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All Journal Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Kedokteran Komunitas (Journal of Community Medicine)
Nugroho Wibisono
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health

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STUDI PUSTAKA SISTEMATIS: DELIMA MEMPERBAIKI KADAR NITRIC OXIDE PADA BERBAGAI KONDISI STRES OKSIDATIF Siti Norazizah; Nugroho Wibisono; Doti Wahyuningsih
Jurnal Kedokteran Komunitas Vol 9, No 1 (2021)
Publisher : Jurnal Kedokteran Komunitas (Journal of Community Medicine)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (632.966 KB)

Abstract

Abstrak : Nitric Oxide (NO) merupakan suatu radikal bebas. Peningkatan kadar NO didapatkan pada berbagai kondisi stres oksidatif. Pemberian ekstrak delima dilaporkan dapat memperbaiki kadar NO dalam kondisi stres oksidatif karena adanya kandungan antioksidan pada delima terutama senyawa polifenol. Penelitian menggunakan metode studi pustaka sistematis bertujuan mengetahui pengaruh delima (Punica granatum) terhadap kadar Nitric Oxide (NO) pada serum, plasma, jaringan hepar, otak, limfe, usus, ginjal dan endotel yang diperoleh dari penyakit yang patofisiologinya melibatkan stres oksidatif (injury, toksisitas, inflamasi dan infeksi). Bagian delima yang dipelajari pada penelitian ini adalah buah, kulit, biji dan bunga. Studi pustaka sistematis. Pengumpulan data penelitian dilakukan melalui sumber PubMed, dan Google Scholar dengan kata kunci Punica granatum, Antioxidant, dan Nitric Oxide. Melalui proses screening didapatkan data berupa 14 artikel memenuhi kriteria inklusi yang telah ditetapkan. Senyawa antioksidan yang terdapat dalam ekstrak buah, kulit, bunga, dan biji delima terbukti mampu memperbaiki nilai NO dengan menurunkan kadar NO pada jaringan hepar, otak, usus, limfe, ginjal dan meningkatkan NO pada jaringan endotel pada kondisi stres oksidatif. Melalui 14 jurnal yang ditelaah, mekanisme antioksidan utama ekstrak delima dalam memperbaiki nilai NO adalah melalui peningkatan antioksidan dan pembersihan radikal bebas. Pemberian ekstrak buah, biji, kulit, dan bunga delima (Punica granatum) dapat memperbaiki kadar radikal NO pada kondisi stres oksidatif.Kata Kunci : Punica granatum, Antioxidant, Nitric Oxide
Uji Aktivitas Antidiabetes Kulit Batang Pulai (Alstonia scholaris) melalui Studi In Silico dan Prediksi Profil Farmakokinetika Nugroho Wibisono; Yoyon Arif Martino
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 8 No 2 (2023): Januari 2023
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/e-jbst.v8i2.511

Abstract

Alstonia scholaris is a medicinal plant from the Apocynaceae family. Alstonia scholaris stem bark have some medicinal properties, but their effect on antidiabetics mechanisms is still unclear. Alstonia scholaris stem bark have some active compounds such as Echitamine, Beta Sitosterol, Lupeol, Alpha Amyrin Acetate, and Betulinic Acid. Present study was designed to find out the best active compounds of A. scholaris as a potential therapeutics agent against diabetes mellitus. This study involved the molecular docking of 3D structures of those active compounds into GLUT-1 receptor protein, visualized their result using Biovia Discovery Studio and pharmacokinetics profile prediction analysis using pkCSM web page. The molecular docking result show that Echitamine (-8,7 kcal/mol) have the lower energy compared to glibenclamide (-9,6 kcal/mol). Based on pkCSM web page, Echitamine were have a good pharmacokinetics profile.
Efek Pemberian Ekstrak Etanol Daun Jarak Merah (Jatropha gossypiifolia L.) terhadap Kadar Glukosa Darah Puasa, Kadar Insulin Serum dan HOMAIR pada Model Tikus DM Tipe 2 Nugroho Wibisono; Achmad Basori; Suhartati
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 11 No. 2 (2022): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v11i2.19225

Abstract

Abstract. Jatropha gossypiifolia L. is a medicinal plant from theEuphorbiaceae family. Jatropha gossypiifolia L. leaves have somemedicinal properties, but their effect on antidiabetics mechanisms isstill unclear. Jatropha gossypiifolia leaves have some activecompounds such as alkaloid, flavonoid, phenol, saponins, tannins,steroid, terpenoid, and triterpenoid. The presentstudy was designedto analyze effect of Jatropha gossypiifolia leaves extract activecompounds on fasting blood glucose levels, serum insulin levels andHOMA-IR. The design of thisresearch istrue experimental with posttest only control group design with independent variables includinga high-fat diet, streptozotocin injections, Jatropha gossypiifolia L.leaves extract in doses of 60, 120, dan 240 mg/kg and dependentvariables including fasting blood glucose levels, serum insulin levels,and HOMA-IR. Based on this study, there were a significantlydifferent between fasting blood glucose levels and HOMA-IR controlgroups than the extract groups. It can be concluded that Jatrophagossypiifolia L. leaves extract has effect on fasting blood glucoselevels, serum insulin levels and HOMA-IR on DM type 2 rat models.
Co-Authors Achmad Basori Doti Wahyuningsih Siti Norazizah Suhartati Yoyon Arif Martino