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Hendrata Erry Andisari
Fakultas Kedokteran Universitas Hang Tuah
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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KEGAWATAN PADA REAKSI TRANSFUSI Hendrata Erry Andisari
Denta Journal Kedokteran Gigi Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2
Publisher : Universitas Hang Tuah

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Abstract

Reaksi tranfusi dapat dibedakan antara yang dimediasi imun dan tidak dimediasi imun. Keduanya dapat terjadi segera maupun reaksinya bisa lambat. Reaksi tranfusi yang dimediasi imun biasanya terjadi akibat aloantibodi setelah terekspose dengan antigen asing seperti kehamilan, tranfusi atau transplantasi. Kontaminan leukosit dapat menyebabkan aloimmunisasi, transmisi dari penyakit menular, TRALI dan imunomodulasi. Dengan pelatihan yang tepat untuk mengenali tanda dan gejala reaksi transfusi, komplikasi yang muncul akibat transfusi dapat dihindari. Diketahuinya penyebab sebagian besar reaksi transfusi bersifat klerikal sehingga dilakukan usaha untuk mencegah kesalahan klerikal sepanjang proses transfusi. Eksklusi kontaminan leukosit dari darah dan produk darah dapat mengurangi insiden FNHTR, aloimunisasi, dan imunosupresi. Filtrasi darah dan produk darah sebelum penyimpanan dapat menjadi cara yang efektif untuk mengatasi masalah tersebut terkait kontaminasi leukosit. Jika protokol transfusi yang tepat serta prosedur operasional standar diikuti, maka insiden reaksi transfusi dapat sangat menurun.
Recent Therapeutics Policies of Arthritis Rheumatoid (part I) Hendrata Erry Andisari
Denta Journal Kedokteran Gigi Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018
Publisher : Universitas Hang Tuah

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Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional diseasemodifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.
PERKEMBANGAN TERKINI TERAPI RHEUMATOID ARTHRITIS (bagian 2) Hendrata Erry Andisari
Denta Journal Kedokteran Gigi Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional disease-modifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.
Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Thalia Tamara; Hendrata Erry Andisari; Totot Mudjiono
Denta Journal Kedokteran Gigi Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

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Abstract

Background: Rheumatoid Arthritis (RA) is an autoimmune disease with an increasingprevalence from year to year. RA mortality continues to increase in the last 1 decade due tothe absence of effective prevention and therapy. Hyperbaric oxygen therapy can be anadjuvant therapy for Rheumathoid Arthritis.Objective: This study uses Hyperbaric Oxygen Therapy to reduce the inflammatory reactionin patients with Rheumatoid Arthritis.Method: Samples used are 16 male balb/c mice, divided into 2 groups, 1) group of inducedexperimental animals as models of Rheumatoid Arthritis 2) group of induced experimentalanimals as models of Rheumatoid Arthritis and given 3x30 minutes of 2.4 ATA hyperbaricoxygen therapy for 10 consecutive days. On 59th day, ELISA screening test is performed forC-ReactiveProtein measurement.Result: The average results of C-Reactive Protein levels between 2 groups, are, the group ofmice with rheumatoid arthritis model that was not treated with HBO therapy had an averageCRP level of 0.204 Pg / ml, while the group of mice with rheumatoid arthritis model which istreated with HBO therapy has a mean CRP level of 0.113 Pg / ml.Conclusion: There is an effect of hyperbaric oxygen therapy to C-Reactive Protein level inmice with rheumatoid arthritis model.
Seorang Penderita SLE dengan Emboli Paru Akut dan Hipertensi Pulmonal (Studi Kasus) Hendrata Erry Andisari; Gede Kambayana; Ketut Suega
Denta Journal Kedokteran Gigi Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

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Abstract

Kondisi Pulmonary embolism (PE) merupakan bagian dari spektrum penyakit yang disebut Venous thromboembolism (VTE). Seorang pasien dengan keluhan utama batuk yang mengeluarkan dahak berwarna keputihan datang ke RSUP Sanglah, Bali untuk mendapatkan terapi. Riwayat sebelumnya, pasien pernah dirawat inap di RSUP Sanglah tersebut.Saat ini diagnosis akhir pasien ini: SLE on treatment dengan moderate pulmonary hipertension dan suspek emboli paru, suspek pneumonia (HCAP) dengan severe sepsis dan syok sepsis, asidosis metabolik, observasi transaminitis ec reaktif dan hiponatremia kronik asimptomatik hipoosmoler euvolemic cb SIADH. Selanjutnya dilakukan tindakan terapi dan evaluasi terhadap terapi yang diberikan.
KEGAWATAN PADA REAKSI TRANSFUSI Hendrata Erry Andisari
Oceana Biomedicina Journal Vol 4 No 2 (2021): Oceana Biomedicina Journal Volume 4 Issue (No) 2
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v4i2.15

Abstract

Reaksi tranfusi dapat dibedakan antara yang dimediasi imun dan tidak dimediasi imun. Keduanya dapat terjadi segera maupun reaksinya bisa lambat. Reaksi tranfusi yang dimediasi imun biasanya terjadi akibat aloantibodi setelah terekspose dengan antigen asing seperti kehamilan, tranfusi atau transplantasi. Kontaminan leukosit dapat menyebabkan aloimmunisasi, transmisi dari penyakit menular, TRALI dan imunomodulasi. Dengan pelatihan yang tepat untuk mengenali tanda dan gejala reaksi transfusi, komplikasi yang muncul akibat transfusi dapat dihindari. Diketahuinya penyebab sebagian besar reaksi transfusi bersifat klerikal sehingga dilakukan usaha untuk mencegah kesalahan klerikal sepanjang proses transfusi. Eksklusi kontaminan leukosit dari darah dan produk darah dapat mengurangi insiden FNHTR, aloimunisasi, dan imunosupresi. Filtrasi darah dan produk darah sebelum penyimpanan dapat menjadi cara yang efektif untuk mengatasi masalah tersebut terkait kontaminasi leukosit. Jika protokol transfusi yang tepat serta prosedur operasional standar diikuti, maka insiden reaksi transfusi dapat sangat menurun.
Recent Therapeutics Policies of Arthritis Rheumatoid (part I) Hendrata Erry Andisari
Oceana Biomedicina Journal Vol 1 No 1 (2018): Oceana Biomedicina Journal Vol 1 Issue (No) 1 January-June 2018
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i1.2

Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional diseasemodifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.
PERKEMBANGAN TERKINI TERAPI RHEUMATOID ARTHRITIS (bagian 2) Hendrata Erry Andisari
Oceana Biomedicina Journal Vol 1 No 2 (2018): Oceana Biomedicina Journal Volume 1 Issue (No) 2 July - December 2018
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v1i2.14

Abstract

Therapy in RA has undergone many advances today and in line with knowledge of the pathogenesis of RA, the current therapeutic goal is to alter the journey and control the activity of RA disease. Several groups of drugs have been used in RA therapy including non-steroidal anti-inflammatory drugs (NSAIDs), conventional disease-modifying antirheumatic drugs (DMARDs) as well as biological agents (bDMARD), glucocorticoids and anti-pain medicines. In recent years, the development of biological agents that have specific targets for inflammatory mediators such as interleukin (IL) -1, IL-6 and Tumor Necrosis Factor (TNF) suggests a potent therapeutic effect on RA. In this article will be presented the latest biological agents as the latest therapy on RA.
Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Thalia Tamara; Hendrata Erry Andisari; Totot Mudjiono
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.33

Abstract

Background: Rheumatoid Arthritis (RA) is an autoimmune disease with an increasingprevalence from year to year. RA mortality continues to increase in the last 1 decade due tothe absence of effective prevention and therapy. Hyperbaric oxygen therapy can be anadjuvant therapy for Rheumathoid Arthritis.Objective: This study uses Hyperbaric Oxygen Therapy to reduce the inflammatory reactionin patients with Rheumatoid Arthritis.Method: Samples used are 16 male balb/c mice, divided into 2 groups, 1) group of inducedexperimental animals as models of Rheumatoid Arthritis 2) group of induced experimentalanimals as models of Rheumatoid Arthritis and given 3x30 minutes of 2.4 ATA hyperbaricoxygen therapy for 10 consecutive days. On 59th day, ELISA screening test is performed forC-ReactiveProtein measurement.Result: The average results of C-Reactive Protein levels between 2 groups, are, the group ofmice with rheumatoid arthritis model that was not treated with HBO therapy had an averageCRP level of 0.204 Pg / ml, while the group of mice with rheumatoid arthritis model which istreated with HBO therapy has a mean CRP level of 0.113 Pg / ml.Conclusion: There is an effect of hyperbaric oxygen therapy to C-Reactive Protein level inmice with rheumatoid arthritis model.
Seorang Penderita SLE dengan Emboli Paru Akut dan Hipertensi Pulmonal (Studi Kasus) Hendrata Erry Andisari; Gede Kambayana; Ketut Suega
Oceana Biomedicina Journal Vol 3 No 1 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 1 January - June 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i1.31

Abstract

Kondisi Pulmonary embolism (PE) merupakan bagian dari spektrum penyakit yang disebut Venous thromboembolism (VTE). Seorang pasien dengan keluhan utama batuk yang mengeluarkan dahak berwarna keputihan datang ke RSUP Sanglah, Bali untuk mendapatkan terapi. Riwayat sebelumnya, pasien pernah dirawat inap di RSUP Sanglah tersebut.Saat ini diagnosis akhir pasien ini: SLE on treatment dengan moderate pulmonary hipertension dan suspek emboli paru, suspek pneumonia (HCAP) dengan severe sepsis dan syok sepsis, asidosis metabolik, observasi transaminitis ec reaktif dan hiponatremia kronik asimptomatik hipoosmoler euvolemic cb SIADH. Selanjutnya dilakukan tindakan terapi dan evaluasi terhadap terapi yang diberikan.
Co-Authors Gede Kambayana Ketut Suega Thalia Tamara Totot Mudjiono