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Ariani

Department of Child Health, Faculty of Medicine, Universitas Brawijaya, Saiful Anwar General Hospital, Malang, Indonesia

Author-ID : 4379715

Health Professions Public Health

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Articles

The effect of centella asiatica extract in Zebrafish (Danio rerio) larvae as a Chronic Constant Hypoxia (CCH) model Ariani; Teni Widiyastuti
Pediatric Sciences Journal Vol. 1 No. 1 (2020): (Available online 1 June 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Backgound: Chronic Constan Hypoxia (CCH) are able to occur in cyanotic congenital heart disease and bronchopulmonary dysplasia (BPD). Centella asiatica has antioxidant and neuroprotective effects in experimental animals.This study aims to observe the effect of Centella asiatica ethanol extract on Zebrafish in chronic hypoxic conditions Method: A laboratory experimental study with a randomized post-test controlled group design was conducted among 20 Zebrafish (Danio rerio) 3-8 day post fertilization (dpf) as samples per tube. The total group treatment was five with inclusion and exclusion criterias. Variables assessed in this study included Average body length, locomotor activity, and the relationship between average body length and locomotor activity. Data were analyzed using SPSS version 18 for Windows. Result: There was a moderate significant correlation between Centella asiatica concentration of 1.25 µg/ml, 2.5 µg/ml, 5 µg/ml with an enhancement of body length (r=0.431) and locomotor activity (r=0.262) in zebrafish larvae CCH model (p<0.05). Conclusion: It can be concluded that chronic constan hypoxia (CCH) inhibit the growth of body length and decrease locomotor activity in Zebrafish larvae. Centella asiatica treatment can avoid the CCH by using various concentration.

Cytogenetic and clinical features of down syndrome in malang, east java, indonesia Ariani
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: Down syndrome (DS) is the most common chromosomal disorder. DS characterized by multiple congenital anomaly caused by trisomy 21This study was designed to evaluate the karyotype pattern, clinical features and risk factors of patients with Down syndrome. Method: Data were obtained from a retrospective analysis of a questionnaire from Down syndrome patients. Result: A total of 34 patients were studied, with 67,6% of males. Out of 34 patients, there were 25 children (73,5%) with no cytogenetic test, 4 children (11,7%) with lost cytogenetic test, 3 children (8,82%) with free trisomy (non-disjunction), 1 (2,9%) with translocation, and 1 (2,9%) with mosaics. Maternal age categories showed one mother less than 20 years, two mothers between 21-25 years, four mothers were between 25 and 30 years, 12 mothers were between 31 and 35 years, ten mothers were between 31 and 40 years, and five mothers were over 41 years of age. The most common clinical features in this study are Congenital Heart Disease (CHD), which was recognized in 9 (26,4%) patients with five patients had Atrial Septal Defect (ASD), two patients had ASD and Ventricular Septal Defect (VSD), two patients had Patent Ductus Arteriosus (PDA). All of them followed by dental problems in 8 (23,5%) patients, ophthalmology problems in 6 (17,6%) patients, digestive problems in 4 (11,7%) patients, seizure in 1 (2,9%) patient, hormonal problems in 1 (2,9%) patient, and hearing problem in 1 (2,9%) patient. There is no significant difference in CHD prevalence between each maternal age group (p = 0776, p>0.05). Conclusion: Down syndrome has a higher prevalence in males and is frequently seen among mothers between 31 -35 years of age, yet maternal age did not seem to influence CHD prevalence significantly. Early diagnosis and proper screening should be undertaken among these patients.

Post-Traumatic Stress Disorder Following Surgery: A Case Report of A Three-Year-Old Child with Deep Dermal Burn Injury Hajeng Wulandari; Ariani
Pediatric Sciences Journal Vol. 1 No. 2 (2020): (Available online 1 December 2020)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Introduction: In the past few years, there has been increased recognition that children, who have a history of traumatic incidences, can develop post-traumatic stress disorder (PTSD), just like in adults. Case: We presented a case of PTSD in a 3-year-old child hospitalized in the hospital for two days due to combustion (deep dermal burn injury) in his left hand, stomach, and both of his legs. The patient started to experience parasomnia such as nightmares, raves, difficulty to sleep and awakened from sleep (for one month from the beginning of wound treatment and debridement). The patient also had two re-experiencing symptoms: nightmare and emotional distress (anxiety, anger) after a traumatic stimulus. From his temperament scale and character assessment, there was dysregulation disorder. From the PEDSQL parent's reports, there was also decreased quality of life. Conclusion: First-line therapy of PTSD for the pediatric population is supportive psychotherapy with trauma-focused cognitive behavioral therapy (TF-CBT) that results in a remarkable improvement in child's psychiatric outcome.

Pericardial effusion in status epilepticus and global developmental delay one-year-old patient with co-exist of atrial septal defect: a case report Pradhika Perdana Sakti; Ariani
Pediatric Sciences Journal Vol. 3 No. 2 (2022): Available online : 1 December 2022
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i2.33

Introduction: Atrial septal defect (ASD) is one of the most common types of congenital heart disease (CHD) and occurs due to spectrum closure failure during the intrauterine period. ASD is generally asymptomatic, but it can affect patients from various aspects. Case presentation: A 1-year-old 4-month-old girl was referred with a major complaint of shortness of breath as early as 6 days before hospital admission. The dullness accompanied by a fever disappears, as convulsions, pallor and vomiting. On physical examination, a positive result in pathological reflex was found in a decrease in consciousness, epicantal fold, conjunctiva and pale skin, and edema of the left limb. The patient was examined for echocardiography and found the presence of moderate primum ASD with a left to the right pyre, mild tricuspid regurgitation with the possibility of pulmonary hypertension, and effusion pericardium with the collapse of the right atrium. In the laboratory results show the presence of normochromic normocytic anemia, leukocytosis, mild hyponatremia, hypokalemia, hypocalcemia, hypophosphatemia, increased PCT, increased SGOT / SGPT, PT elongation, a decreased of free T4 and increase in TSH, IgG CMV (+), IgG toxoplasma (+), IgG HSV-1 (+), IgG HSV-2 (+), and IgG Rubella (+). The patient is given treated at the PICU and provided with the help of ventilation, antibiotics, antipyretics, anticonvulsants, inotropic, and sympathomimetic agents. On the ninth day of care, the patient experienced cardiac arrest. RJP was performed, but the patient did not have ROSC and was pronounced dead. Conclusion: ASD affects the patient's condition as well as the patient's survival both directly and indirectly. There is a link between ASD and developmental disorders, pericardial effusion and patient mortality. It is necessary to conduct a comprehensive evaluation and management of patients with ASD.

Co-Authors Hajeng Wulandari Pradhika Perdana Sakti Teni Widiyastuti

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