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All Journal Jurnal Ilmiah Farmasi Jurnal Riset Kimia
Vinny Hosiana
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Chemistry Medicine & Pharmacology

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PENGARUH VIRGIN COCONUT OIL (VCO) DI DALAM BASIS KRIM TERHADAP PENETRASI ZAT AKTIF Henny Lucida; Vinny Hosiana; Vivi Muharmi
Jurnal Ilmiah Farmasi Vol. 4 No. 2 (2007)
Publisher : Universitas Islam Indonesia

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Abstract

ABSTRACTA study on formulation of cream in a base containing Virgin Coconut Oil (VCO) withPiroxicam (1%) as a model has been undertaken. VCO concentration in the cream-base weremade 0 %, 31%, 36% and 41% respectively to determine the influence of VCO concentration on thepenetration profile of the drug. The profil of penetration was determined by using Franz diffusioncell (vertical type) with the mice’s skin and pH 8 phosphate buffer as membrane and mediumrespectively. Concentration of piroxicam released was determined spectrophotometically atwavelength 353.2 nm. Results indicated that the penetration profile of piroxicam from formula 1, 2and 3 followed zero order kinetic with the slope (k) of 0.0171 (r = 0.9913); 0.0217 (r = 0.9869) and0.0217 (r = 0.9939) respectively, while that from formula 4 followed Higuchi equation with the slope(k) of 0,0570 mg/sec2 / 1(r = 0.9853). The highest rate was observed from Formula 4 (VCOconcentration was 41%). Statistical análysis showed that VCO affected the release of piroxicamfrom the formulation significantly (p
KINETIKA PERMEASI KLOTRIMAZOL DARI MATRIKS BASIS KRIM YANG MENGANDUNG VIRGIN COCONUT OIL (VCO) Henny Lucida; Patihul Husni; Vinny Hosiana
Jurnal Riset Kimia Vol. 2 No. 1 (2008): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v2i1.56

Abstract

 ABSTRACT A kinetic study on the release of clotrimazole from a VCO containing creambase has been undertaken. The in-vitro release of the drug was studied by using a modification diffusion cell apparatus. Four formulations of clotrimazole cream were prepared, each contained either VCO or paraffin liquidum in the cream base. The amount of clotrimazole release were determined by UV spectrophotometer. Results showed that release of clotrimazole from all formulations followed Higuchi kinetics, the release rate constant from F1 (containing VCO) was significantly different than that from F1’ (containing paraffin liquidum) (p < 0.05). The rate constant of clotrimazole from F2 (containing VCO); F2’ (containing paraffin liquidum ) and F1 were not significantly different. Virgin coconut oil (VCO) was a potential cream base matrix regarding the release profile of clotrimazole from the matrix. Keywords : clotrimazol, VCO, permeation kinetic
Co-Authors Henny Lucida Patihul Husni Vivi Muharmi