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Syntia Nusanti
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology Physics Public Health

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Diagnosis and Management of Devic’s Disease Desrina Desrina; Syntia Nusanti; M. Sidik
Majalah Oftalmologi Indonesia Vol 41 No 3 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (406.267 KB) | DOI: 10.35749/journal.v41i3.38

Abstract

Background: To report diagnosis and management of Devic’s Disease with good visual outcome.Case Illustration: A 51 years-old male came with sudden blurred vision of his right eye since 3 days.The patient also complained of lower limbs weakness, urinary retention, and defecation disorder.Ophthalmology examination revealed visual acuity of no light perception in the right eye and 6/12 inthe left eye. Light reflex of both eyes decreased. Funduscopy examination of the right eye showed anindistinct edge and hyperemic optic nerve head, cup-disc ratio was hard to be evaluated, artery/vein ratioof  2/3, macular reflex was positive and the retina was good. Funduscopy of the left eye was within normallimit. No pathological finding in brain Magnetic Resonance Imaging (MRI). Thoracolumbal MRI supportlongitudinal transverse myelitis. The patient was diagnosed as Devic’s Disease and treated initiallywithintravenous methylprednisolone 1 g/day for five days followed by methyl prednisolone orally.Conclusion: Early diagnosis of Devic’s Disease is important because immediate therapeutic interventionis required to get excellent result, prevent relapse and further disability.
Methanol Toxic Optic Neuropathy (Characteristic and Evaluation of Therapy) Ardiella Yunard; Syntia Nusanti; M. Sidik
Majalah Oftalmologi Indonesia Vol 42 No 1 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i1.62

Abstract

Background: Methanol toxic optic neuropathy is and optic neuropathy caused by methanolintoxication. Management of methanol toxic optic neuropathy is a therapeutic challenge and theoutcome is often unsatisfying. The aim of this study is to know the characteristics and evaluate theoutcome of corticosteroid therapy in methanol toxic optic neuropathy.Methods: Medical records of patients diagnosed with methanol toxic optic neuropathy from January2013 to December 2014 were reviewed retrospectively. Demographic characteristic, clinicalcharacteristic and visual acuity were evaluated.Results: During the period of January 2013 until December 2014, 31 patients were diagnosed withmethanol toxic optic neuropathy. All of them were males. The mean age was 31.87±9.23 years. Ocularsymptoms were found in 93.5%, most of them occured in 24-96 hours after methanol consumption.There were 85.4% patients at initial presentation had visual acuity (VA) less than 3 m finger counting,and 72.6% showed optic disc edema. Among the patients, 42% got intravenous high-dosemethylprednisolone, 19% got combination of intravenous high-dose methylprednisolone andhemodyalisis, 26% got oral methylprednisolone, and 3% got neuroprotector. VA improvement aftertherapy occured in 67.7%, no changes in 26.47%, and worsening in 5.88%. All patients who gottherapy in 6 days after methanol consumption showed VA improvement.Conclusion: The administration of intravenous high-dose steroids showed an improvement of visualstatus in most of the patients. Intravenous high-dose steroids gave benefit the visual status of patientswith methanol optic neuropathy, especially in patients with short interval between the consumption ofmethanol and starting the treatment. Keywords: methanol intoxication, optic neuropathy, methylprednisolone
Diagnosis and Management of Devic’s Disease Desrina Desrina; Syntia Nusanti; M. Sidik
Majalah Oftalmologi Indonesia Vol 41 No 3 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v41i3.38

Abstract

Background: To report diagnosis and management of Devic’s Disease with good visual outcome.Case Illustration: A 51 years-old male came with sudden blurred vision of his right eye since 3 days.The patient also complained of lower limbs weakness, urinary retention, and defecation disorder.Ophthalmology examination revealed visual acuity of no light perception in the right eye and 6/12 inthe left eye. Light reflex of both eyes decreased. Funduscopy examination of the right eye showed anindistinct edge and hyperemic optic nerve head, cup-disc ratio was hard to be evaluated, artery/vein ratioof  2/3, macular reflex was positive and the retina was good. Funduscopy of the left eye was within normallimit. No pathological finding in brain Magnetic Resonance Imaging (MRI). Thoracolumbal MRI supportlongitudinal transverse myelitis. The patient was diagnosed as Devic’s Disease and treated initiallywithintravenous methylprednisolone 1 g/day for five days followed by methyl prednisolone orally.Conclusion: Early diagnosis of Devic’s Disease is important because immediate therapeutic interventionis required to get excellent result, prevent relapse and further disability.
Methanol Toxic Optic Neuropathy (Characteristic and Evaluation of Therapy) Ardiella Yunard; Syntia Nusanti; M. Sidik
Majalah Oftalmologi Indonesia Vol 42 No 1 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i1.62

Abstract

Background: Methanol toxic optic neuropathy is and optic neuropathy caused by methanolintoxication. Management of methanol toxic optic neuropathy is a therapeutic challenge and theoutcome is often unsatisfying. The aim of this study is to know the characteristics and evaluate theoutcome of corticosteroid therapy in methanol toxic optic neuropathy.Methods: Medical records of patients diagnosed with methanol toxic optic neuropathy from January2013 to December 2014 were reviewed retrospectively. Demographic characteristic, clinicalcharacteristic and visual acuity were evaluated.Results: During the period of January 2013 until December 2014, 31 patients were diagnosed withmethanol toxic optic neuropathy. All of them were males. The mean age was 31.87±9.23 years. Ocularsymptoms were found in 93.5%, most of them occured in 24-96 hours after methanol consumption.There were 85.4% patients at initial presentation had visual acuity (VA) less than 3 m finger counting,and 72.6% showed optic disc edema. Among the patients, 42% got intravenous high-dosemethylprednisolone, 19% got combination of intravenous high-dose methylprednisolone andhemodyalisis, 26% got oral methylprednisolone, and 3% got neuroprotector. VA improvement aftertherapy occured in 67.7%, no changes in 26.47%, and worsening in 5.88%. All patients who gottherapy in 6 days after methanol consumption showed VA improvement.Conclusion: The administration of intravenous high-dose steroids showed an improvement of visualstatus in most of the patients. Intravenous high-dose steroids gave benefit the visual status of patientswith methanol optic neuropathy, especially in patients with short interval between the consumption ofmethanol and starting the treatment. Keywords: methanol intoxication, optic neuropathy, methylprednisolone
Co-Authors Ardiella Yunard Desrina Desrina M. Sidik