Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Ria Rositasati
Unknown Affiliation
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
PENGEMBANGAN MODEL HEWAN PERCOBAAN TIKUS DIABETES MELLITUS TIPE 2 KARENA RESISTENSI INSULIN YANG DIINDUKSI DENGAN HUMAN INSULIN JANGKA PANJANG Yance Anas; Ria Rositasati; Meita Rafika Fitriani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.535 KB) | DOI: 10.31942/jiffk.v12i2.1408

Abstract

ABSTRACT Hyperinsulinemia may precede insulin resistance in patients with Type 2 diabetes.  In this study, we tried to reveal an influence of long-term treatment of human  insulin to hyperglycemic and insulin resistance in male Wistar rats.  Before the experiment, blood-glucose  levels measured two hours after 2 g/Kg glucose imposition.  Rats receive human insulin (0.45-1.80) IU/KgBW/day subcutaneously every day for 14 days.   Furthermore, human insulin 1.8 IU/KgBW/day also provide a period of7,14and 21days. At theend of the experiment,we mademeasurements ofblood-glucoselevelstwo hoursafterthe imposition  glucose.There are, the influence oflong-termtreatment of human insulin determined bycomparing the blood-glucoselevelsbeforeandafter  insulin treatment.  Insulin resistance isdeterminedby comparing thehypoglycemiceffect of glibenclamide 10 mg/Kg  BW  to the control group.  The results concluded that the  humaninsulin1.80 IU/KgBW/day  treatment  for 14dayscan improveblood-glucoselevel'sWistarmale ratsup to126.369mg/dL(p<0.05)withpatternsdoes notdepend onthe length of timeof administration.The averageof % hypoglycemiceffect of glibenclamide10mg/kgBW  in ratswhoreceived treatment with human  insulin 1.80IU/kg BW/dayswereat 18,31%,smaller thancontrols (62.20%) (p<0.05). Decrease in hypoglycemic effects of glibenclamide 10 mg/kg BW caused by mice has insulin resistance might be due to a result of long-term insulin administration. Keywords : Human insulin, insulin resistance, Type 2 diabetes animal models
Co-Authors Meita Rafika Fitriani Suharjono, Suharjono Yance Anas