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Dina Rahayu
Program Studi Farmasi,Fakultas Farmasi,Universitas Indonesia Timur Makassar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Uji Efektivitas Antidiabetik Kombinasi Ekstrak Daun Senggani (Melastomapolyanthum .Bl) dan Glibenklamid dalam Menurunkan Kadar Glukosa Darah pada Mencit (Mus Musculus): Antidiabetic Effectiveness Test of A Combination of Senggani (Melastoma Polyanthum .Bl) and Glibenclamide Leaf Extract in Reducing Blood Glucose Levels in Mice (Mus Musculus) Sry Widyastuti; Samsidar Usman; Dina Rahayu
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 3 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.66 KB) | DOI: 10.25026/jsk.v4i3.1028

Abstract

This study aims to determine the antidiabetic effectiveness of the combination of Senggani leaf extract (Malestoma polyanthum Bl.) And Glibenclamide against alloxan-induced mice. This study used 15 male mice divided into 5 groups and each group consisted of 3 male mice, group I was given Na.CMC 1% w / v, groups III, IV, V were each given a combination of senggani leaf extract 90 mg / kg, 180 mg / kg, 360 mg / kg and 5 mg of glibeclamide as the treatment group, and for group II were given glibenclamide suspension 5 mg for comparison. Alloxan 150 mg / KgBW was used as an inducer of diabetes. Measurement of blood glucose levels was carried out three times, namely initial glucose measurement, post-induction glucose measurement and post-treatment glucose measurement. The results showed that giving senggani leaf extract with a concentration of 90 mg / kg BW, 180 mg / kg BW, 360 mg / kg BW had an antidiabetic effect in male mice. Senggani leaf extract 360 mg / kg BW showed the most effective antidiabetic effect, but still more smaller than the 5 mg glibenclamide suspension.
Co-Authors Samsidar Usman Sry Widyastuti