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All Journal Proceedings of the International Conference on Nursing and Health Sciences Media Farmasi Indonesia
Diyah Ayu Wulandari
Universitas Duta Bangsa Surakarta
Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Other

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Optimasi Formula Krim Ekstrak Etanol Daun Kelor (Moringa oleifera Lamk) Dengan Emulgator Span 80 Dan Tween 80 Diyah Ayu Wulandari; Muladi Putra Mahardika; Tatina Siska Wardani
Media Farmasi Indonesia Vol. 17 No. 1 (2022): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (601.127 KB) | DOI: 10.53359/mfi.v17i1.197

Abstract

Moringa plant (Moringa Oleifera Lamk) contains various free radical inhibitory molecules, such as phenolic compounds (phenolic acids, flavonoids, quinones, coumarins, lignans, stilbenes, tannins), nitrogen compounds (alkaloids, amines, betalains), vitamins, terpenoids (including carotenoids). ), and several other endogenous metabolites rich in antioxidant activity. When span 80 and tween 80 are mixed in a suitable composition and in their manufacture the aqueous phase is dispersed into the oil, span 80 and tween 80 will be arranged alternately at the interface of the oil phase and water phase forming a monolayer that surrounds the droplets so as to produce good emulsifying properties. and form a stable O/A type emulsion. In this study, concentration variations were carried out to see the optimum formula for the ethanol extract of Moringa leaf cream with a mixture of span 80 and tween 80 to see the best physical properties. The cream was made in 5 formulas with variations of span 80 and tween 80 using the Simplex Lattice Design method with the parameters of adhesion, dispersion, pH, viscosity, and protective power. Data that were normally distributed were followed by One Sample T-test, one sample with 95% confidence level. The optimum formula is found in a concentration ratio of span 80: tween 80 (0:1) with a desirability value obtained that is 0.986.
Optimization of Moringa Leaf (Moringa Oleifera Lamk) Ethanol Extract with Span 80 and Tween 80 Emulsifier Diyah Ayu Wulandari; Nurul Izzati Osman; Tatina Siska Wardani; Muladi Putra Mahardika
Proceedings of the International Conference on Nursing and Health Sciences Vol 3 No 1 (2022): January-June 2022
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v3i1.1152

Abstract

Moringa plant (Moringa Oleifera Lamk) contains various free radical inhibitory molecules, such as phenolic compounds (phenolic acids, flavonoids, quinones, coumarins, lignans, stilbenes, tannins), nitrogen compounds (alkaloids, amines, betalains), vitamins, terpenoids (including carotenoids) and several other endogenous metabolites rich in antioxidant activity. When span 80 and tween 80 are mixed in a suitable composition and in their manufacture the aqueous phase is dispersed into the oil, span 80 and tween 80 will be arranged alternately at the interface of the oil phase and water phase forming a monolayer that surrounds the droplets so as to produce good emulsifying properties. and form a stable O/A type emulsion. Determine the optimum concentration of span 80 and tween 80 in the formulation of ethanol extract cream of Moringa leaves (Moringa oleifera Lamk) by testing the physical properties and cream of the cream In this study, concentration variations of span 80 and tween 80 to see the best physical properties. The statistical analysis using the Simplex Lattice Design versi 11 method with the parameters of adhesion, dispersion, pH, viscosity, and protective power. The optimum formula is in formula 2 with a ratio of span 80: tween 80 is 0:1 which indicates a desirability value of 0.986. Conclusions. The optimum formula is formula 2 with a ratio of span 80 and tween 80 0:1, where the results of the stability test by cycling test have relatively better physical stability in terms of organoleptic, homogeneity, disperersion, adhesion, pH, viscosity.
Co-Authors Muladi Putra Mahardika Nurul Izzati Osman Tatina Siska Wardani