Garuda - Garba Rujukan Digital

Mukti Priastomo

Laboratorium Penelitian dan Pengembangan Kefarmasian ?Farmaka Tropis? Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295748

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Pengaruh Pemberian Kombinasi Jus Buah Naga (Hylocereus polyrhizus) dan Air Rebusan Daun Kersen (Muntingia calabura) pada Penderita DM (Tipe 2): Effect of Combination of Dragon Fruit (Hylocereus polyrhizus) Juice and Kersen Leaf (Muntingia calabura) Boiled Water in DM (Type 2) Patients Aprilia Putri Firdaus; Mukti Priastomo; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes mellitus is a disease characterized by an increase in blood glucose levels, which prevalence in East Kalimantan in 2018 is the third highest in Indonesia. Kersen leaves and dragon fruit are believed to regulate blood glucose levels in people with type 2 diabetes mellitus and can be used as a complementary therapy. This study aims to see the characteristics, determine the organoleptic assessment of the combination of dragon fruit juice with kersen leaves boiled water and its effect on blood glucose levels, blood pressure, heart rate, body weight, and the frequency of polyuria, polyphagia, and polydipsia in patients type 2 diabetes mellitus at Klinik Semoga Sehat Samarinda. The research method used was quasi experimental with pre-test and post-test procedures. The data obtained from the characteristics were 70% aged 50-59 years, 70% women, 50% diploma/bachelor, 60% housewives. For organoleptic assessment, it was found that 70% liked the taste, texture, aroma and color and 50% did not feel bitter. The combination of dragon fruit with kersen leaves boiled water had an effect on reducing blood glucose levels significantly (P 0.05) and there was a change in the frequency of polyuria, polyphagia, polydipsia by 80% did not urinate frequently and were not often thirsty and 90% were less hungry.

Penambatan Molekuler Senyawa Metabolit Sekunder Bawang Dayak (Eleutherine bulbosa) Sebagai Penghambat Dipeptidil Peptidase IV (DPP-4): Molecular Binding of Secondary Metabolite Compounds of Dayak Onion (Eleutherine bulbosa) As Dipeptidyl Peptidase IV (DPP-4) Inhibitors Nur Ainah; Mukti Priastomo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes is a frightening disease that threatens people's lives, because almost every 10 seconds in the world, people die from complications of this disease. A new DM treatment approach in the creatinase system that inhibits dipeptidyl peptidase IV (Dpp-4) has been developed, and has been shown to effectively increase insulin secretion, maintain pancreatic -integration, and slow gastric emptying. antidiabetic, namely inhibition of the -glucosidase enzyme in one of its compounds and has not been found to inhibit the Dpp-4 enzyme. This study aims to determine the potential of the compounds in Dayak onions as inhibitors of the Dpp-4 enzyme. The method used is molecular anchoring or in silico because the research time is short and the cost is cheaper than in vitro or in vivo. The software used is autodock which is a device that can attach ligand molecules to receptor macromolecules. Then visualized using discovery studio 2020 and other devices to support tethering such as chemdraw and chimera 1.4. vidagliptin as an antidiabetic which has activity against inhibiting Dpp-4 inhibitors was used as a standard. The grid is placed on natural ligands with a box size of 52? x 28? x 26? and a center of 40,926? x 50,522? x 35,031? with a spacing of 0.375?. Based on the docking that has been done, the secondary metabolite compounds in Dayak onions have a low bond energy value, with the lowest value being -8.46 kcal/mol and the highest -5.54 with different values of inhibition constant and bond form. Eleuthoside C has the lowest bond energy of -8.46 and has the most similar interaction with natural ligands. The bond that occurs is the type of hydrogen bonding at the residues of Phe357, Arg125, Arg358, Tyr666, Tyr662, and Glu205. With this, Dayak onions have antidiabetic activity but further docking still needs to be done to see other compounds in Dayak onions as Dpp-4 inhibitors.

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