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PREVALENCE OF NASOPHARYNGEAL CARCINOMA PATIENTS IN DEPARTEMENT OF ORL-HNS HASAN SADIKIN GENERAL HOSPITAL 2010 -2017 Riri Handayani; Yussy Afriani Dewi; Deasy Z Madani
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 01 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i01.3191

Introduction: Nasopharingeal Carcinoma starting from Rosenmuller fossa and intracranial or local spread as a mass in the head area. Nasopharyngeal carcinoma is also associated with hearing problems, serous otitis media, tinnitus, nasal congestion, anosmia, nose bleeding, difficulty swallowing, and dysphonia. Nasopharyngeal carcinoma is a disease that spreads globally and divides races around the world. The purpose of this study is to determine the prevalence of nasopharyngeal disease in Otorhinolaringology-Head and Neck Department, Dr. Hasan Sadikin General Hospital Bandung in 2010-2017. Methods: Medical record method description of Nasopharyngeal Carcinoma at Departement of Otorhinolaringology- Head and Neck Surgery, Dr. Hasan Sadikin General Hospital Bandung in 2010-2017 that used sampling method. Results: There were 1378 patients nasopharyngeal carcinoma, 976 people that included, 657 were men and 319 were women. Obtain most elementary school education (54.9 %) the majority of male patients (67.3 %) with various job background, whereas female patients were housewives (28.1%), and those aged 41-50 years (34%). Most histopathology are undifferentiated carcinoma (58.3 %). Conclusion: Nasopharyngeal Carcinoma patients at the Otorhinolaringology-Head and Neck Surgery Departement. Dr. Hasan Sadikin General Hospital Bandung are 1378 cases. There was higher instance in middle age, and older men and elementary school educated with major histopathology finding was undifferentiated carcinoma

CHARACTERISTICS OF RECURRENCE NASOPHARYNGEAL CARCINOMA IN HASAN SADIKIN HOSPITAL PERIOD 2017-2019 Mohammad Adithya Prawiranata; Yussy Afriani Dewi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i02.3843

Abstract Introduction: Nasopharyngeal carcinoma is a malignancy that occurs in the squamous epithelium in the nasopharynx region. Recurrent Nasopharyngeal carcinoma is defined as tumor recurrence after the complete remission. Patients with recurrent NPC always experience local, regional, or both failure, with or without distant metastases and can damage surrounding tissue.. Methods: This research method was a retrospective descriptive based on medical record data in patients with recurrent nasopharyngeal carcinoma at ORL-HNS outpatient ward subdivision of Head Neck Surgery, RSHS, Bandung from 2017 to 2019. Result: In RSHS Bandung, there was 1727 patient NPC period 2017-2019. There was 135 recurrent nasopharyngeal carcinoma patients (7,8 %) consist of 96 male and 39 female, aged over 40 years as many as 107 patients. More patients were found in T3-T4 (56%), N2-N3(56%), M0 (91%), stage III-IV (75%). The duration of the patient experienced a relapse after initial therapy for more than 24 months (52%). Conclusion: Characteristics of recurrent nasopharyngeal carcinoma most of them come with stage III-IV, T3-T4 without distant metastases, with a recurrence within less than 24 months. There was 7,8% recurrent nasopharyngeal carcinoma patients Keywords: Charactherisic, Nasopharyngeal Carcinoma, Recurrence

CORRELATION BETWEEN S100 PROTEIN EXPRESSION WITH CLINICAL STAGING NASOPHARYNGEAL CARCINOMA TYPE III Ismi Cahyadi; Yussy Afriani Dewi; Nur Akbar Aroeman
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i02.3898

Abstract Introduction: Nasopharyngeal carcinoma is the most found head and neck cancer, which originated from a nasopharyngeal epithelial cell, and predilection site commonly at rosen muller fossa. S100 protein inflammatory mediators are involved in the regulation of cellular processes including inflammation and malignancy. S100 protein plays a central role in the proliferation, regulation of cell apoptosis and metastasis causing continuing growth of cancer cells through activation of STAT3 by IL-6, NF-κB, ROS. Objective: This study aimed to determine the correlation between S100 protein expression levels to the clinical stage of NPC WHO type III. Method: This research is a cross-sectional analytic study. This study was held in the Anatomical Pathology Department of Hasan Sadikin Hospital from August until October 2015. The study was conducted using 29 pieces of secondary data, medical records and paraffin blocks anatomical pathology of NPC patients were examined S100 protein immunohistochemistry. Result: This study was performed from 29 subjects (18 males and 9 females). There was a strong positive correlation between histoscore S100 protein expression with clinical staging p<0.05. There is a significant correlation between S100 protein expression with the clinical stage of NPC WHO type III using double regression analysis (F=15.676, p=0.000). Conclusion: There were significant correlation S100 protein expression levels to clinical stage nasopharyngeal carcinoma WHO type III.

EFFECT OF SEA CUCUMBER OIL AND HONEY IN POST RADIOTHERAPY NASOPHARYNGEAL CARCINOMA PATIENTS Wawan Hendrawan; Bogi Soeseno; Tonny Basriyadi S; Yussy Afriani Dewi; Ade Burhanuddin
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i02.3899

Abstract Introduction: Nasopharyngeal carcinoma is one of the most commonly found cases of head and neck malignancy. The most common side effects of radiotherapy is skin damaged. Until now, there is no standard therapy that has been given to post radiotherapy patient in Hasan Sadikin Hospital. Sea cucumber and honey can accelerate the healing process of the wound caused by radiotherapy. Objective: This study was conducted to compare the effects of the use topical sea cucumber oil and honey in patient with nasopharyngeal carcinoma post radiotherapy. Method: The study was conducted at Radiotherapy Clinic in Hasan Sadikin Hospital from may until September 2015 with patients who experienced skin damaged level two or more based on the criteria of Radiation Therapy Oncology Group (RTOG). This was an experimental study. Subjects were selected consecutively between the two groups: sea cucumber oil group and honey group. The draft analysis was done using Randomized Controlled Trial (RCT). Result: 30 patients were divided equally into two groups, sea cucumber group and honey group. Most of the nasopharyngeal carcinoma patients were >45 years old, the ratio man to woman was 2-3:1, with the BMI was <18.5. All subjects in this study experienced recovery rate up to level 1 (p=1.0), after one week of treatment. In the 2nd week after treatment all patients in the sea cucumber group achieved recovery up to level 0, and in the honey group as much as 2 patients only experienced the recovery rate to level 0, while the remaining 13 subjects remained at level 1 (p=0.0001). It was found that the wound healing process occurs better in sea cucumber oil group than the honey group (p=0.0001). Conclusion: Sea cucumber oil accelerates the healing process of the skin tissue damaged in patients with nasopharyngeal carcinoma after radiotherapy, faster than with honey.

Side Effects of Neoadjuvant Chemotherapy for Nasopharyngeal Carcinoma Genggam Jagad Agami; Yussy Afriani Dewi; Ongka Muhammad Saifuddin
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 03 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i03.4332

Introduction: Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma of the mucosal nasopharynx with a unique geographical distribution which particularly prevalent in the east and southeast Asia. While nasopharyngeal carcinoma is a highly radiosensitive tumor, chemotherapy is added to enhance the effect of treatment. The therapeutic side effect is one of many factors that need to be considered when choosing the treatment method. Therefore, this study is conducted to address the side effect of neoadjuvant chemotherapy. Objective: This study is conducted to address the side effect of neoadjuvant chemotherapy. Methods: This study was a retrospective cohort study with total sampling method of all NPC patients in Hasan Sadikin General Hospital 2015-2019 period. Results: From a total of 247 subjects, NPC occurred in 180 men (72.87%). The most widely used regimen was Cisplatin + 5FU which is used in 187 patients (75.70%). There were several side effects caused by NPC chemotherapy including vomiting, nausea, fatigue, weight loss, dermatitis, stomatitis, hepatotoxicity, ototoxic, diarrhea, leucopenia, neutropenia, thrombocytopenia, and anemia. Conclusion: The most common side effect of cisplatin+5FU were ototoxicity therefore, audiometric examination both before and after administration of chemotherapy. Laboratory examination was needed for the administration of carboplatin+paclitaxel to monitor the side effects of neutropenia.

Association between Mosquito Coils Use with Nasopharyngeal Carcinoma Witri Septiani; Yussy Afriani Dewi; Irvan Afriandi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 03 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i03.4381

Introduction: Nasopharyngeal carcinoma (NPC) is a malignancy of squamous cells on the nasopharyngeal epithelial layer and is the most common otorhinolaryngology malignancy found in Indonesia. The etiology of NPC is multifactorial, including food, environment, genetics, and Epstein-Barr virus infection. Mosquito coils contain volatile carcinogens, such as formaldehyde and acetaldehyde, which may cause malignancy on upper respiratory tract epithelial cells. Objectives: The study aimed to understand the association between mosquito coils use with the incidence of nasopharyngeal carcinoma. Methods: This was a hospital-based unmatched case-control study design involving 80 patients on the Oncology Clinic of Department of Otorhinolaryngology-Head and Neck Surgery at Dr. Hasan Sadikin General Hospital from September to October 2015. The questionnaire about NPC risk factor exposure, including the history of mosquito coil use, was applied as a study instrument. Statistical analysis used the chi-square test to acquire the association between two categorical variables and was considered significant if P-value is <0.05. Results: The percentage of mosquito coil users in the case group (52.7%) was higher than in the control group (30%). Statistical analysis using the chi-square test revealed P = 0.041 with OR (CI 95%) equals 2.58 (1.03-6.45). This result showed that mosquito coil use might increase the risk of nasopharyngeal carcinoma incidence by 2.58-fold. Conclusion: There is an association between mosquito coils use with nasopharyngeal carcinoma.

Correlation of IgA-EA Epstein Barr Virus with Risk Factors on Nasopharyngeal Carcinoma Type III Roni Januardi; Yussy Afriani Dewi; Tonny Basriyadi
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 03 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i03.4507

Introduction: Nasopharyngeal carcinoma (NPC) is a tumor derived from epithelial cells on the surface of the nasopharynx. The etiology of NPC is multifactorial, including genetic, environmental, and virological factors. Approximately 90% of NPC patients have a positive serology of EBV against IgA EA. Increased IgA EA titre was associated with NPC incidence. Objective: To examine the relationship of the increased value of IgA EA EBV titre on NPC type III with risk factor of mosquito coil smoke, smoking, salted fish and preserved food. Methods: This study was prospective observational analytic in the clinic of Oncology Head and Neck Surgery, Hasan Sadikin Hospital Bandung period July-October 2017, followed by 90 subjects who underwent history, histopathologic, and serology examination IgA EA by ELISA method. Statistical analysis using Mann Whitney test and Exact Fisher correlation test. Results: Based on serology IgA-EA with ELISA in NPC type III patient, the level of IgA-EA titres on subjects of salted fish and preserved foods 1.52 to 5.24, smoking 1.22 to 2.53, and mosquito coil smoke was found in the level of IgA EA 1.13 to 2.12. Statistical analysis of quantitative IgA EA in NPC type III with the risk factor of salted fish and preserved foods had the highest mean value (2.10 ± 0.692). Conclusion: There is correlation of the increase of IgA-EA EBV titration on NPC type III with risk factors of salted fish and preserved foods, smoking, and the use of mosquito coils smoke. There is no correlation risk factors of NPC type III with clinical stage.

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