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All Journal The Indonesian Biomedical Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Medika Teknika : Jurnal Teknik Elektromedik Indonesia Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia
Hariyono Winarto
Faculty Of Medicine Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital Jakarta
Biochemistry, Genetics & Molecular Biology Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : The Indonesian Biomedical Journal

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Plasma MicroRNA-200c as A Prognostic Biomarker for Epithelial Ovarian Cancer Addin Trirahmanto; Hariyono Winarto; Aria Kekalih; Ferry Sandra
The Indonesian Biomedical Journal Vol 11, No 3 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i3.761

Abstract

BACKGROUND: Ovarian cancer is the 8th most prevalent cancer in women in the world. Current biomarker prognosis for ovarian cancer has numerous limitations, thus new biomarkers are needed. MicroRNAs (miRs) are considered as potential biomarkers in ovarian cancer as they are stable in blood. One candidate is miR-200c, the main regulator in epithelial transition to the mesenchyme. The aim of this study is to determine the role of miR-200c as prognostic biomarker for epithelial ovarian cancer (EOC).METHODS: This is a prospective cohort study conducted at Dr. Sardjito Central General Hospital in Yogyakarta from September 2015 to July 2018. Sampling was done using consecutive sampling method. Forty plasma samples of EOC subjects were included in this study. miR-200c expression was quantified using Reverse Transcriptase Quantitative Quantitative Polymerase Chain Reaction (RTqPCR) with miR-16 as the reference gene.RESULTS: The expression of miR-200c was significantly higher in the group of subjects with preoperative CA-125 levels >500 U/mL (p=0.009) than the group of subjects with preoperative CA-125 levels <500 U/mL. Subjects with higher miR-200c expression had lower survival rate than subjects with lower miR-200c expression, although not statistically significant.CONCLUSION: The miR-200c could be a promising biomarker for EOC. Further studies with larger sample sizes are needed to clarify the prognostic value of miR200c.KEYWORDS: miR-200c, epithelial ovarian cancer, prognosis, overall survival
Co-Authors Addin Trirahmanto Affi Angelia Ratnasari Amalia, Gassani Andrijono Andrijono Andrijono Andrijono Andrijono Antonius, Puja Agung Aria Kekalih Bambang Sutrisna Bambang Sutrisna Bambang Sutrisna Bambang Sutrisna Bambang Sutrisna Bismarck J. Laihad Budiningsih Siregar Budiningsih Siregar Daud, Sulaeman Ediwibowo Ambari Ediwibowo Ambari Eka R Gunardi Erwin Rahakbauw Ferry Sandra Fitriyadi Kusuma Gatot Purwoto Heru Prasetyo Indra, Ken Jamhari Jamhari Kartiwa H Nuryanto Kartiwa Hadi Nuryanto Kemal Akbar Suryoadji Ken Indra Laila Nuranna Laila Nuranna Markus, Unedo H Markus, Unedo H Maulana, Muhammad Sobri Michael Adrian Muhammad Haekal Nana Supriana Nana Supriana Nuryanto, Kartiwa H Rahakbauw, Erwin Sigit Purbadi Sri M. Sekarutami Sulaeman Daud Tofan Widya Utami Tricia Dewi Anggraeni Unedo H Markus William Halim