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All Journal Health and Medical Journal Andalas obstetrics and gynecology journal Jurnal Ilmu Kesehatan Indonesia
Antonius, Puja Agung
Fakultas Kedokteran Universitas Andalas
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC): a case report and review Puja Agung Antonius; Hariyono Winarto
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1292.711 KB) | DOI: 10.25077/jikesi.v2i1.528

Abstract

Objective: Improving skill and knowledge to diagnose and manage a rare case of small cell neuroendocrine uterine cervical cancer Method: a Case report Result: A 51 years old, para 2, Indonesian woman with chief complaint post-coital vaginal bleeding. Gynecology examination revealed cervical exophytic fragile mass size 3x3x3,5 cm, easily bleeding, with a necrotic part, infiltrated both parametria but not reach the pelvic wall correspond to stage IIB. Initially, the histopathology result from punch biopsy was an adenocarcinoma well-differentiated, with no lymph vascular invasion, DD/ adenosquamous, neuroendocrine tumor. We did the histopathology review continued with immunohistochemistry examination. Immunohistochemistry result showed that although all the sample was not typical, immunohistochemical outward patterns can support morphological features of high-grade neuroendocrine carcinoma, small cell type. We proceed here for chemoradiation therapy. Conclusion: Small cell neuroendocrine carcinoma of the uterine cervix is a rare case. Histopathology and immunohistochemistry examination has an important role to develop the diagnosis. Although the prognosis is poor, adjuvant chemotherapy or chemoradiation was associated with improved survival in patients with advance staged. Keywords: SCNEC, immunohistochemistry, chemoradiation
Ovarian goiter with papillary thyroid carcinoma: A very rare case Puja Agung Antonius; Dr. dr. Syamel Muhammad, SpOG(K)-Onkogin; Muhammad Zaldy Rasyid Putra; Santy Saberko
Andalas Obstetrics And Gynecology Journal Vol 6, No 2 (2022): VOL 6, NO2 (2022)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.6.2.179-183.2022

Abstract

Struma ovarii is a rare condition, in which thyroid tissue is the predominant element in an ovarian carcinoma. Thyroid tissue may demonstrate the same spectrum of pathological features as in the normal thyroid including benign and malignant changes. The malignant type is very rare, only 5% from all incidents of goiter ovarii. We present a case of papillary thyroid carcinoma arising in a struma ovarii of the right ovary in a 43-year-old female
Profil Kasus pada Ibu Hamil yang Dirawat dengan Covid-19 di RSUP Dr. M. Djamil Padang Periode Januari—Desember 2020 Salsabila Dhiyaa Syifa; Mohamad Reza; Zelly Dia Rofinda; Puja Agung Antonius; Firdawati Firdawati; Biomechy Oktomalio Putri
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 3 (2022): September 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i3.888

Abstract

Latar Belakang: Coronavirus Disease 2019 (COVID-19) adalah penyakit pada saluran pernafasan yang diakibatkan oleh Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Virus ini dapat menginfeksi kelompok rentan, termasuk ibu hamil. Penelitian ini bertujuan untuk mengetahui gambaran profil kasus pada ibu hamil yang dirawat dengan COVID-19. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran profil kasus pada ibu hamil yang dirawat dengan COVID-19 di RSUP Dr. M. Djamil Padang Periode Januari—Desember 2020. Metode: Penelitian ini menggunakan metode deskriptif dengan desain cross-sectional di RSUP Dr. M. Djamil Padang dengan jumlah sampel sebanyak 136 ibu hamil dengan COVID-19 pada tahun 2020. Data yang digunakan berupa data sekunder dari rekam medis dengan menggunakan teknik total sampling. Hasil: Ibu hamil yang terpapar COVID-19 memiliki gejala ringan (95,6%), berada pada usia tidak berisiko (83,8%),berada pada kehamilan trimester III (87,5%), dan terpapar tanpa komorbid (81,6%). Didapatkan juga peningkatan kadar NLR dan D-Dimer, banyak yang mendapat tindakan berupa sectio caesarea (64,7%), dan adanya kematian 3 ibu (2,2%). Kesimpulan: Sebagian besar ibu hamil dengan COVID-19 memiliki gejala ringan, berada pada usia tidak berisiko (usia 20—35 tahun), hamil pada trimester III, terpapar tanpa komorbid, memiliki peningkatan NLR dan D-Dimer, dilakukan tindakan sectio caesarea, dan tidak banyak terjadi kasus kematian.
High Grade Appendiceal Mucinous Neoplasma Reviewing Primary Tube Malignancy : A Case Report Irfan Kurnia; Puja Agung Antonius; Syammel Muhammad
Andalas Obstetrics And Gynecology Journal Vol 7, No 2 (2023): VOL 7, NO 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.467-472.2023

Abstract

Appendiceal mucinous neoplasms (AMNs) are rare tumors accounting for less than 1% of all cancers. The clinical presentations of AMN vary significantly and the diagnosis of most patients is during surgery for suspected appendicitis, peritonitis or gynecological cancer. There were many case reports AMN mimicking an ovarian cancer. In this case, we reported a 64-year postmenopause woman with diagnosed peritonum carcinomatosis dd/ ovarian cancer and it actually AMN in RSUP dr. M. Djamil Padang, West Sumatera. The diagnosis is estimated by ultrasonography (USG), computed tomography (CT), magnetic resonance imaging (MRI) and diagnostic laparoscopy followed by histopathologic verification. The evaluation of the prognosis of appendix mucinous adenocarcinoma mainly depends on whether the tumour is in an advanced stage, the degree of malignancy, and whether an AMN is formed
Myxoid ovaries that resemble malignancy in young girls: a case report Fajriman Fajriman; Puja Agung Antonius; Syammel Muhammad
Andalas Obstetrics And Gynecology Journal Vol 7, No 2 (2023): VOL 7, NO 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.473-478.2023

Abstract

In the most recent publications on Mayer-Rokitansky-Küster-Hauser (MRKH) Myxoma is a benign tumor that generally occurs in the heart, soft tissue, muscle, skin and bone. But in this case, we present myxoma that occurs primarily in the ovary. Ovarian myxsoma is a rare benign tumor.In this case report, it was found that a 12-year-old girl was brought by her parents to the M. Djamil Hospital in the city of Padang, West Sumatra. After performing the gynecological physical examination and ultrasonography, there was a hypoechoic mass with an indeterminate solid part of the right adnexa, which was suspected of being an ovarian malignancy. Then it was decided to carry out a procedure in the form of a conservative surgical staging laparotomy. The results of the Anatomical Pathology examination confirmed the myxoid ovarian appearance and the patient was decided for regular monitoring. 
Choriocarcinoma with Pulmonary and Spinal Metastases : A Case Report Fardani Putra Syafar; Syammel Muhammad; Puja Agung Antonius
Andalas Obstetrics And Gynecology Journal Vol 7, No 2 (2023): VOL 7, NO 2 (2023)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.2.495-501.2023

Abstract

Background : Choriocarcinoma is extremely malignant tumor contains of anaplastic trophoblast and prominent hemorrhage, necrosis, and vascular invasion. Choriocarcinoma is a rare, aggressive neoplastic type of trophoblastic disease. This condition grow rapidly and can metastasize to the lung and liver. There are few cases of choriocarcinoma metastases to the spine that have been reported.Case Report : A 28-year-old woman with complaints of haemoptoe and shortness of breath. Previously the patient complained of not feeling the sensation for defecation and micturition. The patient had been diagnosed with choriocarcinoma since 3 years ago, refused to have a hysterectomy and had received chemotherapy 12 times in the first year with choriocarcinoma, but dropped out of chemotherapy in the second year, then came with a worsening condition a year later. The results of the chest x-ray and lumbar MRI showed suspicion of metastases to the lungs and spine. The patient was continued with chemotherapy with paclitaxel and carboplatin and was monitored with periodic beta HCG evaluation. Choriocarcinoma a have different prognoses depending on stage and onset. In these patients, based on FIGO staging, she has reached stage IV and also suspected chemotherapy-resistant Gestational Trophoblastic Neoplasia (GTN), worsened by disobedience to previous treatment. Many patients with GTN require multiple regimens with or without surgery to achieve complete remission.
Carcinoma Endometrioid Ovary pada Struma Ovarii Syamel Muhammad; Puja Agung Antonius; Susan Meuthia; Aisha Savannah
Health and Medical Journal Vol 5, No 3 (2023): HEME September 2023
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v5i3.1361

Abstract

Kanker ovarium merupakan penyebab utama kematian pada wanita yang didiagnosis sebagai kanker ginekologi. Tingginya angka kematian akibat kanker ovarium karena mayoritas kasus bersifat asimptomatik dan skrining yang dilakukan untuk menegakkan diagnosis masih kurang. Hal ini menyebabkan kanker ovarium dikenal sebagai silent killer. Etiologi spesifik kanker ovarium hingga belum diketahui dengan pasti, namun teradapat beberapa faktor risiko yang berperan terhadap terjadinya kanker ovarium. Faktor risiko genetik diduga berkaitan erat dengan kejadian kanker ovarium, diantaranya mutasi pada gen TP53, BRCA1 dan BRCA2.  Diagnosis kanker ovarium sulit dilakukan pada stadium dini karena tidak adanya gejala spesifik.  Untuk menegakkan diagnosis kanker ovarium dibutuhkan anamnesis, pemeriksaan fisik dan pemeriksaan penunjang seperti CT scan, USG, pemeriksaan tumor marker dan biopsi. Hingga saat ini, pembedahan masih menjadi penatalaksanaan utama bagi kanker ovarium. Pemeriksaan histopatologi juga perlu dilakukan untuk menentukan keganasan, jenis kanker, dan penentuan staging. Kemoterapi adjuvan diberikan pada pasien setelah pembedahan, kecuali jika penyakit hanya terbatas pada ovarium dan  pada kanker yang tidak bisa dioperasi. Prognosis kanker ovarium bergantung dari jenis kanker, stadium  dan komplikasi yang terjadi. Pada jurnal ini dilaporkan kasus seorang pasien perempuan, berusia 59 tahun dengan carcinoma endometrioid ovary pada struma ovarii.
Co-Authors Aisha Savannah Fajriman Fajriman Fardani Putra Syafar Firdawati Firdawati Hariyono Winarto Irfan Kurnia Mohamad Reza Muhammad Zaldy Rasyid Putra Putri, Biomechy Oktomalio Salsabila Dhiyaa Syifa Santy Saberko Susan Meuthia Syamel Muhammad Syammel Muhammad Syammel Muhammad Zelly Dia Rofinda