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Fajar Novianto

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Author-ID : 4338548

Medicine & Pharmacology

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STUDI KLINIK EFEK SEDUHAN FORMULA JAMU HIPERTENSI TERHADAP FUNGSI GINJAL Agus Triyono; Fajar Novianto
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Clinical study on the effect of hypertension herbs steeping formula on the renal functions has been done. Hypertension herb formula consists of Apium graveolens L.; Orthosiphon spicatus (Thunb.); Centella asiatica (L.); Curcuma xantoriza; Phyllantus niruri, and Curcuma domestica. Clinical trials were conducted by open-label clinical trial and pre-post test design. Thirty human subjects who have met the inclusion and exclusion criteria were involved in this study. The study protocol was approved by the research ethics of Ethics Committee for Health Research, National Institute of Health Research and Development, Ministry of Health. Before the treatment, the subjects who had signed informed consent performed anamnesis, medical history, clinical symptoms, physical examination and laboratory tests of renal function (BUN and creatinine levels). The subjects treat with the hypertension herbs steeping formula three times a day for eight weeks, then controlled it once a week. Anamnesis on the clinical symptoms, the possibility of side effects and physical examination diagnostic on the subject performed every week. Measurement on the renal function performed every four week. Base on the anamnesis and physical examination, the clinical study concluded that there were no significant adverse effects on the subject. Paired t-test results showed that there was no significant difference on subject’s BUN and creatinine levels before and after the treatment hypertension herbs steeping formula on the 28th and 56th day (p <0.05). Clinically, the treatment of hypertension herb steeping formula for 56 days did not affect the subject’s renal function. Key words: Hypertension herbs steeping formula, renal function

STUDI KLINIS FORMULA JAMU ANTIHIPERGLIKEMIA TERHADAP FUNGSI HATI Fajar Novianto; Agus Triyono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Salam leaf (Syzygium polyanthum), sambiloto (Andrographis paniculata), kayu manis (Cinnamomum burmani), and temulawak (Curcuma xanthoriza) is one of the jamu formulas are potentially developing as antihyperglycemic jamu in diabetes mellitus therapy. One of the important indicators of jamu formula safety is its toxicity on the liver function. The purpose of this study is to evaluate the safety of jamu formulas for hyperglycemic against liver function. This study is a clinical trial with a quasi-experimental design pre and post test design. The research conducted in jamu scientification clinic Hortus Medicus Tawangmangu on 45 healthy volunteers. The jamu formula is decoction of salam leaf (5 g), sambiloto (5 g), kayu manis (7 g), and temulawak (10 g). Jamu drinks three times a day. Forty-five healthy volunteers divided into three groups (each group consists of 15 healthy volunteers). Healthy volunteers (in group 1, II, and III) consuming jamu for 5, 10, and 15 days. Levels of SGOT and SGPT research subject reviewed before and after treatment. The difference in levels of SGOT and SGPT before and after treatment analyzed statistically with the paired t-test. The results showed there is no significance difference obtained at levels of SGOT and SGOT of healthy volunteers before and after jamu treatment on day 5, 10 and 15 (p > 0.05). This research concluded the antihyperglycemic jamu formula consisting of salam leaves (5 g), sambiloto (5 g), kayu manis (7 g), and temulawak (10 g) does not cause any signs of toxicity in the liver function. Key words: Clinical trial, hyperglycemia jamu formula, liver function

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