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All Journal Sriwijaya Journal of Ophthalmology Ophthalmologica Indonesiana Ophthalmologica Indonesiana
Ibrahim
Department Of Ophthalmology, Faculty Of Medicine, Sriwijaya University Mohammad Hoesin Palembang, South Sumatera
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Physics Public Health

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Characteristics of Malignant Eyelid Basal Cell Carcinoma in Dr. Mohammad Hoesin General Hospital: A Retrospective Study Mutia Arnisa Putri; Ibrahim
Sriwijaya Journal of Ophthalmology Vol. 5 No. 1 (2022): Sriwijaya Journal of Ophthalmology
Publisher : Department of Opthalmology, Faculty of Medicine, Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjo.v5i1.73

Abstract

Introduction: Incidence rates of skin cancer have risen significantly over the last two decades. Most tumors develop in sun-exposed areas of the head and neck. Basal cell carcinoma (BCC) rarely metastasizes but can cause significant morbidity and death due to direct spread to the orbit, head, and neck and frequent recurrence. In addition, approximately 40% of BCC patients have other lesions after 5 years. Although there has been a lot of epidemiological data regarding the characteristics of BCC in developed countries, reports of BCC in Asia, especially in Southern Sumatra, are still at a minimum rate. Methods: This study retrospectively reviewed the medical records specific to periocular BCC. Data were collected from the patient register book recorded from January 2021 to May 2022. The clinical characteristics of patients with BCC, such as gender and age, clinicopathological findings of BCC lesions, and BCC management, were reviewed retrospectively. This study aims to determine the epidemiological profile of the malignant eyelid BCC patient, the BCC lesion characteristics, and the management of BCC cases at Mohammad Hoesin General Hospital Palembang. Results: From 16 BCC patients recruited for this study, most of them were 51–60 years old and 71–80 years old, each with 5 patients (31.3%). The female preponderance of 56.3%. Occulus dextra (56.3%), lower eyelid (62.5%), T1 (87.5%), nodular BCC (75,0%), and primary lesion (75,0%) were the most side, periocular site, size, histopathological subtype and recurrence, respectively. Most therapy done is excision (93,8%), while the leading reconstructive technique was Tenzel’s flap (50,0%). Conclusion: There is a slight preponderance of females as BCC patients. BCC is commonly found in elderly people. The lower eyelid and right side are the most frequent anatomical locations. Nodular is the most common histological subtype. In addition, lesions often present in T1 size and primary lesions. Lastly, the treatment is mainly surgical (excision), with Tenzel's flap as the most used reconstruction technique option.
Identification of A1286C Methylenetetrahydrofolate Reductase Gene Polymorphism in Orbital Region Basal Cell Carcinoma Patients Anisah Khairunnisa; Ibrahim Ibrahim
Majalah Oftalmologi Indonesia Vol 41 No 2 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.722 KB) | DOI: 10.35749/journal.v41i2.35

Abstract

Background: The development of basal cell carcinoma (BCC) shows variations among individuals. The risk factor for development of BCC related to environtmental factor especially exposure to ultraviolet radiation and individual factor. The one of internal risk factor contribute to basal cell carcinoma developmental is genetic instability include defects in folic acid synthesis or DNA synthesis. The critical enzim that participate in the process is regulated by Methylenetetrahydrofolate Reductase (MTHFR) gene. Method: This study was descriptive observational with case study involved 10 orbital region basal cell carcinoma. The diagnosis was based on histopathologic examination of the tumor. Genotype frequencies of A1286C polymorphism were studied by Polymerase Chain Reaction (PCR), amplification and restriction fragment length polymorphism analyses using MboII enzyme. Result: In the present study, from 10 subjects we found male was 7 people (70%) and female was 3 people (30%). Majority of subjects have history of having a job in the sunlight. The most commont of the BCC is nodular (80%). There is one subject with recurrent case. Analysis result of A1286C MTHFR gene show wild type in all cases. Conclusion: There’s no A1286C substitution methylenetetrahydrofolate reductase gene were identified. The whole subjects are wild type.Keywords: basal cell carcinoma, orbital region, folic acid, polymorphism, A1286C MTHFR gene, polymerase chain reaction (PCR), wild type
Identification of A1286C Methylenetetrahydrofolate Reductase Gene Polymorphism in Orbital Region Basal Cell Carcinoma Patients Anisah Khairunnisa; Ibrahim Ibrahim
Majalah Oftalmologi Indonesia Vol 41 No 2 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v41i2.35

Abstract

Background: The development of basal cell carcinoma (BCC) shows variations among individuals. The risk factor for development of BCC related to environtmental factor especially exposure to ultraviolet radiation and individual factor. The one of internal risk factor contribute to basal cell carcinoma developmental is genetic instability include defects in folic acid synthesis or DNA synthesis. The critical enzim that participate in the process is regulated by Methylenetetrahydrofolate Reductase (MTHFR) gene. Method: This study was descriptive observational with case study involved 10 orbital region basal cell carcinoma. The diagnosis was based on histopathologic examination of the tumor. Genotype frequencies of A1286C polymorphism were studied by Polymerase Chain Reaction (PCR), amplification and restriction fragment length polymorphism analyses using MboII enzyme. Result: In the present study, from 10 subjects we found male was 7 people (70%) and female was 3 people (30%). Majority of subjects have history of having a job in the sunlight. The most commont of the BCC is nodular (80%). There is one subject with recurrent case. Analysis result of A1286C MTHFR gene show wild type in all cases. Conclusion: There’s no A1286C substitution methylenetetrahydrofolate reductase gene were identified. The whole subjects are wild type.Keywords: basal cell carcinoma, orbital region, folic acid, polymorphism, A1286C MTHFR gene, polymerase chain reaction (PCR), wild type
Co-Authors Anisah Khairunnisa Mutia Arnisa Putri