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All Journal Indonesian Journal of Cancer Chemoprevention Medika Tadulako INDONESIAN JOURNAL OF PHARMACY
Agung Eru Wibowo
Pusat Teknologi Farmasi dan Medika - BPPT
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Influence of DMBA (7,12-dimethylbenz-[a]anthracene) Regimen In The Development of Mammae Carcinogénesis on Sprague Dawley Female Rat Wibowo, Agung Eru; Sriningsih, .; Wuyung, Puspita Eka; Ranasasmita, Raafqi
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Research Gateway

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Abstract

There are many methods for development  of mammae cancer animal model, one of which is chemical induction using carcinogenic  agent, DMBA. This research aimed to explore the influence of dose and time regimens of DMBA on development of mammae carcinogenesis on Sprague dawley female rats. The first study was 50 rats treated with 20 mg/kg bw of DMBA orally for eleven times at twice a week. Morphological evaluations were conducted with mammae palpation for 15 weeks and then all of  rats were sacrificed for collecting mammae organs for histological analysis using hematoxylin-eosin staining. The results showed that the first and the latest nodules appeared at the fourth-week and the fourteenth-week after ending DMBA induction, respectively, in which the  most often nodule appearances were at the seventh-week. The number of nodule incidence and multiplicity were by 74% and 2 noduls/rat, respectively. Histological analysis of mammae glands determined that they fell under in Ductal Carcinoma Invasive (DCIV) category. The second study was 25 rats gavaged orally with DMBA at dose 20 mg/kg bw for five times every three days. After palpating for 15 weeks, the results showed that no nodule was observed but the histological analysis demonstrated developing of mammae gland carcinogenesis reaching about 60%  Ductal Carcinoma Insitu (DCIS) and 40% Ductal Carcinoma Invasive (DCIV) stages. Based on the results of this study can be concluded that the dose and frequency of DMBA will affect the successful development of mammary gland carcinogenesis. In DMBA induction with low frequency, no data showed the incidence and multiplicity of tumor, but histopathologic level  carcinogenesis can be distinguished. In DMBA induction with high frequency, incidence and multiplicity of tumor data can be obtained but can not be distinguished histopathologically.
QSAR Analysis of Rocaglamide Derivatives Cytotoxic Activities Using LFER Hansch Model Firdayani, .; Kusumaningrum, Susi; Setyo Utomo, Doddy Irawan; Wibowo, Agung Eru; Chaidir, .
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Research Gateway

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Rocaglamide derivatives are the compounds which have featuring cyclopenta[b]tetra-hydrobenzofuran skeleton. Until now it includes more than 50 naturally occurring derivatives. They were chosen to be interesting candidates for possible therapeutic agents primarily in the field of cancer chemotherapy due to their cytotoxic activities data against various cancer cells. A quantitative structure activity relationship (QSAR) studies were done to investigate physicochemical properties of molecule which  contribute to their activities. Series of rocaglamide derivatives have been used and analyzed using linear free energy regression Hansch model for their cytotoxic activities against MONO-MAC-6 leukemia cells, RAJI lymphoma cells and MEL-JUSO melanoma cells. Results showed that the best QSAR equations were revealed involving C Log P and CMR parameters with nonlinear regression relationships in cytotoxic activities of rocaglamide derivatives against cancer cells above.
Isolation and structure elucidation of main compound originated from sponge Axynissa aplysinoides Sumaryono, Wahono; Wibowo, Agung Eru; ., Chaidir
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.647 KB) | DOI: 10.14499/indonesianjpharm0iss0pp186-191

Abstract

Isolation of the main compound of sponge Axynissa aplysinoides collected from Lombok seawater, has been conducted. Methanol extract of dried sponge was fractionated into nonpolar, semipolar and polar fractions using hexane, ethyl acetate and buthanol. Identification and final purification of the main compound was done using column chromatography and high performance liquid chromatography (HPLC). Structure elucidation of the main compound was performed using mass spectrometry (EIMS), 1H- and 13C-NMR spectroscopies. The main compound was identified as (E)-(4-hydroxystyryl) trimethylammonium.Key words : isolation, structure elucidation, Axynissa aplysinoides
UJI AKTIVITAS SEDIAAN HAIR TONIC KOMBINASI EKSTRAK DAUN PARE (Momordica charantia) DAN EKSTRAK WORTEL (Daucus carota L.) PADA KELINCI JANTAN NEW ZEALAND WHITE Hendriani, Ines Nur; Tamat, Swasono R; Wibowo, Agung Eru
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan Vol 6, No 2 (2019)
Publisher : Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran dan Ilmu Kesehatan

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ABSTRACTA research about hair fertilizer test has been done by using a combination of bitter melon leaf and carrot extracts. Bitter melon leaf (Momordica charantia) is known for having hair nutritive activity, and carrot (Daucus carota L.) is also known for containing vitamin A to nourish the hair scalp. In this research, 3 months old New Zaeland white male rabbit with 2 kg of weight was tested to find out the hair growth activity of single extract and the combination of bitter melon leaf extract (EDP) and Carrot Extract (EW) with a ratio of 1EDP:1EW ; 3EDP:1EW; 3EDP:2EW. The growth and weights of hair that has been smeared on the rabbit's back were observed for 28 days. The results on combination extract with 3EDP: 1EW showed the best result with an average growth of 5.23 mm per week and a weight of 53.44 mg. The result of continued activity test of hair tonic with  concentration of 1%; 2% and 3% showed that hair tonic with 3% concentration had the best activity that is 11.56 mm for the average of hair growth and 51.16 mg for its weight. The result of physicochemical analysis and irritation showed that the color of hair tonic had brown, aromatic, clear, homogeneous, had a specific gravity of 0.9419 and had not causes irritation. Keywords : Hair Tonic Formula, Growth Activity,   Bitter Melon Leaf Extract,   Carrot Extract, Rabbit, Irritation. ABSTRAK Telah dilakukan penelitian pengujian penyubur rambut dari  kombinasi ekstrak daun pare dan wortel. Daun pare (Momordica charantia ) diketahui memiliki aktivitas sebagai penyubur rambut, dan wortel (Daucus carota L .) mengandung vitamin A untuk menutrisi kulit kepala rambut. Dalam penelitian ini dilakukan pengujian pada kelinci jantan New Zealand White berumur 3 bulan dengan bobot 2kg untuk mengetahui aktivitas penumbuh rambut ekstrak tunggal dan  kombinasi dari Ekstrak Daun Pare (EDP) dan Ekstrak Wortel (EW) dengan perbandingan 1EDP:1EW; 3EDP:1EW; 3EDP:2EW. Pertumbuhan rambut dan bobot rambut yang telah diolesi pada punggung kelinci diamati selama 28 hari. Hasil uji pada  kombinasi ekstrak, perbandingan  3EDP:1EW menunjukkan hasil terbaik dengan rata-rata pertumbuhan 5.23 mm perminggu dan bobot 53.44 mg. Hasil uji aktivitas lanjutan sediaan hair tonic dengan konsentrasi 1%; 2% dan 3%, menunjukkan bahwa sediaan hair tonic dengan konsentrasi 3% memiliki aktivitas paling baik yaitu rata-rata panjang rambut 11.56 mm rambut dan bobot rambut 51.16 mg. Hasil uji analisis fisikokimia dan uji iritasi menunjukkan bahwa sediaan hair tonic berwarna coklat, bau aromatik, jernih, homogen, memiliki berat jenis 0,9419 dan tidak menimbulkan iritasi.Kata kunci : Formula Hair Tonic,  Aktivitas Penyubur Rambut,   Daun Pare,   Wortel,  Kelinci, Iritasi
Co-Authors . Chaidir . Firdayani . Sriningsih Chaidir ., Chaidir Doddy Irawan Setyo Utomo Frans Suyatna Hendriani, Ines Nur Nuryati Chaerani Siregar Puspita Eka Wuyung Raafqi Ranasasmita Susi Kusumaningrum Swasono R Tamat Wahono Sumaryono