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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya TRANSIENT Majalah Kesehatan FKUB Jurnal Genta
Satrio Wibowo
Jurusan Teknik Elektro, Universitas Diponegoro Semarang Jl. Prof. Sudharto, SH, Kampus UNDIP Tembalang, Semarang 50275, Indonesia
Agriculture, Biological Sciences & Forestry Education Environmental Science Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Jurnal Kedokteran Brawijaya

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TNF-α AND INTERLEUKIN-6 LEVELS IN CLINICAL EARLY ONSET NEONATAL SEPSIS TOWARD ACUTE LIVER INJURY Dinarshanty, Diani; AS, Noorhamdani; Kawuryan, Siti Lintang; Wibowo, Satrio
Jurnal Kedokteran Brawijaya Vol 29, No. 3 (2017)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2017.029.03.6

Abstract

TNF-? and IL-6 level have an important role in acute liver injury during early onset neonatal sepsis. This study aims to investigate the correlation of TNF-? and IL-6 levels in neonates with clinical early onset neonatal sepsis toward the occurrence of acute liver injury 44 neonates with clinical early onset neonatal sepsis based on SIRS criteria and Rodwell hematologic scored ?3 were included in this study. Acute liver injury is defined as elevated of AST, ALT, or AST: ALT ratio <1. TNF-? and IL-6 levels were measured using ELISA methods. This study showed that TNF-? correlated significantly with AST level (p<0,001, r=0,570), ALT level (p<0,001, r=0,554), and AST: ALT ratio (p<0,001, r=0,652). This study also showed that IL-6 correlated significantly with AST level (p<0,001, r=0,523), ALT level (p<0,001, r=0,482), AST: ALT ratio (p<0,001, r=0,603). Regression test using backward methods showed that TNF-? influence acute liver injury (indicated by AST, ALT, and AST: ALT ratio) more than IL-6. We concluded that TNF-? and IL-6 level in clinical early onset neonatal sepsis correlated with acute liver injury, whereas early onset neonatal sepsis was correlated with acute liver injury.Keywords: Acute liver injury, clinical early neonatal sepsis, IL-6 level, TNF-? level
Co-Authors Arisanti, Ditya Dinarshanty, Diani Mochammad Facta Naila, Centaura Noorhamdani AS Nugroho, Agung Primawardani, Putri Siti Lintang Kawuryan Wisnu Barlianto