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All Journal Health and Medical Journal Andalas obstetrics and gynecology journal Jurnal Health Sains Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Antonius, Puja Agung
Andalas University
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC): a case report and review Puja Agung Antonius; Hariyono Winarto
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1292.711 KB) | DOI: 10.25077/jikesi.v2i1.528

Abstract

Objective: Improving skill and knowledge to diagnose and manage a rare case of small cell neuroendocrine uterine cervical cancer Method: a Case report Result: A 51 years old, para 2, Indonesian woman with chief complaint post-coital vaginal bleeding. Gynecology examination revealed cervical exophytic fragile mass size 3x3x3,5 cm, easily bleeding, with a necrotic part, infiltrated both parametria but not reach the pelvic wall correspond to stage IIB. Initially, the histopathology result from punch biopsy was an adenocarcinoma well-differentiated, with no lymph vascular invasion, DD/ adenosquamous, neuroendocrine tumor. We did the histopathology review continued with immunohistochemistry examination. Immunohistochemistry result showed that although all the sample was not typical, immunohistochemical outward patterns can support morphological features of high-grade neuroendocrine carcinoma, small cell type. We proceed here for chemoradiation therapy. Conclusion: Small cell neuroendocrine carcinoma of the uterine cervix is a rare case. Histopathology and immunohistochemistry examination has an important role to develop the diagnosis. Although the prognosis is poor, adjuvant chemotherapy or chemoradiation was associated with improved survival in patients with advance staged. Keywords: SCNEC, immunohistochemistry, chemoradiation
Ovarian goiter with papillary thyroid carcinoma: A very rare case Puja Agung Antonius; Dr. dr. Syamel Muhammad, SpOG(K)-Onkogin; Muhammad Zaldy Rasyid Putra; Santy Saberko
Andalas Obstetrics And Gynecology Journal Vol. 6 No. 2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.179-183.2022

Abstract

Struma ovarii is a rare condition, in which thyroid tissue is the predominant element in an ovarian carcinoma. Thyroid tissue may demonstrate the same spectrum of pathological features as in the normal thyroid including benign and malignant changes. The malignant type is very rare, only 5% from all incidents of goiter ovarii. We present a case of papillary thyroid carcinoma arising in a struma ovarii of the right ovary in a 43-year-old female
Profil Kasus pada Ibu Hamil yang Dirawat dengan Covid-19 di RSUP Dr. M. Djamil Padang Periode Januari—Desember 2020 Salsabila Dhiyaa Syifa; Mohamad Reza; Zelly Dia Rofinda; Puja Agung Antonius; Firdawati Firdawati; Biomechy Oktomalio Putri
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 3 (2022): September 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i3.888

Abstract

Latar Belakang: Coronavirus Disease 2019 (COVID-19) adalah penyakit pada saluran pernafasan yang diakibatkan oleh Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Virus ini dapat menginfeksi kelompok rentan, termasuk ibu hamil. Penelitian ini bertujuan untuk mengetahui gambaran profil kasus pada ibu hamil yang dirawat dengan COVID-19. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran profil kasus pada ibu hamil yang dirawat dengan COVID-19 di RSUP Dr. M. Djamil Padang Periode Januari—Desember 2020. Metode: Penelitian ini menggunakan metode deskriptif dengan desain cross-sectional di RSUP Dr. M. Djamil Padang dengan jumlah sampel sebanyak 136 ibu hamil dengan COVID-19 pada tahun 2020. Data yang digunakan berupa data sekunder dari rekam medis dengan menggunakan teknik total sampling. Hasil: Ibu hamil yang terpapar COVID-19 memiliki gejala ringan (95,6%), berada pada usia tidak berisiko (83,8%),berada pada kehamilan trimester III (87,5%), dan terpapar tanpa komorbid (81,6%). Didapatkan juga peningkatan kadar NLR dan D-Dimer, banyak yang mendapat tindakan berupa sectio caesarea (64,7%), dan adanya kematian 3 ibu (2,2%). Kesimpulan: Sebagian besar ibu hamil dengan COVID-19 memiliki gejala ringan, berada pada usia tidak berisiko (usia 20—35 tahun), hamil pada trimester III, terpapar tanpa komorbid, memiliki peningkatan NLR dan D-Dimer, dilakukan tindakan sectio caesarea, dan tidak banyak terjadi kasus kematian.
Myxoid ovaries that resemble malignancy in young girls: a case report Fajriman Fajriman; Puja Agung Antonius; Syammel Muhammad
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.473-478.2023

Abstract

In the most recent publications on Mayer-Rokitansky-Küster-Hauser (MRKH) Myxoma is a benign tumor that generally occurs in the heart, soft tissue, muscle, skin and bone. But in this case, we present myxoma that occurs primarily in the ovary. Ovarian myxsoma is a rare benign tumor.In this case report, it was found that a 12-year-old girl was brought by her parents to the M. Djamil Hospital in the city of Padang, West Sumatra. After performing the gynecological physical examination and ultrasonography, there was a hypoechoic mass with an indeterminate solid part of the right adnexa, which was suspected of being an ovarian malignancy. Then it was decided to carry out a procedure in the form of a conservative surgical staging laparotomy. The results of the Anatomical Pathology examination confirmed the myxoid ovarian appearance and the patient was decided for regular monitoring. 
Choriocarcinoma with Pulmonary and Spinal Metastases : A Case Report Fardani Putra Syafar; Syammel Muhammad; Puja Agung Antonius
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.495-501.2023

Abstract

Background : Choriocarcinoma is extremely malignant tumor contains of anaplastic trophoblast and prominent hemorrhage, necrosis, and vascular invasion. Choriocarcinoma is a rare, aggressive neoplastic type of trophoblastic disease. This condition grow rapidly and can metastasize to the lung and liver. There are few cases of choriocarcinoma metastases to the spine that have been reported.Case Report : A 28-year-old woman with complaints of haemoptoe and shortness of breath. Previously the patient complained of not feeling the sensation for defecation and micturition. The patient had been diagnosed with choriocarcinoma since 3 years ago, refused to have a hysterectomy and had received chemotherapy 12 times in the first year with choriocarcinoma, but dropped out of chemotherapy in the second year, then came with a worsening condition a year later. The results of the chest x-ray and lumbar MRI showed suspicion of metastases to the lungs and spine. The patient was continued with chemotherapy with paclitaxel and carboplatin and was monitored with periodic beta HCG evaluation. Choriocarcinoma a have different prognoses depending on stage and onset. In these patients, based on FIGO staging, she has reached stage IV and also suspected chemotherapy-resistant Gestational Trophoblastic Neoplasia (GTN), worsened by disobedience to previous treatment. Many patients with GTN require multiple regimens with or without surgery to achieve complete remission.
Carcinoma Endometrioid Ovary pada Struma Ovarii Syamel Muhammad; Puja Agung Antonius; Susan Meuthia; Aisha Savannah
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1361

Abstract

Kanker ovarium merupakan penyebab utama kematian pada wanita yang didiagnosis sebagai kanker ginekologi. Tingginya angka kematian akibat kanker ovarium karena mayoritas kasus bersifat asimptomatik dan skrining yang dilakukan untuk menegakkan diagnosis masih kurang. Hal ini menyebabkan kanker ovarium dikenal sebagai silent killer. Etiologi spesifik kanker ovarium hingga belum diketahui dengan pasti, namun teradapat beberapa faktor risiko yang berperan terhadap terjadinya kanker ovarium. Faktor risiko genetik diduga berkaitan erat dengan kejadian kanker ovarium, diantaranya mutasi pada gen TP53, BRCA1 dan BRCA2.  Diagnosis kanker ovarium sulit dilakukan pada stadium dini karena tidak adanya gejala spesifik.  Untuk menegakkan diagnosis kanker ovarium dibutuhkan anamnesis, pemeriksaan fisik dan pemeriksaan penunjang seperti CT scan, USG, pemeriksaan tumor marker dan biopsi. Hingga saat ini, pembedahan masih menjadi penatalaksanaan utama bagi kanker ovarium. Pemeriksaan histopatologi juga perlu dilakukan untuk menentukan keganasan, jenis kanker, dan penentuan staging. Kemoterapi adjuvan diberikan pada pasien setelah pembedahan, kecuali jika penyakit hanya terbatas pada ovarium dan  pada kanker yang tidak bisa dioperasi. Prognosis kanker ovarium bergantung dari jenis kanker, stadium  dan komplikasi yang terjadi. Pada jurnal ini dilaporkan kasus seorang pasien perempuan, berusia 59 tahun dengan carcinoma endometrioid ovary pada struma ovarii.
Personalized Medicine on Muscinous Ovarian Cancer Effendy Fila; Antonius Puja Agung
Jurnal Health Sains Vol. 5 No. 3 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Ovarian cancer (OC), ranking third among gynecological cancers, poses a significant health concern with the worst prognosis and highest mortality rate. The global incidence, as per 2018 data, reached 295,414 cases, constituting 3.4% of women's cancer cases. The prevalence has notably risen in Asian countries, including Singapore and Indonesia. This report highlights two cases from Dr. M. Djamil, emphasizing the importance of personalized medicine (PM) in treating OC. PM, leveraging genomic information, aids in tailoring treatments for individual patients. The standard treatment involves cytoreductive surgical debulking and platinum-based chemotherapy. Notably, PM has shown promise in addressing specific genetic mutations, such as BRCA1 and BRCA2, prevalent in breast and ovarian tumors, enabling more targeted therapeutic approaches and enhancing treatment outcomes.
PERITONEAL TUBERCULOSIS IN YOUNG AGE LADY MIMICKING GYNECOLOGY MALIGNANCY : A CASE REPORT Lusi Jelita Sari; Puja Agung Antonius; Syamel Muhammad
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.653-659.2024

Abstract

Background : Peritoneal tuberculosis is one of the most challenging forms of extrapulmonarytuberculosis to diagnose. Extrapulmonary TB is very difficult to diagnose because of its non-specific signs and symptoms, thus it sometimes leads to a diagnosis of gynaecologicalmalignancy such as advanced ovarian carcinoma.Case Report : A teenage girl, 12 years old, with a chief complaint of intermittent abdominalpain since the last 1 month. There was no history of an enlarged abdomen, fever and weightloss. Ultrasound examination revealed an irregular adnexal mass suggesting an ovarianmalignancy with other possibilities of an infectious process. Diagnostic laparoscopy andperitoneal biopsy were performed on the patient. Intraoperatively, multiple friable nodular-mylar peritoneal masses with abdominopelvic attachments and fibrin fibres and white vesicleswere found on the entire surface of the genitalia, peritoneum, and intestines. A mass biopsywas performed with histopathological results showing peritoneal tuberculosis. Currently, thepatient is undergoing anti-tuberculosis drugs (OAT) treatment.Discussion : The diagnosis of this disease is difficult to establish. Symptoms are highlyvariable and non-specific and can lead to the wrong tumour pathology. The clinicalcharacteristics are dominated by changes in general condition, abdominal pain and transitdisorders, as well as masses (20 to 25%). The gold standard for definitive PTB diagnosisremains laparoscopy with peritoneal biopsy and subsequent pathological or microbiologicalconfirmation. Yellow/white nodules in the peritoneum observed on the patient's laparoscopicimages are the hallmark of wet peritoneal TB. Omental thickening and abdominal cocoon withmatted small bowel are other classic laparoscopic findings for peritoneal TB.Conclusion : PTB has similar characteristics to peritoneal carcinoma, which makes diagnosisdifficult for clinicians. Early and correct diagnosis of PTB helps to initiate medical managementquickly and helps reduce morbidity and mortality.
Co-Authors Aisha Savannah Effendy Fila Fajriman Fajriman Fardani Putra Syafar Firdawati Firdawati Hariyono Winarto Irfan Kurnia Lusi Jelita Sari Mohamad Reza Muhammad Zaldy Rasyid Putra Putri, Biomechy Oktomalio Salsabila Dhiyaa Syifa Santy Saberko Susan Meuthia Syamel Muhammad Syamel Muhammad Syammel Muhammad Syammel Muhammad Zelly Dia Rofinda