Article Per Year (5 Year)
p-Index From 2019 - 2024
0
P-Index
This Author published in this journals
All Journal Program Kreativitas Mahasiswa - Penelitian
Meirizky Zulharini S
Fakultas Farmasi Universitas Gadjah Mada

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
MAHKOTA DEWA (PHALERIA MACROCARPA) SEBAGAI ANTINEFROTOKSISITAS “DEWA PENYELAMAT” DALAM PENURUNAN EFEK SAMPING CISPLATIN Zulharini S, Meirizky; L.R, Annishfia; Hidayah, Siti Nurul; Iman, Naisbitt
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (605.678 KB)

Abstract

Cisplatin is one of the most widely used chemotherapeutic agent in cancer treatment, however it possess series of harmful adverse effects, most notably, nephrotoxicity. Due to that reason, a natural chemopreventive agent is needed to minimize cisplatin’s toxicity, namely, Mahkota Dewa fruit (Phaleria marcocarpa) extract. This research aim to determine anti nephrotoxic effect of mahkota dewa fruit on Vero cells, model of renal cells. Cytotoxic assay of mahkota dewa’s extract and cisplatin both single and combination was determined using MTT assay on HeLa cells and Vero cells. The cytotoxic assay resulted that IC50 value of cisplatin and Mahkota Dewa to HeLa cells were 18µM (5,4 µg/mL) and 845 µg/mL, respectively, whereas the IC50 value of cisplatin and Mahkota Dewa to Vero were 80 µM (24 µg/mL) and 730 µg/mL, respectively. The results indicated that cisplatin was more cytotoxic to HeLa cell in comparison to Vero cell. Combination treatment of mahkota dewa’s extract at 183 µg/mL and cisplatin 284 µM showed increased viability of Vero cells. Therefore, combination treatment of cisplatin and mahkota dewa are able to decrease nephrotoxicity of cisplatin to renal cells.  Keyword: Mahkota dewa, cisplatin, flavonoid, nephrotoxicity, HeLa cell, Vero cell
Co-Authors Annishfia L.R Naisbitt Iman Siti Nurul Hidayah