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All Journal JKM (Jurnal Kebidanan Malahayati) Jurnal SAGO Gizi dan Kesehatan
Maharani Maharani
Jurusan Kebidanan Poltekkes Kemenkes Aceh
Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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PENGARUH FLAVONOID EKSTRAK MAHKOTA DEWA (PHALERIA MACROCARPA) TERHADAP PENINGKATAN INDEKS APOPTOSIS PADA PERITONEAL MENCIT MODEL ENDOMETRIOSIS Maharani Maharani; Sutrisno Sutrisno
JKM (Jurnal Kebidanan Malahayati) Vol 7, No 4 (2021): Vol.7 No.4 Oktober 2021
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v7i4.4606

Abstract

Background: Endometriosis is one of the main reproductive problems today because the incidence is quite high. The development and progression of endometriosis cells results from an abnormal balance between cell proliferation and apoptosis. Cell apoptosis is triggered by an imbalance between positive signals (cell growth factors) and negative signals (DNA damage) in endometriosis. The anti-cancer effect of Mahkota Dewa has been shown to suppress cancer growth and inhibit cancer cell invasion through inhibition of proliferation and anti-apoptotic activity, Purpose: This study aimed to determine the effect of giving flavonoid extract from Mahkota Dewa fruit on the apoptotic index in endometriosis model mice. Methods: This research is an experimental study conducted at the Laboratory of the Faculty of Veterinary Medicine, Airlangga University, Surabaya. The sample used mice (Mus musculus) endometriosis model. The study was divided into 6 groups: negative control, positive control and treatment with the flavonoid extract of the Mahkota Dewa fruit at a dose of 3.75 mg/day, 7.5 mg/day, 11.25 mg/day and 15 mg/day. Measurement of apoptotic index using Tunel kit immunohistochemistry. Observational data were analyzed by ANOVA dan Tukey. Results: There was significant difference in the mean apoptotic index of the five groups of observational samples, the mean value of the apoptotic index was found between the KP group (7.96 ± 1.02) and the group given flavonoid extract from the Mahkota Dewa fruit group P1 at a dose of 3.75 mg (5.36 ± 0.91), P2 dose 7.5 mg (3.4 ± 0.49), P3 dose 11.25 mg (3.88 ± 0.59), P4 dose 15 mg (3.96 ± 0.75). Conclusion: The administration of flavonoid extract of the Mahkota Dewa fruit had a significant effect on increasing cell apoptotic index in endometriosis model mice.Suggestion Further study is needed to see the effect of flavonoid extract of Mahkota Dewa on rabbit experimental animals. Keywords: endometriosis, flavonoid extract of Mahkota Dewa fruit, apoptotic index ABSTRAK Latar Belakang: Endometriosis menjadi salah satu masalah reproduksi utama saat ini karena angka kejadian cukup tinggi. Perkembangan dan progresi sel endometriosis akibat terjadinya abnormalitas keseimbangan antara proliferasi dan apoptosis sel. Apoptosis sel dipicu karena adanya ketidakseimbangan antara sinyal positif (faktor pertumbuhan sel) dan sinyal negatif (kerusakan DNA) pada kondisi endometriosis. Efek anti kanker mahkota dewa terbukti dapat menekan pertumbuhan kanker dan menghambat terjadinya invasi sel kanker melalui penghambatan aktivitas proliferasi dan anti apoptosis.Tujuan: Penelitian ini bertujuan untuk mengetahui efek pemberian flavonoid ekstrak dari buah mahkota dewa terhadap indeks apoptosis pada mencit model endometriosis.Metode: Penelitian ini merupakan penelitian eksperimental yang dilakukan di Laboratorium Fakultas Kedokteran Hewan Universitas Airlangga Surabaya. Sampel menggunakan mencit (Mus musculus) model endometriosis. Penelitian dibagi menjadi 6 kelompok, yaitu : kontrol negatif, kontrol positif dan perlakuan pemberian ekstrak flavonoid buah mahkota dewa dosis 3,75 mg/hari, 7,5 mg/hari, 11,25 mg/hari dan15 mg/hari. Pengukuran indeks apoptosis menggunakan imunohistokimia Tunel kit. Data hasil pengamatan dianalisis dengan uji ANOVA dan Tukey. Uji statistik dikatakan bermakna bila p<0,05.Proses penghitungan dilakukan dengan bantuan piranti lunak (soft-ware) SPSS for windows 19.0.Hasil: Terdapat perbedaan yang bermakna rerata indeks apoptosis kelima kelompok sampel pengamatan didapatkan nilai rerata indeks apoptosis antara kelompok K- (7.96 ± 1.02) dengan kelompok pemberian ekstrak flavonoid dari buah mahkota dewa kelompok P1 dosis 3,75 mg (5.36 ± 0.91), P2 dosis 7,5 mg (3.4 ± 0.49), P3 dosis 11,25 mg (3.88 ± 0.59), P4 dosis 15 mg (3.96 ± 0.75).Kesimpulan: Pemberian ekstrak flavonoid buah mahkota dewa memberikan pengaruh yang signifikan terhadap peningkatan indeks apoptosis sel pada mencit model endometriosis.Saran Perlu studi lanjut untuk melihat pengaruh flavonoid ekstrak mahkota dewa pada hewan coba kelinci. Kata Kunci: endometriosis, flavonoid ekstrak buah mahkota dewa, indeks apoptosis
The Analysis Of Factors Related To The Prevalence Of Chronic Energy Deficiency (Ced) In Pregnant Women Maya Yunita; Yulia Fitri; Maharani Maharani
JKM (Jurnal Kebidanan Malahayati) Vol 9, No 1 (2023): Volume 9 No.1 Januari 2023
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v9i1.8965

Abstract

Latar Belakang: Angka kematian ibu Indonesia Tahun 2018 menunjukkan bahwa AKI adalah sebesar 305 kematian ibu per 100.000 kelahiran hidup. Ibu meninggal akibat komplikasi yang terjadi dari buruknya status gizi ibu dan pada akhirnya berdampak kepada kondisi kesehatannya begitu juga dengan kondisi janin yang dilahirkan. Prevalensi KEK wanita hamil usia subur (15-49 tahun) di indonesia adalah sebesar 17.3%.Tujuan Penelitian: Untuk melakukan review pada beberapa literature terkait faktor-faktor yang berhubungan dengan Kejadian Kekurangan Energi Kronik (KEK) pada Ibu Hamil.Metode Penelitian: Penelitian ini menggunakan metode literature review. Artikel dikumpulkan dengan melakukan penelusuran/ pencarian jurnal menggunakan Google Search atau bibliografi dari artikel yang ditelusur dan google scholarly. Literature review ini menggunakan literature terbitan tahun 2016-2019 yang dapat diakses fulltext dalam format pdf.Hasil literature review: Hasil penelitian menunjukkan bahwa Ada hubungan yang signifikan antara umur, ada hubungan pendapatan keluarga, ada hubungan pengetahuan, ada hubungan pendidikan, dan ada hubungan paritas dengan kejadian KEK pada ibu hamil.Kesimpulan dan Saran: Penelitian diatas menunjukkan adanya hubungan antara umur, pendapatan keluarga, pengetahuan, pendidikan, dan ada hubungan paritas dengan kejadian KEK pada ibu hamil.Saran diharapkan kepada lahan penelitian, penelitian ini dapat menjadi bahan masukan dalam mengambil kebijakan dalam mengatasi kejadian kekurangan energi kronik (KEK) pada ibu hamil. Kata kunci: Ibu hamil KEK, Umur, Pendapatan Keluarga, Pengetahuan, Pendidikan, Paritas. ABSTRACT Background: Indonesia's maternal mortality rate in 2018 shows that the MMR is 305 maternal deaths per 100,000 live births. The high maternal mortality rate is due to complications that occur from the poor nutritional status of the woman and ultimately impact her health condition as well as the condition of the fetus being born. The prevalence of pregnant women with CED of childbearing age (15-49 years) in Indonesia is 17.3%.Objectives: To review some literature related to factors associated with the prevalence of Chronic Energy Deficiency (CED) in Pregnant Women.Research Methods: This study uses the literature review method. Articles are collected by conducting a journal search using Google Search or a bibliography of the articles searched with Google Scholar. This literature review uses literature published in 2016-2019, which can be accessed in full-text in pdf format.Results: The results of the study show that there is a significant relationship between age, family income, knowledge, education, and parity with the incidence of CED in pregnant women.Conclusions: The above research shows a relationship between age, family income, knowledge, and education, and there is a relationship between parity and the incidence of CED in pregnant women.Suggestion The research field is expected to be used as input for policymaking in overcoming the incidence of chronic energy deficiency (CED) in pregnant women. Keywords: Chronic Energy Deficiency (CED); Pregnant women; Factors related to CED 
Literature review: Peran bidan terhadap keberhasilan pemberian ASI Eksklusif Maharani Maharani; Rizzatul Khumairoh
Jurnal SAGO Gizi dan Kesehatan Vol 4, No 2 (2023): Juni
Publisher : Politeknik Kesehatan Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v4i2.1106

Abstract

Background: exclusive breastfeeding in Aceh in 2021 (66.66%) has increased compared to 2020 (65.43%), but there has not been a significant increase. Efforts are needed to increase exclusive breastfeeding. Exclusive breastfeeding is one way of good growth and development. In addition, midwives play an important role in the success of exclusive breastfeeding. Midwives are responsible for exclusive breastfeeding education and care for breastfeeding mothers during pregnancy, starting from the first breastfeeding to breastfeeding mothers. Midwife support can also give mothers the confidence to continue giving exclusive breastfeeding to their babies.Objectives: to review several journals about the role of midwives in the success of exclusive breastfeeding.Methods: this research is a descriptive analysis. This research in literature review held ini may-june 2021. The keywords used are the role of the midwife and exclusive breastfeeding. Literature sources were obtained from the Google Scholar, Science Direct, and Pubmed publication databases with the last five years limitation A total of 224 articles were obtained with these keywords, then were selected in stages according to predetermined criteria. Retrieved 10 articles published in 2015-2020. The articles obtained were compiled, analyzed, and concluded by looking for similarities, dissimilarities, giving views, comparing and summarizing.Results: literature studies show that there is a relationship between the role of the midwife and the success of exclusive breastfeeding. Providing education, information and assessment about exclusive breastfeeding is the responsibility of midwives to mothers starting from the period of pregnancy, the beginning of breastfeeding until the baby is 6 months old.Conclusion: the midwife has a role in the success of exclusive breastfeeding 
Co-Authors maya yunita Rizzatul Khumairoh Sutrisno Sutrisno Yulia Fitri