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All Journal Buletin Farmatera ACI (Acta Cardiologia Indonesiana)
Sheila Dhiene Putri
Department Of Cardiology, Faculty Of Medicine, Universitas Muhammadiyah Sumatera Utara
Medicine & Pharmacology

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Journal : Buletin Farmatera

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Statins' Protective Effect For The Prevention Of Atrial Fibrillation Incidence After Coronary Artery Bypass Surgery Sheila Dhiene Putri; Zainal Safri
Buletin Farmatera Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i2.9736

Abstract

Abstract: Atrial fibrillation (AF) after cardiac surgery is associated with an increased risk of complications, length of stay, and cost of care. Recent studies have demonstrated that statins have pleiotropic effects, including anti-inflammatory effects and preventing atrial fibrillation (AF). The objective of this study was to assess the efficacy of preoperative statin therapy in preventing AF after coronary artery bypass grafting (CABG). 53 patients underwent CABG in our hospital from February to August 2018. Patients were randomized into two groups to examine the effect of statins: those with atorvastatin 20 mg/day during the preoperative period (Atorvastatin group, n = 26) and those with rosuvastatin 10 mg/day (Rosuvastatin group, n = 27). The primary end-point is postoperative AF (POAF), with an overall incidence of postoperative AF of 11.3%. Postoperative AF incidence was insignificantly different between the atorvastatin and rosuvastatin groups (7.7% vs. 14.8%; p = 0,669). Our study indicated that atorvastatin had a similar protective effect to rosuvastatin in terms of post-operative AF prevention.Keywords: statin, post-operative AF
Co-Authors A. Afif Siregar Andra, Cut Aryfa Harris Hasan Nizam Akbar Refli Hasan Zainal Safri