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All Journal Jurnal Pengabdian Masyarakat (ABDIRA) Proceeding of Mulawarman Pharmaceuticals Conferences
Nur Shidiq
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Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Social Sciences Other

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Sintesis Senyawa Turunan Flavanon dan Uji Bioaktivitas Senyawa Kalkon sebagai Senyawa Antara dalam Sintesis Flavanon Nur Shidiq; Agung Rahmadani; Viriyanata Wijaya; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.743 KB) | DOI: 10.25026/mpc.v8i1.305

Abstract

Golongan metabolit sekunder yang memiliki aktivitas biologi sepeti antikanker, antitumor, antiproliferatif, dan antimikroba adalah golongan flavonoid dimana flavanon merupakan salah satu senyawanya. Dalam penelitian ini senyawa 2-hidroksi-5-kloro asetofenon dan 4-hidroksi benzaldehida direaksikan melalui reaksi Kondensasi Claisen-Schmidt menghasilkan senyawa turunan kalkon yaitu 2’-hidroksi-5’-kloro-4-hidroksikalkon. Kemudian senyawa 6-kloro-4’-hidroksi flavanon disintesis melalui reaksi siklisasi turunan kalkon dengan metode refluks menggunakan asam sulfat di dalam etanol sebagai katalis. Senyawa hasil sintesis dikarakterisasi dengan teknik elusidasi struktur menggunakan 1H-NMR, 13C-NMR dan MS (Mass Spectroscopy). Dilakukan uji aktivitas antioksidan dan uji toksisitas dari senyawa 2’-hidroksi-5’-kloro-4-hidroksi kalkon hasil sintesis dengan menggunakan metode DPPH dan metode BSLT (Brine Shrimp Lethality Test) dan dihitung nilai IC50 dan LC50 dengan menggunakan analisis Reed and Muench. Nilai IC50 dan LC50 senyawa 2’-hidroksi-5’-kloro-4-hidroksi kalkon diperoleh 131,19 ppm dan 46,465 ppm
Usaha Lulur Daun Pepaya untuk Menghadapi Pandemi Covid-19 Riski Sulistiarini; Novita Eka Kartab Putri; Fathul Jannah; Nur Shidiq; Kasdi Kasdi; Yuni Fardalianna; Gayuk Kalih Prasesti
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 2, No 4 (2022): Abdira, Oktober
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v2i4.203

Abstract

The purpose of this community service activity is as a form to improve the community's economy during the COVID-19 pandemic by utilizing waste from papaya leaves. With this training in making scrubs, it is hoped that it can increase creativity and public awareness of the potential for waste around to be used as business opportunities, especially during this COVID-19 pandemic. Currently commercially available cosmetic formulations (exfoliants) for topical use are alpha hydroxy acids, beta hydroxy acids and retinoids, which can cause adverse reactions. Therefore, it is necessary to use cosmetic ingredients consisting of effective and non-irritating exfoliants, one of which is the use of papaya leaves which are formulated as scrubs. The target of this activity is the residents of Mugirejo Village, Samarinda, East Kalimantan. Education and training on making scrubs went smoothly and without any problems. All residents followed the training process carefully and were very enthusiastic, as evidenced by the full attention of the residents until the end of the activity. Through representatives of community leaders, this activity is considered very useful and is expected to increase the potential for utilizing papaya leaf waste which can be used as a business opportunity.
Co-Authors Agung Rahmadani Fathul Jannah Gayuk Kalih Prasesti Kasdi Kasdi Laode Rijai Novita Eka Kartab Putri Sulistiarini, Riski Viriyanata Wijaya Yuni Fardalianna