar trigliserida sebelum penggunaan gemfibrozil 300 mg sebesar 295,35 ± 35 mg / dl dan rata-rata kadar trigliserida setelah penggunaan gemfibrozil 300 mg adalah 196,75 ± 49,59 mg / dl.
ANTIPLATELET ACTIVITY OF PAPAYA LEAF EXTRACT (Carica papaya L) IN MICE Rosida hari
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 6, No 1 (2023): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v6i1.133

Abstract

Papaya leaves have a number of alkaloid compounds (carpaine, pseudocarpaine, dehydrocarpaine I, dehydrocapaine II and emetine. Carpaine is piperidin alkaloid. The piperidin alkaloid have activity of antiplatelet. This study aims to determine the antiplatelet activity of papaya leaf extract againts male mice. Desain of this research is pure experimental research with pre test – post test control group design. Subjects consisted of 4 groups of mice each group consisted of 5 mice. This study was devided into 4 groups : negative control CMC Na 1%, papaya leaf extract (Carica papaya L) concentration 10%/30g BB, papaya leaf extract (Carica papaya L) 25%/30g BB and papaya leaf extract (Carica papaya L) 50%/30g BB. Method of determined antiplatelet based on parameters using the tail bleeding time. Then the time bleeding was determind on day 0 and day 7. After the percentage increase of bleeding time stastical data were analyzed by one way analysis of variance (ANOVA). The results showed that the yield of papaya leaf extract was 17.6% with 96% ethanol solvent.Research result was found bleeding time with percentage of successive increase in extract papaya leaf 10% (84,33),extract papaya leaf  25% (157,70) and papaya leaf  extract 50% (177,53). The result of data analysis using one way anova showed the difference between bleeding time and the value (sig F=0,000). This result showed a significant difference between treatment groups.
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