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All Journal The Journal of Pure and Applied Chemistry Research Jurnal Kimia Mulawarman Jurnal Wiyata : Penelitian Sains dan Kesehatan JURNAL ATOMIK Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical Education
Riska Yudhistia Asworo
Poltekkes Kemenkes Malang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Education

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Pengaruh Ukuran Serbuk Simplisia dan Waktu Maserasi terhadap Aktivitas Antioksidan Ekstrak Kulit Sirsak Riska Yudhistia Asworo; Hanandayu Widwiastuti
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19906

Abstract

Secondary metabolites are one of the active substances in natural materials that are known to contain high antioxidants and are very beneficial for health. In addition to mangosteen, there are also natural ingredients that actually have high antioxidant content, but many people do not know about it, one of which is soursop fruit. In addition to the fruit, the skin of soursop fruit may contain antioxidants that are quite high. The purpose of this study was to determine the effect of different maceration times and powder sizes on the antioxidant activity of secondary metabolite compounds produced from ethanol-aquades extract of soursop fruit peel (Annona muricata L.). This study was conducted quantitatively with a descriptive research design where researchers conducted laboratory research conducted in triplo. This research used particle size variation of 50 mesh, 100 mesh, and 200 mesh and maceration time variation of 24 hours, 30 hours, 36 hours. From this study it can be seen that the difference in powder size and maceration time affects the results of antioxidant activity obtained. The optimum particle variation is using 200 mesh size, which is obtained antioxidant activity of 95.2%. While the optimum maceration time is for 24 hours, the yield is 94%. From this study it can also be seen that the ethanol-aquades extract of soursop fruit peel contains secondary metabolite compounds of triterpenoids, saponins, polyphenols and tannins.
Sintesis Nanopartikel Perak menggunakan Ekstrak Kulit Sirsak sebagai Bioreduktor Riska Yudhistia Asworo; Hanandayu Widwiastuti; Elok Widayanti
Indonesian Journal of Pharmaceutical Education Vol 3, No 3 (2023): September-Desember 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i3.22310

Abstract

Soursop peel can be used as a bioreductor in the green synthesis process of silver nanoparticle formation. This is because the content of secondary metabolite compounds in soursop peel can reduce Ag3+ to Ag0 in nano size. Secondary metabolites in soursop peel are obtained by extraction using a solvent whose polarity value is close to the polarity value of soursop peel secondary metabolites. In this study, ethanol-aquadest and ethanol solvents were used. The extract obtained was then formulated with AgNO3 solution with a concentration variation of 0.5; 1; 1.5 and 2 mM to determine the optimum concentration on the formation of silver nanoparticles. The maximum concentration was obtained at a concentration of 2 mM AgNO3, seen from the highest absorbance obtained at the maximum wavelength observation of 400-450 nm with the concentration of AgNO3 used 2 mM. The silver nanoparticles formed were then analysed using a Particle Size Analyzer (PSA) to determine the size of the nanoparticles formed. Nanoparticles using ethanol-aquadest solvent had a size of 92.83 nm, while those using ethanol solvent had a size of 301.3 nm.
Co-Authors Abdullah Arief Agatha Abriyanti Dewi Akhmad Sabarudin Elok Widayanti Elok Widayanti Hanandayu Widwiastuti Hanandayu Widwiastuti Hanandayu Widwiastuti Jauhar Fatin Muna Niken Cahyaning Wulandari Niken Cahyaning Wulandari Rachmat Triandi Tjahjanto Yustina Suhandini Tjahjaningsih