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riyanta aribawa

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Author-ID : 4338690

Medicine & Pharmacology

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DAYA ANTELMINTIK EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) TERHADAP CACING Ascaridia galli SECARA In Vitro DAN PROFIL KLTNYA riyanta aribawa; anis wihdayanti; mustofa mustofa
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeople used noni leaf (Morinda citrifolia L.)for medication many kinds disease, one of as anthelmintic. Worm infection most generally in the world, especially in growing countries including indonesia. To prove the truth were efficacious noni leaf as anthelmintic has been research anthelmintic capability ethanol extract of noni leaf on the worm Ascaridia galli on in vitro. This research has done by using Lamson and Brown method submerges that has been modified. Research using 270 of worms A. galli female, that devided into 9 groups, that’s 4 groups treatment with ethanol extract of noni leaf in consentration of 20 mg/mL, 30 mg/mL, 40 mg/mL and 50 mg/mL, 4 groups positive control (citrate piperazin) consentration 2 mg/mL, 4 mg/mL, 6 mg/mL dan 8mg/mL and I group negative control (NaCl 9 mg/mL) each group consist of 6 petri disc (each petri disc contain 5 of worms and 25 ml solution). Anthelmintic capability showed with worm mortality time that’s observed every 2 hours and LC50 that needed consentration to wipe out 50% of worm. The result of this research shown rates worm mortality time after submerges with ethanol extract of noni leaf consentration 20 mg/mL, 30 mg/mL, 40 mg/mL and 50 mg/mL as hight as 48,00 ± 1,79 ; 44,33 ± 1,51; 40,33 ± 1,51; 36,00 ± 2,53 (hours). But after submerges with citrate piperazin 4 mg/mL is 34,33 ± 1,51 (hours). LC50 after submerges ethanol axtract of noni leaf is 50,21 mg/mL and after submerges 2,27 mg/mL. The result of the observed Thin Layer Chromatography (TLC) shown ethanol extract of noni leaf containes compounds from flavonoid and fenol. Based on result of the reseach would be concluded that ethanol extract of noni leaf contain compounds that calculate have anthelmintic activity, possibilty that’s compounds is flavonoid and fenol. Keyword : Morinda citifolia L. , anthelmintic, submerges of Lamson and Brown.

DAYA ANTELMINTIK EKSTRAK ETANOL BIJI SRIKAYA (Annona squamosa L.) TERHADAP CACING Ascaridia galli SECARA In Vitro DAN PROFIL KLTNYA riyanta aribawa; atiq fauziyah; mustofa mustofa
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTCustard apple (Annona squamosa L.) is one of efficacious medical plant that often used by local community for constipation, insectiside, carbuncle, scabies, gastrointestinal problem such diarrhoea, dysentery and anthelmintic. In Indonesia, worm disease is infection disease that still high prevalention. Although modern anthelmintic is in stock, but still common community is to use medical plant, specialy custard apple for therapeutic worm disease. The aim of this research was to deterinate anthelmintic capability of ethanol extract of seed custard apple on the worm Ascaridia galli on in vitro. This researches were pure experimental by using Lamson and Brown method submerges that have been modified by using 270 of worm femele, that devided into 9 groups treatment, which was 4 groups for ethanol extract of seed custerd apple in concentration of 10 mg/mL, 20 mg/mL, 30 mg/mL, 40 mg/mL, 4 positive control groups (citrate piperazinae 2 mg/mL, 4 mg/mL, 6 mg/mL, 8 mg/mL) and negative control group (NaCl 9 mg/mL). Each group consist of 6 petri disc and each petri disc contain 5 of worm and 25 mL solution. Anthelmintic capability is measurement observed is the mortality time rate of the worm and value LC50, that is concentration is needed for killing 50% worm population and than analysed date by one way ANOVA and continued by Least Significant Difference (LSD) test. The research result, shown that mortality time rate of worm after submerges by ethanol extract of seed custrad apple in concentration 10 mg/mL, 20 mg/mL, 30 mg/mL, and. 40 mg/mL is 43,33; 38,00; 37,66 and 34,33 hours. Exactly after submerges by citrate piperazinae 4 mg/mL shown mortality time rate of worm is 34,33 hour. LC50 value of ethanol extract of seed custard apple and piperazinae citrate at 12th hour is 36,94 mg/mL and 2,26 mg/mL. Result Thin Layer Chromatography (TLC) shown seed custard apple containes compounds such as from alkaloid, flavonoid and tanin. That compounds is posibility efficacious anthelmintic. Keywords : Annona squamosa L., anthelmintic, Lamson and Brown method submerges.

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