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All Journal JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Essential: Essence of Scientific Medical Journal
Vincentius Mario Yusuf
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Potensi Injeksi Intra-artikular Sel Punca Mesenkimal sebagai Terapi Osteoartritis Lutut: Vincentius Mario Yusuf; Ivena Leonita; Aurielle Annalicia Setiawan; Muhammad Yusuf
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 9 No 2 (2021): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 9.2 Edisi Agustus - No
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v9i2.483

Abstract

Background: Osteoarthritis (OA) is a chronic multifactorial disease (inflammatory, mechanical, and metabolic) that is most often found in knee joints. Current OA therapy mostly uses NSAIDs as symptomatic treatment, with severe side-effects in long-term use. Therefore, a new causative therapy is needed that can minimize side effects and also has high efficacy. Mesenchymal stem cells (MSC) have promising potential for further research as a novel therapy for OA. Methods: This systematic review was conducted by including validated studies extracted from PubMed, Cochrane, ScienceDirect, dan ProQuest databases, using the keywords “knee osteoarthritis” and “mesenchymal stem cells” with a publication range of 2011-2021. RCT studies examining the use of intra-articular injection of MSC for knee OA were included. Outcome measures used were Visual Analog Scale (VAS), Western Ontario and McMaster University Osteoarthritis Index (WOMAC), MRI results (WORMS, cartilage volume, cartilage defect size), and side effects. Discussion: MSC can improve clinical assessment of OA, as seen from the significantly improved WOMAC and VAS scores and also radiological improvement, as seen from the improved WORMS scores, cartilage defects and volume. MSCs have anti-inflammatory and immunomodulatory potential, and are able to stimulate cartilage-like cells, which can assist in the recovery and prevention of further development of OA. Adverse effects are generally mild and self-limiting, therefore safe for human use. Conclusion: Intra-articular injection of MSC is potentially effective as a method of knee OA therapy with minimal side effects.
POTENSI FOTODINAMIK SEBAGAI MODALITAS TERAPI ALTERNATIF NON INVASIF PADA ORAL CANCER Timotius William Yusuf; Jason Chen; Vincentius Mario Yusuf
Essence of Scientific Medical Journal Vol 20 No 1 (2022): Volume 20 No. 1 (Januari - Juli 2022) Essential: Essence of Scientific Medical J
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2022.v20.i01.p04

Abstract

Introduction: Oral cancer is defined as a type of malignancy that occurs in the oral cavity and occupies the top 10 leading causes of cancer worldwide. Oral cancer mortality rate is high with a five-year survival rate of only 50-60%. The current treatment is invasive, risky, with severe complications that can reduce therapy efficacy and patients’ quality of life. Based on previous studies, photodynamics is a promising alternative therapy for oral cancer because of its selective non-invasive traits and good clinical results. Methods: This literature review was done based on PICO and determined inclusion criterias. Studies were extracted from “PubMed”, “ScienceDirect”, and “SpringerLink” databases using “boolean operator” search method. Results & Discussion: There were a total of 11 clinical studies that met the inclusion criteria and stated that photodynamic therapy was effective in the treatment of oral cancer. Clinical efficacy is seen from high complete response rates and survival rates accompanied by low recurrence rates. The mechanism underlying its efficacy is photosensitizer excitation triggers the production of reactive oxygen species that lead to the destruction of cancer cells. It was also found that photodynamic exposure can cause shut-down of tumor tissue blood vessels and activation of immune system. The most common side effects are pain, swelling, and photosensitivity. In general, side effects found are not fatal, can be controlled and do not cause lasting functional or aesthetic impacts. Conclusion: Photodynamic is effective as a non-invasive therapy modality in oral cancer with good clinical efficacy and safety profile.
Co-Authors Aurielle Annalicia Setiawan Ivena Leonita Jason Chen MUHAMMAD YUSUF Timotius William Yusuf