Geostatistics is a data processing in geological field that contains spatial information in it. Spatial information is information that identifies geographical location, characteristics of natural conditions and boundaries of the earth. Geostatistics is used to handle regionalized variables. One of the method that used to handle regionalized variables is the kriging method. The kriging method has a lot of expansion in its development, including the Simple Kriging method and the Cokriging method. Both of these methods will be applied in case studies of spatial patterns of dengue in Tanah Laut District. The purpose of this study was to estimate the distribution pattern of DHF in Tanah Laut District and compare the results of the RMSE method of Simple Kriging and Cokriging. The smallest RMSE value was compared and selected, followed by estimation using the Cokriging and Simple Kriging methods. From the two methods used the smallest RMSE value is in the Simple Kriging method. But when you looked from the thematic map of the distribution of dengue patients with the Cokriging and Simple Kriging method, it can be seen that the Cokriging method has a more diverse pattern. Keywords: geostatisticts , Cokriging , Simple Kriging , DHF