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Evi Untoro
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Chemistry Dentistry Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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MUTATION OF STR IN PATERNITY TESTING Djaja Surya Atmadja; Evi Untoro
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 1 (2008): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/10.24843/IJLFS.2008.v01.i01.p05

Abstract

Since the founding of DNA fingerprint by Alec J Jeffreys in 1985, DNA analysis was widely appliedin paternity testing. Nowadays, Short Tandem Repeats (STR) is the most popular DNA typing for paternitytesting because of its high discrimination power, especially when the typing is performed in combination of 6,9, 13 or 15 STR loci. STR is the nuclear DNA, and inherited from the mother and father according toMendelian law. Every child has a pair of DNA fragment, one inherited from the mother (maternal fragment),and the other from the father (paternal fragment). In paternity testing we compare the DNA typing of the childand mother to find the maternal fragment. The other fragment of the child must be the paternal fragment. Thispaternal fragment of the child, then is compared to the fragments of alleged father. The result of thiscomparison is either match (the paternal fragment is the same as one of the alleged father’s DNA fragments)or exclusion (the paternal fragment is not the same with any of the alleged father’s fragments). A child IS thebiological child of alleged father if in every STR locus the comparison is match. A child IS NOT thebiological child of alleged father if in 2 or more STR loci the comparisons are exclusion. Single exclusion in apaternity testing, that still be a single exclusion after additional STR loci analysis is usually caused bymutation. Mutation on STR locus will causes the repeat of a person shift one step more or less than theoriginal. In the case of mutation, the paternity index will decrease although we still confirm that the allegedfather is the biological father of the child. In this paper we report 2 paternity cases that showed mutation inSTR typing.
THE USAGE OF THE VOLUNTARY CADAVER IN EDUCATION OF MEDICINE THROUGH SILENT MENTOR PROGRAM Djaja Surya Atmadja; Evi Untoro
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 2 (2012): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

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Abstract

In the medical education the usage of animals, cadavers or patients for medical training is common practice all over the world. It is widely accepted that the use of human body is better than animal.  The usage of cadavers for training in medical procedures and operations is more acceptable because it causes less harm than practicing directly to the patients. The cadavers for training are usually the unknown persons. Since the source of the unknown cadavers are decreasing from time to time, nowadays some Medical Faculties is looking for alternatives, such as the persons who voluntarily want to donate their bodies for medical education, known as Silent Mentor Program. In this program the live donor candidate (Silent Mentor) writes a will, in which  the donor states that he/she want to donate the body for teaching anatomy, training on medical intervention and surgery, research, organ transplantation or even for museum preparation. This program introduces firstly in Hua Lien, Republic of China (Taiwan) and now has been widely accepted by the community. In Indonesia, Silent Mentor is a new concept. Faculty of Medicine University of Indonesia has begun to adopt this system by sending some lecturers to learn about the Program. An healthy Indonesian male, 60 years old, Moslem, is the first SM candidate in Indonesia. He has signed a will in the front of his lawyer. Now there are about 20 SM candidates, who stated that they want to join Silent Mentor Program, but now is still waiting for preparation the administrative as well as legal procedures. In Indonesia, application of SMP needs some modification, due to differences in the culture, religion, facility and regulation
Co-Authors Djaja Surya Atmadja Djaja Surya Atmadja