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All Journal Althea Medical Journal
Januarsih A. Rachman, Januarsih A.
epartment of Anatomy and Cell Biology Faculty of Medicine Universitas Padjadjaran
Medicine & Pharmacology

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The Protective Effect of Field Mint Leaves in Reducing Stomach Ulcer in Rats Induced by Aspirin Krisnan, Vanitha Ratha; Rachman, Januarsih A.; Hassan, Abdul Hadi
Althea Medical Journal Vol 2, No 3 (2015)
Publisher : Althea Medical Journal

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Abstract

Background: Stomach mucosal wall erosion is caused by the imbalance of the aggressive factors and mucosal defensive factors due to the common causes such as the side effect of consuming non-steroidal anti-inflammatory drugs. Field mint (Menthaarvensis) leaves have been used as an alternative option to cure and prevent the gastric problems. The aim of this study was to analyze the protective effect of Field mint leaves infusion in reducing stomach ulcer in rats induced by Aspirin.Methods: The experimental study was conducted at Histology Laboratory of Faculty of Medicine, Universitas Padjadjaran, Bandung. Sixteen rats were divided into 4 groups randomly: group I (control negative group), group II (control positive group, given 90mg/day Aspirin, group III (the treatment group, given 5cc of Field mint leaves infusion and 90 mg Aspirin) and group IV (the treatment group, given 5.6µg of Misoprostol and 90 mg Aspirin). Mucosal wall erosions were determined by using microscope. Data were analyzed using non-parametric Kruskal-Wallis test and Mann-Whitney U-test (CI 95% and p-value<0.05)Results: Group II had high score of mucosal wall erosions after given only aspirin. In group III and IV, the score of mucosal wall erosions were low. However there was no difference in score of mucosal wall erosions between group III-IV (p<0.05)Conclusions: Field mint (Menthaarvensis) leaves infusion is able to prevent stomach mucosal wall erosions induced by Aspirin as misoprostol does. DOI: 10.15850/amj.v2n3.496
Effect of Centella asiatica Leaves on Gastric Ulcer in Rats Mariska, Ester; Sitorus, Trully D.; Rachman, Januarsih A.
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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  Background: Gastric ulcer is disruption of gastric mucosal integrity due to lack of smaller defensive factors (e.g. mucus levels) than gastric aggressive factors. Centella asiatica is a traditional medicine that contains triterpenoids and flavonoids. The objective of this study was to analyze the effect of ethanol extract of Centell aasiatica leaves for preventing gastric mucus level reduction of aspirin-induced gastric ulcer model in rats and compared it to misoprostol.Methods: An experimental laboratory study using 24 rats that were divided into 4 groups. Group I (negative control) received carboxymethy cellulose (CMC) solution, group II (positive control) received CMC and aspirin 450mg/kg, group III (tested group) received Centella asiatica 400 mg/kg and aspirin 450 mg/kg, group IV (compared group) received misoprostol 72μg/kg and aspirin 450mg/kg for three days. Then the rats were laparatomied and their gastric mucus levels were measured. The results were statistically analyzed by Independent T-test.Results: The mean levels of gastric mucus of group I, II, III, IV, respectively were 0.112; 0.035; 0.537; 0.455 optical densities per gram of tissue. The statistical test suggested a significant difference between the positive control group and tested group. Moreover there is no significant difference between the tested group and compared group.Conclusions: Centella asiatica leaves can prevent gastric mucus level reduction of aspirin-induced gastric ulcer model in rats and has similar effect in gastric mucus level with misoprostol.Keywords: Centella asiatica, gastric mucus, gastric ulcer, misoprostolDOI: 10.15850/amj.v2n1.444 
Co-Authors Abdul Hadi Hassan, Abdul Hadi Ester Mariska, Ester Trully D. Sitorus Vanitha Ratha Krisnan, Vanitha Ratha