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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Journal of Educational, Health and Community Psychology Althea Medical Journal The Indonesian Biomedical Journal
Veronika Maria Sidharta
Department Of Histology, School Of Medicine And Health Sciences, Atma Jaya Catholic University Of Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Body Mass Index, a Body Shape Index, and Waist-to-Height Ratio in Predicting Elevated Blood Pressure Bryan Junius Winata; Veronika Maria Sidharta; Linawati Hananta; Vetinly Vetinly; Nawanto Agung Prastowo
Althea Medical Journal Vol 9, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v9n1.2291

Abstract

Background: One of the complications of obesity is an elevation in blood pressure  which can increase the risk of hypertension. This study aimed to explore body mass index (BMI), a body shape index (ABSI), and waist-to-height ratio (WHtR) in predicting elevated blood pressure (BP).Methods: This study was conducted in a cross-sectional design on 215 medical students from October 2019 to September 2020. Respondents measured their own weight, height, waist circumference and BP. Receiver operating characteristics (ROC) curve were analyzed using IBM SPSS v.23. Results: Of the 215 medical students who participated in this study, only 102 met the inclusion criteria. The majority of the students were female (n=71, 69.6%) with a mean age of 19.37 years, and normal blood pressure (n=90, 88.2%). Area under the ROC curve (AUC) of WHtR and ABSI were 0.774 (p-value= 0.002) and 0.766 (p-value= 0.003) respectively, which were still acceptable. However, the AUC of BMI (p-value=0.589) was 0.11, which was considered poor.Conclusion: The indicators of obesity can be used as a screening value for increased blood pressure in adults, with BMI being the weakest indicator compared to ABSI and WHtR. Further research is needed to examine ABSI and WHtR indicators as predictor of increased blood pressure in adults.
Sedentary Screen Time as a Coping Strategy of Distance Learning-induced Distress during COVID-19 Pandemic Ghea Mangkuliguna; Mahaputra Mahaputra; Veronika Maria Sidharta; Linawati Hananta
Journal of Educational, Health and Community Psychology Vol 10 No 2 June 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jehcp.v10i2.19969

Abstract

During the COVID-19 pandemic, medical students might be vulnerable to excessive screen time exposure to cope with distance learning-induced distress. This study aimed to evaluate the distress and screen time before and after distance learning was initiated. Data were collected from 215 subjects. Statistical significance was accepted at P<0.05. The prevalence of distress among medical students was 25.61% and 27.06% before and after distance learning was executed, respectively. Academic-related stressor (ARS) was reported by 49.28% and 63.29% of students during the first and second surveys. The proportion of students with daily screen time ≥7 hours was 51.21% and 63.77% for the first and second surveys, respectively. ARS, interpersonal and intrapersonal-related stressor (IRS), social-related stressor (SRS), and average daily screen time significantly rose in 3-month-time (P<0.0001, P=0.0014, P=0.0261, P=0.0022). There was a significant association between distress and screen time (P=0.0313). ARS was the leading cause of distress. The majority of respondents had a daily screen time ≥7 hours. Both distress and screen time levels significantly increased as distance learning kept progressing.Keywords: COVID-19; distance learning; mental distress; medical students;                        screen time.
High VEGF Level is Produced by Human Umbilical Cord- Mesenchymal Stem Cells (hUC-MSCs) in Amino Acid-Rich Medium and under Hypoxia Condition Veronika Maria Sidharta; Elizabeth Henny Herningtyas; Christine Ayu Lagonda; Dilafitria Fauza; Yuyus Kusnadi; Rina Susilowati; Ginus Partadiredja
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.457

Abstract

BACKGROUND: Secretome production by stem cells depends on their culture conditions such as oxygen concentration and the composition of the culture media. In this study, we investigated the secretion of neurotrophic growth factors of human umbilical cord mesenchymal stem cells (hUC-MSCs) in amino acid-rich culture medium and under hypoxic condition.METHODS: hUC-MSCs were cultured in normoxic and various hypoxic (1%, 5%, 10%) conditions in an amino acid-rich culture medium. The end-point parameters (cell proliferation and survival, cell morphology and growth factor secretion) were measured at 3 time-points (48 hours, 72 hours and 96 hours). ELISA-based methods were used for neurotrophic factors detection, including neurotrophic growth factor (NGF), vascular endothelial factor (VEGF), and brain-derived neurotrophic factor (BDNF).RESULTS: NGF secretion was not detectable at any time points both in normoxia and hypoxia. BDNF secretion under normoxia was induced at 48 h time point and reached the highest level at an average of 181.9±13.01 pg/mL at 96 hours, whereas hypoxia exposure to hUC-MSCs only induced the BDNF secretion at low level. VEGF secretion was barely detectable in normoxic condition. However, VEGF secretion reached the highest level at an average of 7707.55±2110.85 pg/mL in 5% hypoxia at 96 hours.CONCLUSION: Combination of amino acid-rich culture medium and hypoxia condition dramatically induced high VEGF secretion by hUC-MSCs, especially at 5% hypoxia, induced mild BDNF secretion and had no effect toward NGF secretion.KEYWORDS: human umbilical cord mesenchymal stem cells, neurotrophic growth factor, amino acid-rich, hypoxia
Skin manifestations in patients with covid-19: A literature review Gunawan, Danny; Stella, Maureen Miracle; Sidharta, Veronika Maria
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1237.235 KB) | DOI: 10.30659/sainsmed.v13i1.15563

Abstract

Coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. In December 2019, cases of pneumonia with unknown cause were first reported in Wuhan, Hubei Province, China. Confirmed cases and death rates due to COVID-19 in the world are still increasing. One part of the body that is affected and causes clinical symptoms in COVID-19 is the skin. This review aims to describe and analyze cutaneous manifestation in COVID-19. This study method is a review of the literature sourced from Google Scholar and PubMed. The literature was selected using English language criteria, using the clinical study method in the form of case reports. Meanwhile, literature review, systematic literature, and meta-analysis were excluded. Journal searches were carried out using the keywords "skin" OR "cutaneous" AND "manifestation" AND "COVID-19" OR "coronavirus". The skin manifestations of COVID-19 have been observed. The most common clinical symptoms of COVID-19 were fever (47%), dry or productive cough (25%), sore throat (16%), generalized sore throat (6%), and pain (5%). However, currently there has been a shift in the approach to diagnosing COVID-19 because it can cause symptoms in other organ systems, one of which is skin manifestations. There are early reports of skin involvement (erythematous rash, extensive urticaria, and chickenpox-like vesicles) occurring in 20% of patients in the course of the COVID-19 disease. In addition, several case reports provide descriptions of petechiae and chilblains. Based on the cases that have been reported, patients with COVID-19 who have manifestations on the skin can give a picture of maculopapular eruptions, vesicular eruptions, petechiae, and also childblains.
Co-Authors Bryan Junius Winata Christine Ayu Lagonda Dilafitria Fauza Elizabeth Henny Herningtyas Ghea Mangkuliguna Ginus Partadiredja Gunawan, Danny Hananta, Linawati Mahaputra Mahaputra Nawanto Agung Prastowo Rina Susilowati Stella, Maureen Miracle Vetinly Vetinly Yuyus Kusnadi